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Pulmonary infections in cystic fibrosis patients with focus on epidemiology, virulence genes, and immunology

Christina Welinder-Olsson

 

 

 

 

 

 

 

 

 

 

Contact Information | List of Publications

 

Cystic fibrosis (CF) is the most common human genetic disease and is caused by defect chloride channels in the epithelial cells which gives a viscous mucus in the lungs and in the gastrointestinal tract. Lung infections is the most important reason for a lower life expectancy in CF patients. Their lungs are often colonised and infected by for example Staphylococcus aureus, Haemophilus influenzae, Pseudomonas aeruginosa, Aspergillus fumigatus, Candida albicans and Exophiala dermatitidis. Development of more resistant strains of these bacteria and fungi is troublesome and in many cases the patient experiences lifelong colonisation by micro-organisms in spite of extensive antibiotic treatment. Chronic colonisation causes permanent inflammation and lung injuries. Lung transplantation has lengthened the lives of the patients.
In the project, S. aureus, P.aeruginosa, Mycobacterium abscessus and E. dermatitidis will be studied by new molecular-biological methods.
The immunological response among CF-patients to different microbes will be compared to age-matched controls to be able find contributing reasons to why some CF-patients are more often infected chronically by some bacterial species and fungi. The aim is to obtain better strategies for treatment and to diminish the amount of infections and mitigate the effect of these.

Contact information:

Christina Welinder Olsson,
Verksamhetschef Klinisk mikrobiologi
molekylärbiolog, Doc
Sahlgrenska Universitetssjukhuset
Besöksadress: Guldhedsgatan 10 A, 413 46 GÖTEBORG
Postadress: Box 7193, 402 34 Göteborg
Tel (dir) 031-342 46 88
e-post christina.welinder-olsson@vgregion.se
Tel (växel) 031-342 10 00

Christina Welinder-Olsson

Contact information

List of publications

Group members

Christina Welinder Olsson, Molecular biologist, PhD, group leader, Associate professor (University of Gothenburg), Head of Dept Clinical Microbiology Sahlgrenska University Hospital
Ewa Johansson, PhD, Molecular biologist at Sahlgrenska University Hospital
Bodil Jönsson, MD, PhD, consultant/senior physician at Sahlgrenska University Hospital
Nahid Kondori, PhD, Microbiologist, Head of unit, at Sahlgrenska University Hospital
Merna Oshalim, Biomedical Scientist at Sahlgrenska University Hospital
Anna Bergman, Biologist, at Sahlgrenska University Hospital.

Sidansvarig: Dan Baeckström|Sidan uppdaterades: 2015-11-09
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