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  • Mohammad Razavi; Nachiket P. Marathe; Michael R Gillings; Carl-Fredrik Flach; Erik Kristiansson; D. G. Joakim Larsson. (2017). Discovery of the fourth mobile sulfonamide resistance gene. Microbiome. Accepted.
  • Bengtsson-Palme J, Gunnarsson L, Larsson DGJ. (2018). Can branding and price of pharmaceuticals guide informed choices towards improved pollution control during manufacturing? J Clean Prod. 171:137. https://doi.org/10.1016/j.jclepro.2017.09.247
  • Jutkina J, Marathe NP, Flach C-F, Larsson DGJ. (2017). Antibiotics and common antibacterial biocides stimulate horizontal transfer of resistance at low concentrations. Sci Total Environ. 616-617:172. https://doi.org/10.1016/j.scitotenv.2017.10.312
  • Bengtsson-Palme J, Larsson DGJ. (2017). Protection goals must guide risk assessment for antibiotics. Environ int. In press. http://dx.doi.org/10.1016/j.envint.2017.10.019
  • Bengtsson-Palme J, Kristiansson E, Larsson DGJ. (2017). Environmental factors influencing the development and spread of antibiotic resistance. FEMS Micro Rev. Accepted. https://doi.org/10.1093/femsre/fux053
  • Berglund F, Nachiket MP, Österlund T, Bengtsson-Palme J, Kotsakis S, Flach CF, Larsson DGJ, Kristiansson E. (2017). Identification of 76 novel B1 metallo-β-lactamases through large-scale screening of genomic and metagenomic data. Microbiome. 5:134. https://doi.org/10.1186/s40168-017-0353-8
  • Nachiket MP, Pal C, Gaikwad SS, Jonsson V, Kristiansson E, Larsson DGJ. (2017). Untreated urban waste contaminates Indian river sediments with resistance genes to last resort antibiotics. Water Res. 124:388. https://doi.org/10.1016/j.watres.2017.07.060
  • Bengtsson-Palme J, Larsson DGJ, Kristiansson E. (2017). Using metagenomics to investigate human and environmental resistomes. J Antimicrob Chemother. 72:2690. https://doi.org/10.1093/jac/dkx199
  • Näslund J, Fick J, Asker N, Ekman E, Larsson DGJ, Norrgren L. (2017). Diclofenac affects kidney histopathology in the three-spined stickleback (Gasterosteus aculeatus) at low µg/L concentrations. Aquat Toxicol. 189:87. https://doi.org/10.1016/j.aquatox.2017.05.017
  • Flach CF, Pal C, Svensson CJ, Kristiansson E, Östman M, Bengtsson-Palme J, Tysklind M, Larsson DGJ. (2017). Does antifouling paint select for antibiotic resistance? Sci Total Environ. 590–591:461. https://doi.org/10.1016/j.scitotenv.2017.01.213
  • Hao X*, Li X*, Pal C*, Hobman J, Rosen BP, Larsson DGJ, Saquib Q, Alwathnani HA, Zhu Y-G, Rensing C. (2017). Bacterial resistance to arsenic protects against protist killing. Biometals. 30:307. https://dx.doi.org/10.1007/s10534-017-0003-4 (*-co-first authors).
  • Pal C, Asiani K, Arya S, Rensing C, Stekel DJ, Larsson DGJ, Hobman JL. (2017). Metal resistance and its association with antibiotic resistance. Adv Microb Physiol. 70:261. ISBN: 9780128123867. https://doi.org/10.1016/bs.ampbs.2017.02.001


  • Marathe MP, Shetty SA, Shouche YS, Larsson DGJ. (2016). Limited bacterial diversity within a treatment plant receiving antibiotic-containing waste from bulk drug production. PloS One 11(11): e0165914. https://doi.org/10.1371/journal.pone.0165914
  • Bengtsson-Palme J, Larsson DGJ (2016). Why limit antibiotic pollution? The role of environmental selection in antibiotic resistance development. APUA Newsletter, 34:6.
  • Pal C, Bengtsson-Palme J, Kristiansson E, Larsson DGJ. (2016). The structure and diversity of human, animal and environmental resistomes. Microbiome. 4:54. https://doi.org/10.1186/s40168-016-0199-5
  • Bengtsson-Palme J, Hammarén R, Pal C, Östman M, Björlenius B, Flach C-F, Fick J, Kristiansson E, Tysklind M, Larsson DGJ. (2016). Elucidating selection processes for antibiotic resistance in sewage treatment plants using metagenomics. Sci Total Environ. 572:697. https://doi.org/10.1016/j.scitotenv.2016.06.228
  • De Roda Husman A-M, Larsson DGJ (2016). Risk assessment and risk management of antimicrobial resistance in the environment. AMR control 2016:104. Global Health Dynamics, UK. 
  • Rönnerstrand B, Jagers S, Larsson DGJ (2016). Who worries about antibiotic resistance? (In Swedish). In: Ekvilibrium (Eds. Henrik Oscarsson, Jonas Ohlsson and Maria Solevid). SOM-institutet, University of Gothenburg. ISBN 978-91-89673-35-9.
  • Larsson DGJ, Svennerholm A-M (2016). The role of antibacterial agents in the development of antibiotic resistance (in Swedish). Läkartidningen 2016;113:D44E.
  • Bengtsson-Palme J and Larsson DGJ. (2016) Time to limit antibiotic pollution. The medicine maker, April:17. (opinion paper) (pdf)
  • Lundström SV, Östman M, Bengtsson-Palme J, Rutgersson C, Thoudal M, Sircar T, Blanck H, Eriksson KM, Tysklind M, Flach CF, Larsson DGJ. (2016) Minimal selective concentrations of tetracycline in complex aquatic bacterial biofilms. Sci Total Environ. 553:587. https://doi.org/10.1016/j.scitotenv.2016.02.103
  • Jutkina J, Rutgersson C, Flach CF, Larsson DGJ. (2016). An assay for determining minimal concentrations of antibiotics that drive horizontal transfer of resistance. Sci Total Environ. 548–549:131. https://doi.org/10.1016/j.scitotenv.2016.01.044

  • Bengtsson-Palme J, Larsson DGJ. (2016). Concentrations of antibiotics predicted to select for resistant bacteria: Proposed limits for environmental regulation. Environ Int. 86:140. https://doi.org/10.1016/j.envint.2015.10.015


  • Johnning A, Kristiansson E, Fick J, Weijdegard B, Larsson DGJ. (2015) Resistance mutations in gyrA and parC are common in Escherichia communities of both fluoroquinolone-polluted and uncontaminated aquatic environments. Front. Microbiol. 6:1355. https://doi.org/10.3389/fmicb.2015.01355
  • Pal C, Bengtsson-Palme J, Kristiansson E, Larsson DGJ. (2015) Co-occurrence of resistance genes to antibiotics, biocides and metals reveals novel insights into their co-selection potential. BMC Genomics. 16:964. https://doi.org/10.1186/s12864-015-2153-5
  • Johnning A, Kristiansson E, Martin A, Marathe NP, Shouche YS, Johansson A, Larsson DGJ. (2015) Quinolone resistance mutations in the faecal microbiota of Swedish travellers to India. BMC Microbiology. 15:235. https://doi.org/10.1186/s12866-015-0574-6
  • Bengtsson-Palme J, Angelin M, Huss M, Kjellqvist S, Kristiansson E, Palmgren H, Larsson DGJ, Johansson A. (2015) The human gut microbiome as a transporter of antibiotic resistance genes between continents. Antimicrob Agents and Chemother. 59: 6551. doi: 10.1128/AAC.00933-15

  • Sandegren L, Salin K, Larsson DGJ. (2015) The environmental dimension of antibiotic resistance. In: Uppsala Health Summit – a world without antibiotics. Post-conference report. Pp 17-21. www.uppsalahealthsummit.se.
  • Flach CF, Johnning A, Nilsson I, Smalla K, Kristiansson E, Larsson DGJ. (2015) Isolation of novel IncA/C and IncN fluoroquinolone resistance plasmids from an antibiotic-polluted lake. J Antimicrob Chemother. 70:2709. doi: 10.1093/jac/dkv167
  • Bylander A, Gunnarsson L, Shao R, Billig H, Larsson DGJ. (2015) Progesterone-mediated effects on gene expression and oocyte-cumulus complex transport in the mouse fallopian tube. Reprod Biol Endocrinol. 13:40. doi: 10.1186/s12958-015-0038-8
  • Ågerstrand M, Berg C, Björlenius B, Breitholtz M, Brunstrom B,
    Fick J, Gunnarsson L, Larsson DGJ, Sumpter JP, Tysklind M, and Rudén C. (2015) Improving environmental risk assessment of human pharmaceuticals. Environ Sci Technol. 49:5336. DOI: 10.1021/acs.est.5b00302
  • Bengtsson-Palme J, Hartmann M, Eriksson KM, Pal C, Thorell K, Larsson DGJ, Nilsson RH. (2015) METAXA2 – Improved Identification and Taxonomic Classification of Small and Large Subunit rRNA in Metagenomic Data, Mol Ecol Resour, 15:1403. DOI: 10.1111/1755-0998.12399.
  • Carney Almroth BM, Gunnarsson LM, Cuklev F, Fick J, Kristiansson E, Larsson DGJ. (2015) Waterborne beclomethasone diproprionate affects the physiology of fish while its metabolite beclomethasone is not taken up. SciTotal Environ. 511:37.  doi:10.1016/j.scitotenv.2014.12.016
  • Bengtsson-Palme J, Larsson DGJ. (2015) Antibiotic resistance genes in the environment: prioritizing risks. Nature Reviews Microbiology. 13, 396. doi:10.1038/nrmicro3399-c-1
  • Larsson DGJ and Sandegren L. (2015) The environmental dimension of antibiotic resistance. In: Uppsala Health Summit – a world without antibiotics. Pre-conference report. Pp 16-19. www.uppsalahealthsummit.se.
  • Wernersson A-S et al (in total 46 authors). (2015) The European technical report on aquatic effect-based monitoring tools under the water framework directive. Environmental Sciences Europe. 27:7. doi:10.1186/s12302-015-0039-4.


  • Bengtsson-Palme J, Boulund F, Fick J, Kristiansson E, Larsson DGJ. (2014) Shotgun metagenomics reveals a wide array of antibiotic resistance genes and mobile elements in a polluted lake in India. Front. Microbiol. 5:648. doi: 10.3389/fmicb.2014.00648
  • Rutgersson C, Fick J, Marathe N, Kristiansson E, Janzon A, Angelin M, Johansson A, Shouche Y, Flach CF, Larsson DGJ. (2014) Fluoroquinolones and qnr genes in sediment, water, soil and human fecal flora in an environment polluted by manufacturing discharges. Environmental Science & Technology 48(14)):7825–32. http://dx.doi.org/10.1021/es501452a
  • Grabicova K, Lindberg RH, Östman M, Grabic R, Randak T, Larsson DGJ, Fick J. (2014) Tissue-specific bioconcentration of antidepressants in fish exposed to effluent from a municipal sewage treatment plant. Science of the Total Environment, 488-489, 46-50. doi:10.1016/j.scitotenv.2014.04.052
  • Brown JN, Samuelsson L, Bernardi G, Gooneratne R, Larsson DGJ. (2014) Aqueous and Lipid NMR Metabolomic Profiling of the Earthworm Aporrectodea caliginosa shows Potential as Indicators for Studying the Effects of Differing Landuses. Environmental Toxicology and Chemistry. Vol 33, 2313–22. http://dx.doi.org/10.1002/etc.2680
  • Pal C, Bengtsson-Palme J, Rensing C, Kristiansson E, Larsson DGJ. (2014) BacMet: antibacterial biocide and metal resistance genes database. Nucleic Acids Research, 42, D737-D743. doi: 10.1093/nar/gkt1252.
  • Graham DW, Collignon P, Davies J, Larsson DGJ, Snape J. (2014) Underappreciated role of regionally poor water quality on globally increasing antibiotic resistance. Environmental Science & Technology, vol 48, 11746−11747. http://doi.org/10.1021/es504206x
  • Larsson DGJ. (2014) Pollution from drug manufacturing: review and perspectives. Philosophical Transactions of the Royal Society B, 369: 20130571. http://dx.doi.org/10.1098/rstb.2013.0571
  • Kookana RS, Williams M, Boxall AB , Larsson DGJ, Gaw S, Choi K, Yamamoto H, Shashidhar T, Zhu Y-G, Carriquiriborde P. (2014) Potential Ecological Footprints of Active Pharmaceutical Ingredients: An Examination of Risk Factors in Low-, Middle-, and High-income Countries. Philosophical Transactions of the Royal Society B, 369: 20130586. http://dx.doi.org/10.1098/rstb.2013.0586
  • Larsson DGJ. (2014) Antibiotics and antibiotic resistance in the external environment (in Swedish). Chapter in a popular science book on Antibiotic resistance (Antibiotika - boten och hoten) within the publication series “Formas fokuserar”. ISBN 978-91-540-6082-5. Pp 63-72
  • Larsson DGJ. (2014) Antibiotics in the environment. Upsala Journal of Medical Sciences, 119(2), 108-112 doi:10.3109/03009734.2014.896438
  • Larsson DGJ and Greko C. (2014) Great drugs in the wrong place: risks for environmental effects and resistance promotion (in Swedish). Läkartidningen no 14, vol 111, pp 619-620. Online copy available here.
  • Larsson DGJ and Lööf L. (2014) Läkemedel i miljön. In: Läkemedelsboken 2014, edited and produced by the Swedish Medical Products Agency. Pp 1267-1279. Also available at www.lakemedelsboken.se


  • Flach CF, Boulund F, Kristiansson E, Larsson DGJ. (2013) Functional verification of computationally predicted qnr genes. Annals of Clinical Microbiology and Antimicrobials. 12:34 doi:10.1186/1476-0711-12-34.
  • Johnning A, Moore ERB, Svensson-Stadler L, Shouche YS, Larsson DGJ, Kristiansson E. (2013) The acquired genetic mechanisms of a multi-resistant bacterium isolated from a treatment plant receiving wastewater from antibiotic production. Appl. Environ. Microbiol., 79(23):7256. doi:10.1128/AEM.02141-13.
  • Marathe NP, Regina VR, Walujkar SA, Charan SS, Moore ERB, Charan SS, Moore ERB, Larsson DGJ, Shouche YS. (2013) A Treatment Plant Receiving Waste Water from Multiple Bulk Drug Manufacturers Is a Reservoir for Highly Multi-Drug Resistant Integron-Bearing Bacteria. PLoS ONE 8(10): e77310. doi:10.1371/journal.pone.0077310
  • Selvaraj KK, Shanmugam G, Sampath S, Larsson DGJ, Ramaswamy BR. (2013) GC-MS determination of bisphenol A and alkylphenol ethoxylates in the river water from India and their ecotoxicological risk assessment. Ecotoxicology and Environmental Safety. doi:10.1016/j.ecoenv.2013.09.006.
  • Shanmugam G, Sampath S, Selvaraj KK, Larsson DGJ, Ramaswamy BR. (2013) Non-steroidal anti inflammatory drugs in Indian rivers. Environmental Science and Pollution Research. doi:10.1007/s11356-013-1957-6
  • Bylander A, Lind K, Goksör M, Billig H, Larsson DGJ. (2013) The classical progesterone receptor mediates the rapid reduction of fallopian tube ciliary beat frequency by progesterone. Reproductive Biology and Endocrinology. 11:33. doi:10.1186/1477-7827-11-33
  • Kristiansson E, Österlund T, Gunnarsson G, Arne G, Larsson DGJ, Nerman O. (2013) A novel method for cross-species gene expression analysis. BMC Bioinformatics. 14:70. doi: 10.1186/1471-2105-14-70.
  • Asker N, Kristiansson E, Albertsson E, Larsson DGJ, Förlin L. (2013) Hepatic transcriptome profiling indicates differential mRNA expression of apoptosis and immune related genes in eelpout (Zoarces viviparus) caught at Göteborg harbor, Sweden. Aquatic Toxicology. 130–131:58-67. doi: 10.1016/j.aquatox.2012.12.017.
  • Rutgersson C, Gunnarsson L, Kristiansson E, Larsson DGJ. (2013) Oral exposure to industrial effluent with exceptionally high levels of drugs does not indicate acute toxic effects in rats. Environmental Toxicology and Chemistry. 32:577–584. doi: 10.1002/etc.2105.
  • Beijer K, Gao K, Jönsson M, Larsson DGJ, Brunström B, Brandt I. (2013) Effluent from drug manufacturing affects cytochrome P450 1 regulation and function in fish. Chemosphere 90: 1149–1157. doi: 10.1016/j.chemosphere.2012.09.023.
  • Kullgren A, Jutfelt F, Fontanillas R, Sundell K, Samuelsson LM, Wiklander K, Kling P, Koppe W, Larsson DGJ, Björnsson B-T, Jönsson E. (2013) The impact of temperature on the metabolome and endocrine metabolic signaling in Atlantic salmon (Salmo salar). Comparative Biochemistry and Physiology, Part A 164: 44–53. doi: 10.1016/j.cbpa.2012.10.005.
  • Ashbolt NJ, Amézquita A, Backhaus T, Borriello SP, Brandt KK, Collignon P, Coors A, Finley R, Gaze WH, Heberer T, Lawrence J, Larsson DGJ, McEwen SA, Ryan JJ, Schönfeld J, Silley P, Snape JR, van den Eede C, Topp E. (2013) Human health risk assessment (HHRA) for environmental development and transfer of antibiotic resistance. Environmental Health Perspectives 121:993-1001. doi:10.1289/ehp.1206316
  • Pruden A, Larsson DGJ*, Amézquita A, Collignon P, Brandt KK, Graham DW, Lazorchak JR, Suzuki S, Silley P, Snape JR, Topp E, Zhang T, Zhu Y-G. (2013) Management Options For Reducing The Release Of Antibiotics And Antibiotic Resistance Genes To The Environment. Environmental Health Perspectives. vol 121, pp 878-885. doi: 10.1289/ehp.1206446. *corresponding author and shared first author.
  • Finley RL, Collignon P, Larsson DGJ, McEwen SA, Li X-Z, Gaze WH, Wright GD, Reid-Smith R, Timinouni M, Ryan JJ, Woodland C, Graham DW, Topp E. (2013) The scourge of antibiotic resistance: the important role of the environment. Clinical Infectious Diseases. 57(5):704-710. doi:10.1093/cid/cit355
  • Gaze WH, Krone SM, Larsson DGJ, Li XZ, Robinson JA, Simonet P, Smalla K, Timinouni M, Topp E, Wellington EM, Wright GD, Zhu YG. (2013) Influence of humans on evolution and mobilization of environmental antibiotic resistome. Emerging Infectious Diseases. Vol 19 (7) Online report: doi:10.3201/eid1907.120871


  • Boulund F, Johnning A, Pereira MB, Larsson DGJ, Kristiansson E. (2012) A novel method to discover fluoroquinolone antibiotic resistance (qnr) genes in fragmented nucleotide sequences. BMC Genomics. 13:695. doi: 10.1186/1471-2164-13-695.
  • Albertsson A, Rad A, Sturve J, Larsson DGJ, Förlin L. (2012) Carbonyl reductase mRNA abundance and enzymatic activity as potential biomarkers of oxidative stress in marine fish. Marine Environmental Research. 80:56-61. doi: 10.1016/j.marenvres.2012.07.001.
  • Cuklev F, Fick J, Cvijovic M, Kristiansson E, Förlin L, Larsson DGJ. (2012) Does ketoprofen or diclofenac pose the lowest risk to fish? Journal of Hazardous Materials. 229-230:100-106. doi: 10.1016/j.jhazmat.2012.05.077.
  • Boxall ABA, Rudd MA, Brooks BW, Caldwell DJ, Choi K, Hickmann S, Innes E, Ostapyk K, Staveley JP, Verslycke T, Ankley GT, Beazley KF, Belanger SE, Berninger JP, Carriquiriborde P, Coors A, DeLeo PC, Dyer SD, Gagné F, Giesy JP, Hallstrom L, Karlsson M, Larsson DGJ, Lazorchak JM, Mastrocco F, McLaughlin A, McMaster ME, Meyerhoff RD, Parrott J, Snape JR, Murray-Smith R, Servos MR, Sibley PK, Straub JO, Szabo ND, Topp E, Tetreault GR, Trudeau VL, Van Der Kraak G. (2012) Pharmaceuticals and Personal Care Products in the Environment: What are the Big Questions? Environmental Health Perspectives. 120:1221-1229. doi: 10.1289/ehp.1104477.
  • Svahn S, Göransson U, El-Seedi H, Bohlin L, Larsson DGJ, Olsen B, Chryssanthou E. (2012) Antimicrobial activity of filamentous fungi isolated from highly antibiotic-contaminated river sediment. Infection Ecology and Epidemiology. Vol 2: 11591 - http://dx.doi.org/10.3402/iee.v2i0.11591
  • Cuklev F, Kristiansson E, Gunnarsson L, Cvijovic M, Rutgersson C, Fick J, Grabic R, Björlenius B, Larsson DGJ. (2012) Global hepatic gene expression in fish exposed to sewage effluents: A comparison of different treatment technologies. Science of the Total Environment. Vol 427-428: 106-114. doi: 10.1016/j.scitotenv.2012.04.009.
  • Roos V, Gunnarsson L, Fick J, Larsson DGJ, Rudén C. (2012) Prioritising pharmaceuticals for environmental risk assessment: Towards adequate and feasible first-tier selection. Science of the Total Environment. Vol 421-422:102-10. Recognized by the Society of Toxicology in 2013 to be among the “Top 10 Papers Advancing the Science of Risk Assessment in 2012”.
  • Gunnarsson L, Kristiansson E and Larsson DGJ. (2012)Environmental Comparative Pharmacology: Theory and application. In: Emerging Topics in Ecotoxicology, 1, Volume 4, Human Pharmaceuticals in the Environment - Current and Future Perspectives. Eds: B Brooks, D Huggett. Springer Verlag. ISBN 978-1-4614-3419-1. Pp 85-108
  • Janzon A, Kristiansson K, Larsson DGJ. (2012) Environmental microbial communities living under very high antibiotic selection pressure. Invited book chapter in: Antimicrobial Resistance in the Environment. First Edition. Eds. Montforts HMM, Keen PL. Wiley & Blackwell. Pp 483-501.
  • Larsson DGJ. (2012) Utsläpp från läkemedelsindustri påverkar miljön - Antibiotikautsläpp riskerar också vår egen hälsa. Invited review in Swedish. Läkartidningen, no 14-15, vol 109, pp 750-753. http://www.lakartidningen.se/07engine.php?articleId=18064
  • Brandt I, Breitholtz M, la Cour Jansen J, Liljelund K, Larsson DGJ, Rudén C, Tysklind M. (2012) Pharmaceuticals in a Healthy Environment. ISBN: 978-91-978836-2-7. Elanders, Sverige AB Stockholm. 71pp.


  • Cuklev F, Kristiansson K, Fick J, Asker N, Förlin L, Larsson DGJ. (2011) Diclofenac in fish - blood plasma levels similar to human therapeutic levels affect global hepatic gene expression. Environmental Toxicology and Chemistry. 30 (9): 2126–2134.
  • Lennquist A, Asker N, Kristiansson E, Brenthel A, Björnsson B-T, Kling P, Larsson DGJ, Förlin L. (2011) Physiology and gene expression in rainbow trout (Onchorhyncus mykiss) after long- term exposure to the new antifoulant medetomidine. Comparative Biochemistry and Physiology part C. 154 (3) pp. 234-24.
  • Kristiansson E, Fick J, Janzon A, Grabic R, Rutgersson C, Weijdegård B, Söderström H, Larsson DGJ. (2011)Pyrosequencing of antibiotic-contaminated river sediments reveals high levels of resistance and gene transfer elements. PLoS ONE 6(2): e17038. doi: 10.1371/journal.pone.0017038.(Highlight in Nature 2011. doi:10.1038/news.2011.46).
  • Holmberg A, Fogel J, Albertsson E, Fick J, Brown JN, Paxéus N, Förlin L, Johnsson J, Larsson DGJ. (2011) Does waterborne citalopram affect the aggressive and sexual behaviour of rainbow trout and guppy? Journal of Hazardous Materials. 187(1-3):596-9.
  • Samuelsson LM, Björlenius B, Förlin L and Larsson DGJ. (2011) Reproducible 1H NMR-based metabolomic responses in fish exposed to different sewage effluents in two separate studies. Environmental Science and Technology. 45 (4), pp 1703–1710
  • Ramaswamy BR, Shanmugam G, Velu G, Rengarajan B, and Larsson DGJ. (2011) GC-MS analysis and ecotoxicological risk assessment of triclosan, carbamazepine and parabens in Indian rivers. Journal of Hazardous Materials. 186: 1586–1593
  • Larsson DGJ and Lööf L. (2011) Läkemedel i miljön. Invited book chapter (In Swedish) in “Läkemedelsboken 2011-2012”, edited and produced by the Swedish Medical Products Agency. Pp 1182-1193. Also available at www.lakemedelsboken.se


  • Kullgren A, Samuelsson L, Larsson DGJ, Björnsson Th, Jönsson Bergman E. 2010. A metabolomics approach to elucidate effects of food deprivation in juvenile rainbow trout (Oncorhynchus mykiss). American Journal of Physiology - Regulatory, Integrative and Comparative Physiology. 299: R1440-R1448.
  • Fick J, Lindberg RH, Tysklind M, Larsson DGJ. 2010. Predicted Critical Environmental Concentrations for 500 Pharmaceuticals. Regulatory Toxicology and Pharmacology. 58: 516-523.
  • Bylander A, Nutu M, Wellander R, Goksör M, Billig H, Larsson DGJ. 2010. Rapid effects of progesterone on ciliary beat frequency in the mouse fallopian tube. Reproductive Biology and Endocrinology. 8:48.
  • Fick J, Lindberg RH, Parkkonen J, Arvidsson B, Larsson DGJ. 2010. Therapeutic levels of levonorgestrel detected in blood plasma of fish: Results from screening rainbow trout exposed to treated sewage effluents. Environmental Science and Technology. 44:2661-2666.
  • Albertsson E, Larsson DGJ and Förlin L. 2010. Induction of hepatic carbonyl reductase/20β-hydroxysteroid dehydrogenase mRNA in rainbow trout downstream from sewage treatment works – possible roles of aryl hydrocarbon receptor agonists and oxidative stress. Aquatic Toxicology. 97:243-249.
  • Friberg PA, Larsson DGJ and Billig H.2010. Transcriptional effects of progesterone receptor antagonist in rat granulosa cells. Molecular and Cellular Endocrinology 315:121-130.
  • Nutu M, Weijdegård B, Thomas P, Thurin-Kjellberg A, Billig H and Larsson DGJ. 2009. Distribution and hormonal regulation of membrane progesterone receptors beta and gamma in ciliated epithelial cells of mouse and human fallopian tubes. Reproductive Biology and Endocrinology 7:89.
  • Cuklev F, Gunnarsson L, Larsson DGJ. 2010. Genomics as a guide to assess environmental risks of pharmaceuticals. In: Towards sustainable pharmacy in a healthy society. Pp 58-71. ISBN 978-91-978836-0-3.
  • Fick J, Grabic R, Lindberg RH, Larsson DGJ, Tysklind M. 2010. Bioconcentration of pharmaceuticals. In: Towards sustainable pharmacy in a healthy society. Pp 36-45. ISBN 978-91-978836-0-3.
  • Larsson DGJ. 2010. Release of active pharmaceutical ingredients from manufacturing sites – need for new management strategies. Integrated Environmental Assessment and Management. 6 (1):184-186.

2009 and before

  • Kristiansson E, Asker N, Förlin F and Larsson DGJ. 2009. Characterization of the Zoarces viviparus liver transcriptome using massively parallel pyrosequencing. BMC Genomics. 10(1):345
  • Gunnarsson L, Kristiansson E, Rutgersson C, Sturve J, Fick J, Förlin L and Larsson DGJ. 2009. Pharmaceutical industry effluent diluted 1:500 affects global gene expression, CYP1A activity and plasma phosphate in fish. Environmental Toxicology and Chemistry 28:2639-2647
  • Gunnarsson L, Adolfsson-Erici M., Björlenius B, Rutgersson C., Förlin L., Larsson D.G.J. 2009. Comparison of six different sewage treatment technologies - reduction of estrogenic substances and effects on gene expression in exposed male fish. Science of the Total Environment 407:5235–5242.
  • Fick J, Söderström H, Lindberg RH, Chau DNP, Tysklind M, Larsson DGJ. 2009. Contamination of surface, ground, and drinking water from pharmaceutical production. Environmental Toxicology and Chemistry. 28:2522-2527.
  • Larsson DGJ and Fick J. 2009. Transpararency throughout the production chain – a way to reduce pollution from the manufacturing of pharmaceuticals. Regulatory Toxicology and Pharmacology. 53:161-163. doi: 10.1016/j.yrtph.2009.01.008. (Highlight in Nature 2009. 457:640-641).
  • Carlsson G, Örn S and Larsson DGJ. 2009. Effluent from bulk drug production is toxic to aquatic vertebrates. Environmental Toxicology and Chemistry 28:2656-2662. doi: 10.1897/08-524. (Highlight in Nature 2009. 457:640-641). 
  • Friberg P.A., Larsson D.G., Billig H., 2009. Dominant role of nuclear progesterone receptor in the control of rat periovulatory granulosa cell apoptosis. Biol Reprod. 80, 1160-1167.
  • Rudén C, Brandt I, Breitholtz M, Fick J, la Cour Jansen J, Larsson DGJ, Tysklind M. 2009. Feminized Fish and Vulnerable Vultures – Pharmaceuticals as Environmental Pollutants Require Novel Testing Approches. Pp 148-165. In: A healthy future – Pharmaceuticals in a Sustainable Society. Eds Bengtsson B-E et al. Apoteket AB, Stockholm Sweden. ISBN:2184-01. Available in both English and Swedish.
  • Gunnarsson L, Jauhiainen A, Kristiansson E, Nerman O, Larsson DGJ. 2008. Evolutionary conservation of human drug targets in organisms used for environmental risk assessments. Environmental Science and Technology 42:5807-5813. (Highlight in Environ. Sci. Technol., 2008, 42: 5382–5383, and received the “AstraZeneca Award for the best publication in risk assessment, modeling and theoretical studies” in 2008).

  • Larsson DGJ. 2008. Drug production facilities – an overlooked discharge source for pharmaceuticals to the environment. In Kümmerer K, ed, Pharmaceuticals in the Environment. Sources, Fate, Effects, and Risks. Springer, New York, NY, USA, pp 37-42.
  • Samuelsson L.M and Larsson D.G.J. 2008. Contributions from metabolomics to fish research. Molecular Biosystems 4:974–979
  • Larsson DGJ, de Pedro C, Paxeus N. 2007. Effluent from drug manufactures contains extremely high levels of pharmaceuticals. Journal of Hazardous Materials. 148, 751-755. (Highlight in Nature 2009. 457:640-641).
  • Brown JN, Paxeus N, Forlin L and Larsson DGJ. 2007. Variations in bioconcentration of human pharmaceuticals from sewage effluents into fish blood plasma. Environmental Toxicology and Pharmacology. 24, 267-274.
  • Albertsson E., Kling P., Gunnarsson L., Larsson D.G.J. and Förlin L. 2007. Proteomic analyses indicate induction of hepatic carbonyl reductase/20β-hydroxysteroid dehydrogenase B in rainbow trout exposed to sewage effluent. Ecotoxicology and Environmental Safety. 68, 33-39.
  • Gunnarsson L., Kristiansson E., Förlin L., Nerman O. and Larsson D.G.J. 2007. Sensitive and robust gene expression changes in fish exposed to estrogen: a microarray approach. BMC Genomics 8, 149.
  • Friberg P.A., Larsson D.G.J., Rung E. and Billig H. 2007. Apoptotic effects of a progesterone receptor antagonist on rat granulosa cells are not mediated via reduced cholesterol synthesis and protein isoprenylation. Molecular Reproduction and Development. 74, 1317-1326.
  • Nutu M., Weijdegård B., Thomas P., Bergh C., Thurin-Kjellberg A., Pang Y., Billig H. and Larsson D.G.J. 2007. Membrane progesterone receptor gamma: tissue distribution and expression in ciliated cells in the fallopian tube. Molecular Reproduction and Development. 74:843-850.
  • Tyler C.R., Filby A., Iguchi T., Kramer V, Larsson D.G.J., van Aggelen G., van Leeuwen C., Viant M., Tillitt D. 2007. Application of Genomics to Tiered Testing. In: Molecular Biology and Risk Assessment: Evaluation of the Potential Roles of Genomics in Regulatory Ecotoxicology (ed. Ankley G). Society of Environmental Toxicology and Chemistry. CRC Press, New York pp33-62.
  • Carvan MJ, Gallagher E, Goksoyr A, Hahn M, Larsson DGJ and Wirgin I. 2007. Fish models in toxicology: a roundtable discussion. Zebrafish. 4, 9-20.
  • Larsson D.G.J., Fredriksson S., Sandblom E., Paxeus N. and Axelsson M. 2006. Is heart rate in fish a sensitive indicator to evaluate acute effects of β-blockers in surface water? Environmental Toxicology and Pharmacology 22, 338-340.
  • Samuelsson L., Förlin L., Karlsson G., Adolfsson-Erici M. and Larsson D.G.J. 2006. Using NMR metabolomics to identify responses of an environmental estrogen in blood plasma of fish. Aquatic Toxicology, 78, 341-349.
  • Larsson D.G.J., Adolfsson-Erici M. and Thomas P. 2006. Characterization of putative ligands for a fish gonadal androgen receptor in pulp mill effluent. Environmental Toxicology and Chemistry 25, 269-27
  • Markström E., Friberg P.A., Shao R., Larsson D.G.J., Nielsen E.C., Svensson P.-A., Carlsson B., Carlsson L.M.S and Billig H. 2005. Progesterone receptor antagonists and statins decrease de novo cholesterol synthesis and increase apoptosis in rat and human periovulatory granulosa cells in vitro. Biology of Reproduction. 72, 538-545.
  • Larsson J., Norrgren L. and Förlin L. 2005. (English revised version 2006). Hormones and Endocrine disrupting substances in the Environment.Chapter 6, p 84-103. (Invited review) In: Environment and Pharmaceuticals (ed. Wall T.). Apoteksbolaget, Stockholm. Available in English or Swedish from Apoteksbolaget AB, Sweden.
  • Goksøyr A., Arukwe A., Larsson D.G.J., Cajaraville M.P., Hauser L., Nilsen B.M., Lowe D. and Matthiessen P. 2003. Molecular/cellular processes and the impact on reproduction. In: Effects of pollution on fish. Blackwell Science Ltd. pp 179-220. ISBN 0-632-06406-4.
  • Larsson D.G.J., Sperry T. and Thomas P. 2002. Regulation of androgen receptors in Atlantic croaker brains by testosterone and estradiol. General and Comparative Endocrinology. 128, 224-230.
  • Larsson D.G.J. and Förlin L. 2002. Male-biased sex ratios of fish embryos near a pulp mill: Temporary recovery after a short-term shutdown. Environmental Health Perspectives. 110, 739-742.
  • Larsson D.G.J., Kinnberg K., Sturve J., Stephensen E., Skön M. and Förlin L. 2002. Studies of masculinization, detoxification and oxidative stress responses in guppies (Poecilia reticulata) exposed to effluent from a pulp mill. Ecotoxicology and Environmental Safety. 52, 13-20.
  • Larsson D.G.J., Mayer I., Hyllner S.-J. and Förlin L. 2002. Seasonal variations of vitelline envelope proteins, vitellogenin and reproductive steroids in male and female eelpout (Zoarces viviparus). General and Comparative Endocrinology 125, 184-196.
  • Larsson D.G.J. 2000. PhD-Thesis: Endocrine disruption in fish: sex ratios, secondary sex characters and estrogen-induced proteins. Göteborg University. ISBN 91-628-4104-1.
  • Larsson D.G.J., Hällman H. and Förlin L. 2000. More male fish embryos near a pulp mill. Environmental Toxicology and Chemistry 19 (12), 2911–2917.
  • Livingstone D.R., Mitchelmore C.S., Peters L.D., O’Hara S.C.M., Shaw J., Chesman B., MacEvoy J., Ronisz D., Larsson D.G.J., and Förlin, L. 2000. Development of hepatic CYP1A and blood vitellogenin in eel (Anguilla anguilla) for use as biomarkers in the Thames estuary, UK. Marine Environmental Research, 50, 367-371.
  • Larsson D.G.J., Adolfsson-Erici M., Parkkonen J., Pettersson, M., Berg H., Olsson P.-E. and Förlin L. 1999. Ethinyloestradiol - an undesired fish contraceptive? Aquatic Toxicology 45 (2-3), 91-97.
  • Ronisz D., Larsson D.G.J. and Förlin, L. 1999. Seasonal variations in the activities of selected hepatic biotransformation and antioxidant enzymes in eelpout (Zoarces viviparus). Comparative Biochemistry and Physiology 124C, 271-279.
  • Norrgren, L., Blom, A., Andersson, P.L., Börjesson, H., Larsson, D.G.J. and Olsson, P.-E. 1999. Effects of potential xenoestrogens (DEHP, nonylphenol and PCB) on sexual differentiation in juvenile Atlantic salmon (Salmo salar). Aquatic Ecosystem Health and Management 2, 311-317.
  • Larsson D.G.J., Mylonas C.C., Zohar Y. and Crim L.W. 1997. Gonadotropin releasing hormone-analogue (GnRH-A) induces multiple ovulations of high quality eggs in a cold-water batch-spawning teleost, the yellowtail flounder (Pleuronectes ferrugineus). Canadian Journal of Fisheries an Aquatic Sciences 54 (9), 1957-196.
  • Hyllner S.J., Fernandez-Palacios Barber H., Larsson D.G.J. and Haux C. 1995. Amino acid composition and endocrine control of vitelline envelope proteins in European sea bass (Dicentrarchus labrax) and gilthead sea bream (Sparus aurata). Molecular Reproduction and Development 41, 339-347.
  • Larsson D.G.J., Hyllner S.J. and Haux C. 1994. Induction of vitelline envelope proteins by estradiol-17 in ten teleost species. General and Comparative Endocrinology 96, 445-450.



Joakim Larsson

Department of Infectious Diseases, Institute of Biomedicine, University of Gothenburg, Guldhedsgatan 10, SE-413 46, Göteborg

Guldhedsgatan 10a, 5th floor

+46 (0) 31 342 4625

Sidansvarig: Dan Baeckström|Sidan uppdaterades: 2017-11-22

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