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Viral infections of the central nervous system

Marie Studahl

Contact Information | List of Publications

The project involves clinical studies of viral infections of the central nervous system (CNS) in children and adults: varicella zoster virus (VZV), herpes simplex encephalitis (HSE), herpes simplex virus type 2 (HSV-2) meningitis, and tick-borne encephalitis (TBE).
The research focuses on improving diagnosis with quantitative PCR and intrathecal antibodies and on performing studies on neuroimaging as well as biochemical markers in cerebrospinal fluid and serum in correlation to clinical outcome. The association between VZV and acute ischaemic stroke is investigated. Treatment studies have been performed in HSE and HSV-2 meningitis and future studies are planned.
The main aims are to improve diagnostics in cooperation with the Virology laboratory, to develop specific asessments for different CNS infections and rehabilitation programmes in order to diminish neurological sequels in cooperation with Neurorehabilitation Department and perform treatment studies at the Department of Infectious Diseases.


On-going studies

  • Aciclovir concentrations and viral resistance in patients with viral CNS infections treated with aciclovir i.v or valaciclovir orally.
  • Biomarkers, both biochemical and virological, and neuroimaging in relation to neurological and neuropsychological outcome in viral CNS infections.
  • VZV in association to acute ischaemic stroke.
  • Burden of CNS viral infections.
  • Evaluation of neurocognitive questionnaires for TBE.
  • Genetic predisposition in CNS herpes virus infections.
     

 

Group Members

Marie StudahlM.D, Ph.D, group leader, associate professor
Anna Grahn M.D, Ph.D
Malin Veje M.D, Ph.D student
Johan Lindström, M.D, Ph.D student
 

Sidansvarig: Dan Baeckström|Sidan uppdaterades: 2016-02-26
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