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Rune Andersson's research groups

Contact Information | List of Publications

Global Health Group  |  Severe Sepsis Group

Global Health Group

 1. Invasive pneumococcal infections

We have ongoing studies of pneumococcal infections in Kazakhstan, Tanzania, and planned studies in Ethiopia.
Pneumonia is a leading cause of death in young children worldwide, and the most common cause is the bacterium pneumococcus. Ethiopia and DR Congo are among the 10 countries with the highest disease burden. In Ethiopia the pneumococcal conjugate vaccine to infants was introduced in 2011, in Tanzania and D.R. Congo 2013. From Tanzania and Ethiopia there is limited data on the burden of pneumococcal infections in the population before the vaccination era, whereas in D.R. Congo, no one has studied the potential effects of the vaccine. In Tanzania we have an ongoing study of serotypes of pneumococci isolated from nasopharynx of healthy children and children with pneumonia after start of vaccination
Dr Archippe M.Birindwa, Bukavu, pediatrician from Bukavu, Congo is PhD student at SA from January 2014 on study of pneumococcal infections and carriers of pneumococci in nasopharynx before and after vaccination with conjugate pneumococcal vaccine.
Indira Karibayeva, Almaty, Kazakhstan is epidemiologist, in a PhD project studying the disease burden of pneumococcal infections in Kazakhstan before and after childhood vaccination with conjugate vaccine.

Indoor air pollution has been reported to be a leading cause of morbidity in low income countries where the food is often cooked on open fire with insufficient ventilation. The air quality can be determined by measuring the carbon monoxide (CO) concentration since CO is a known tracer of incomplete combustion. Interventions with better ovens, less toxic fuels and better ventilated kitchens are very important. We have established cooperation with the Center for Atmospheric Science, Department of Chemistry and Molecular Biology, University of Gothenburg; School of Public Health and Ethiopian Institute of Architecture, Building Construction and City Development (EiABC) at the Addis Ababa University, Ethiopia; Dept of Community Medicine at Kilimanjaro Christian Medical Centre (KCMC) and Kilimanjaro Christian Medical University College (KCMU Co), Moshi, Tanzania.

Pneumococci avoid phagocytosis and elimination by the immune system by its capsule, but other mechanisms may be involved in this virulence pattern as well. We have shown that pneumococci which autolyse, i.e. undergo fragmentation, inhibit production of cytokines that activate and enhance the killing capacity of phagocytes. We think that fragments generated by autolysis inhibit expression of genes important for phagocyte activation, and that microRNA is involved in such gene regulation. By sacrificing a less vital portion of the pneumococcal population, the chance of survival for the remaining bacteria would increase, thus increasing the overall infectious capacity of the pneumococcus. Identification of additional virulence factors may prove valuable for development of new treatment strategies.

Researchers:
Rune Andersson, Professor in global health, MD, PhD, specialist infectious diseases, Sahlgrenska Academy, University of Gothenburg, Sweden
Susann Skovbjerg, MD, PhD, specialist in Clinical Bacteriology, Sahlgrenska Academy, University of Gothenburg, Sweden
Erik Backhaus, MD, PhD, specialist Infectious diseases, Skaraborg Hospital. Skövde, Sweden
Rickard Nordén, Microbiologist, PhD, Department of Virology, Sahlgrenska Academy, University of Gothenburg, Sweden
Matilda Emgård, Medical student, planned PhD student,Sahlgrenska Academy, University of Gothenburg, Sweden
Archippe M.Birindwa, Bukavu, pediatrician from Bukavu, Congo is PhD student at SA
Indira Karibayeva, Almaty, Kazakhstan ,epidemiologist,PhD student in Almaty with Rune Andersson as co-supervisor.
Mattias Hallqvist, Professor in Atmospheric Chemistry, Department of Chemistry and Molecular Biology, University of Gothenburg, Sweden
Johan Boman, Professor in Atmospheric Science, Department of Chemistry and Molecular Biology, University of Gothenburg, Sweden
Araya Asfaw, Associate Professor, PhD Physics, Director the Horn of Africa Regional Environment Centre and Network (HoA-REC&N) at the Addis Ababa University, Ethiopia.
Abera Kume MD PhD, Associate Professor, School of Public Health, Department of Preventive Medicine - Environmental Health Unit, Addis Ababa University
Fikre Enquoselassie PhD, Associate Professor, and Head Department of Preventive Medicine, School of Public Health, Department of Preventive Medicine, Addis Ababa university
Adamu Addissie MD MPH MA, Assistant Professor, School of Public Health, Department of Preventive Medicine - Epidemiology Unit ,Addis Ababa University, Ethiopia
Denamo Addissie Nuramo, MSc(Construction Technology and Management), Chair Ethiopian Institute of Architecture, Building Construction and City Development (EiABC) at the Addis Ababa University, Ethiopia (http://eiabc.edu.et/).
Sia Msuya, MD, PhD, Assistant Head, Dept of Community Medicine at Kilimanjaro Christian Medical Centre (KCMC)and Kilimanjaro Christian Medical University College (KCMU Co), Moshi, Tanzania
Balthazar Nyombi, PhD, Head of the Clinical Laboratory at KCMC and KCMU Co, Moshi, Tanzania
Rune Nathaniel Philemon, MD, Paediatrician, Department of Paediatrics at KCMC and KCMU Co, Moshi, Tanzania
Archippe M. Birindwa, Bukavu, D.R. of Congo ,MD, Specialist in Paediatrics, PhD student Gothenburg University from January 2014.
Margaretha L. Sariko, Master thesis student, Laboratory technician, Microbiological Laboratory, KCMC, Moshi, Tanzania


2. Prevention and treatment of HIV in Xinjiang, China.

The Xinjiang province in western China has severe problems with HIV, hepatitis B and C connected to drug trafficking and sex work along the ancient silk road. Co-infections with tuberculosis are also common.
In the PhD project by Rena Maimaiti we study the level of knowledge on HIV and risk behaviour among students and pregnant women, quality of life among patients on antiretroviral treatment and coinfections of tuberculosis and hepatitis in HIV positive patients.

Group members:
Rune Andersson, Professor in global health, MD, PhD, specialist infectious diseases, Sahlgrenska Academy, Guest professor at Xinjiang Medical University.
Rena Maimaiti, MD, PhD student at SA, specialist in paediatrics at Xinjinag Medical University,Urumqi,China
Yuexin Zhang, MD, PhD, professor at the Department of Infectious Diseases, Xinjinag Medical University,Urumqi, China

 

3.HIV among immigrants to Sweden

About half of the HIV positive patients in Sweden are immigrants. In a PhD- project started at the Nordic School of Public Health (NHV) the situation for the immigrants with HIV is studied with focus on the support and problems in contact with the health care. Patients and health care workers in Western Sweden are interviewed. Because of the close of NHV the project is transferred to the Gothenburg University with registration of the PhD student 2014-05-22.

Group members:
Manijeh Mehdiyar, PhD student at Inst. of Biomedicine, Sahlgrenska Academy.
Rune Andersson, Professor in global health, MD, PhD, specialist infectious diseases, Sahlgrenska Academy, main supervisor
Katarina Hjelm,Professor, Department of Social Wellfare, Linköping University. Co-supervisor
Lene Povlsen, docent NHV, main supervisor during the period at NHV
 

 

Severe Sepsis Group

More people die in septicaemia than in myocardial infarctions, but do not in general get as rapid acute care. Delays in appropriate care significantly increase mortality and organ failure.
We have studied the epidemiology, outcome, virulence factors and serological response of invasive Staphylococcus aureus infections in Skaraborg County (population about 250,000) in a prospective study during two years. As control group we had healthy persons with and without carrying staphylococci in the nose.
We performed a prospective study in Skaraborg 2011 -2012on the clinical care and diagnostics of patients with sepsis with Dr Lars Ljungström as PhD –student.
Analysis of data is ongoing.
Researchers:
Rune Andersson, Professor in global health, MD, PhD, specialist infectious diseases, Sahlgrenska Academy, University of Gothenburg, Sweden
Gunnar Jacobsson, MD, PhD, specialist in infectious diseases at Skaraborg Hospital, Skövde
Lars Ljungström, PhD student, specialist in infectious diseases at Skaraborg Hospital, Skövde

Sidansvarig: Dan Baeckström|Sidan uppdaterades: 2016-02-26
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