Eva Jennische research group
In this project we are studying the protein Antisecretory Factor (AF/S5a) which was identified and cloned in our group 1995. AF has potent anti-inflammatory and anti-secretory effects. AF is activated after exposure to bacterial toxins and after intake of specified food components. Our clinical studies have shown that regimes aiming at increasing AF-activity is beneficial in diseases in which inflammation and/or secretory disturbances are important, e.g. inflammatory bowel disease (IBD), Meniere`s disease, infant diarrhoea or mastitis.
AF has a moleular weight of 43 kD and the active part is an eight amino acid long sequense in the N-terminal part of the protein. A somewhat longer peptide, AF-16, is stable and is used for experimental studies. Our present work aims at clarifying the mechanism of action for AF and at identifying further patient groups which might benefit from AF-therapy.