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Molecular Mechanisms of DNA Replication in Human Mitochondria

 

 

Maria Falkenberg

Contact Information | List of Publications

Selected recent publications

 

Mitochondria are required to convert food into usable energy forms and every cell contains thousands of them. Unlike most other cellular compartments, mitochondria have their own genomes (mtDNA) that in mammals encode for 13 of the about 90 proteins present in the respiratory chain. The existence of a separate mtDNA genome is explained by the widely accepted endosymbiotic theory, according to which the mitochondrion developed from an α-proteobacterium. During the course of time, ancestral bacterial genes have been transferred from the mitochondrial to the nuclear genome, which explains why all proteins necessary for mtDNA replication, as well as transcription and translation of mtDNA genes, are encoded in the nucleus. Mutations in nuclear-encoded proteins required for mtDNA maintenance are an important cause of neurodegeneration and muscle diseases. Mitochondrial dysfunction is also associated with common age-associated diseases (e.g. diabetes mellitus type II and Parkinson disease).


In the laboratory we are investigating the basic mechanisms of human mtDNA replication and how this process is regulated. In addition, we address the functional consequences of disease-causing mutations in genes required for mtDNA maintenance. Much of the work is performed using in vitro biochemistry and reconstituted systems for mammalian mtDNA replication, using different types of artificial templates and recombinant proteins.

 

 

Group members

Maria Falkenberg, Professor
Ali Al-Behadili,
PhD student
Anna-Karin Berglund, PhD

Emily Hoberg, BMA
Berti Macao, PhD
Majda Mehmedovic, PhD student

Yazh Muthukumar, PhD
Örjan Persson, PhD
Anna Wramstedt, PhD student
Xie Xie, PhD

Sidansvarig: Dan Baeckström|Sidan uppdaterades: 2016-02-29
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