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Molecular Mechanisms of DNA Replication in Human Mitochondria

Maria Falkenberg

Contact Information | List of Publications

Selected recent publications

 

Mitochondria are required to convert food into usable energy forms and every cell contains thousands of them. Unlike most other cellular compartments, mitochondria have their own genomes (mtDNA) that in mammals encode 13 of the about 90 proteins present in the respiratory chain. The existence of a separate mtDNA genome is explained by the widely accepted endosymbiotic theory, according to which the mitochondrion developed from an α-proteobacterium. During the course of time, ancestral bacterial genes have been transferred from the mitochondrial to the nuclear genome, which explains why all proteins necessary for mtDNA replication, as well as transcription and translation of mtDNA genes, are encoded in the nucleus. Mutations in nuclear-encoded proteins required for mtDNA maintenance are an important cause of neurodegeneration and muscle diseases. Mitochondrial dysfunction is also associated with common age-associated diseases (e.g. diabetes mellitus type II and Parkinson disease).


In the laboratory we are investigating the basic mechanisms of human mtDNA replication and how this process is regulated. In addition, we address the functional consequences of disease-causing mutations in genes required for mtDNA maintenance. Much of the work is performed using in vitro biochemistry and reconstituted systems for mammalian mtDNA replication, using different types of artificial templates and recombinant proteins.

 

 

Group Members

Maria Falkenberg, Professor
Ali Al-Behadili
, PhD student
Anna-Karin Berglund, PhD

Hector Diaz, PhD
Emily Hoberg, BMA
Bertil Macao, PhD
Majda Mehmedovic, PhD student

Monica Olsson, Assoc. Researcher
Örjan Persson, PhD
Anna Wramstedt, PhD student
Xie Xie, PhD

Recent News and Events

05-06-2017 Last chance to apply for a new postdoc position in the group

14-05-2017 We say farewell to Yazh with Sunday Brunch at the Clarion Post hotel

13-05-2017 Meet us at the Science Festival at the Gothenburg Garden Society

10-05-2017 Wenner-Gren Distinguished Lecture by John Diffley: How our genomes are copied. Hosted by Maria Falkenberg and Per Elias

2016 REMIX Innovative Training Network launches, PhD position available

30-9-2016 Meet us at the European Researchers' night at the Gothenburg Maritime Museum

2015 Maria Falkenberg elected to the Royal Swedish Academy of Sciences

2015 Monica Olsson receives visit from Nobel Laureate Tomas Lindahl 

2015 Maria Falkenberg receives ERC Consolidator grant

Sidansvarig: Dan Baeckström|Sidan uppdaterades: 2017-06-01
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