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Thyroid development and cancer

Mikael Nilsson research group

Thyroid dysgenesis and thyroid cancer are the most common developmental defects and tumours of the endocrine system with great impacts on public health and medicine. We investigate basic mechanisms of the pathogenesis and potential treatment of these diseases taking the advantage of genetic mouse models and 3D organotypic cell cultures. Current issues of interest concern: identification of the embryonic origin and developmental regulation of endocrine progenitor cells; search for novel biomarkers of thyroid cancer subtypes shared by embryonic and cancer cells; response to and consequences of DNA damage in foetal and young thyroid, in particular those generated from exposure to radioiodine; improvement of radioiodine therapy based on re-expression of the sodium/iodide symporter in tumour cells.

Group members

Mikael Nilsson MD, PhD, group leader, Professor
Henrik Fagman MD, PhD
Camilla Ingeson MSci, PhD student
Shawn Liang, MSci, PhD student
Ellen Johansson, MD
Therese Carlsson, Technician

Sidansvarig: Dan Baeckström|Sidan uppdaterades: 2011-03-09
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