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Susann Teneberg research group

Molecular protein-carbohydrate interactions in infection and immunity

For several global infectious diseases there is no effective treatment available, and a situation with increasing resistance against antibiotics is today rapidly emerging. The current project aims at characterization of microbial virulence factors that are potential targets for novel forms of antimicrobial therapies. The adhesion of a microbe to host cell is one such target, since the adherence occurs early in infection and often involves specific interactions between microbial proteins and target cell surface glycoconjugates. The project aims at characterizing essential microbe-host protein-carbohydrate interactions to a level allowing the development of new anti-infection therapeutics. The studies are focused on three main parts:

  1. Identification of microbial glycoconjugate receptors: Binding assays, isolation and structural characterization of binding-active glycoconjugates by mass spectrometry and NMR, and definition of receptor epitopes for pathogenic bacteria, bacterial toxins and viruses.
     
  2. Adhesin identification by using identified saccharide receptor in an affinity proteomics approach, or using deletion mutants of bacterial surface proteins.
     
  3. High-resolution studies of protein-carbohydrate complexes.
     

Group members

Susann Teneberg MD PhD, group leader, Professor
Jonas Ångström, PhD, Associate professor
Marianne Longard, technician
John Benktander, PhD student
Erik Valis, medical student

Sidansvarig: Dan Baeckström|Sidan uppdaterades: 2011-05-10
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