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Lymphocyte recruitment to gastrointestinal tissues


CD4 T cells (green surface staining) and FoxP3 regulatory T cells (green surface staining and red nuclei) in a lymphoid follicle of the large intestine.

 

 

 

Marianne Quiding-Järbrink research group 

Contact Information | List of Publications

 

Lymphocyte recirculation through the body is not a random process, but lymphocytes migrate through selected tissues depending on their activation and maturation stage, subtype, and tissue of origin. This tissue-specific migration is dependent on selected adhesion molecules on lymphocytes as well as endothelial cells, and production of tissue-specific chemokines and expression of their respective receptors on circulating lymphocytes.

The aim of our project is to characterize the mechanisms of lymphocyte recruitment to mucosal tissues, both during steady state and in gastrointestinal tumors. We use tissue resection material from cancer patients and blood from volunteers, and also use a mouse model of colon cancer. We have also established an in vitro system to examine transendothelial migration of lymphocytes. More specifically, we are studying the expression of endothelial adhesion molecules and chemokines in unaffected and tumor tissues, and how these shape the repertoire of tumor-infiltrating lymphocytes. We also examine the ability of tumor cells to directly influence the function of endothelial cells and their expression of homing-related molecules. Finally, the ability of regulatory T cells to influence lymphocyte recruitment in cancer patients is determined. In a second line of studies, we are investigating the effector functions of different types of T cells in gastrointestinal tumors, and how these are influenced by the tumor microenvironment and the presence of regulatory T cells. The knowledge gained from these studies will be used to improve current strategies for mucosal immunization and immunotherapy against gastrointestinal tumors.

 

Selected publications 

 

Marianne Quiding-Järbrink

Contact Information

List of Publications

Group members

Marianne Quiding-Järbrink, PhD, professor, group leader
Patrik Sundström, PhD; post-doc
Paulina Akeus, MSc, PhD student
Filip Ahlmanner, MD, PhD student
Malin Sundquist, MD, PhD
Jenny Eklöf, PhD, amanuens

Sidansvarig: Dan Baeckström|Sidan uppdaterades: 2016-11-07
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