Jikui Guan

ALK signaling primes the DNA damage response sensitizing ALK-driven neuroblastoma to therapeutic ATR

Marcus Borenäs, Ganesh Umapathy, Dan E. Lind, Wei-Yun Lai, Jikui Guan, Joel Johansson, Eva Jennische, Alexander Schmidt, Yeshwant Kurhe, Jonatan L. Gabre, Agata Aniszewska, Anneli Strömberg, Mats Bemark, Michael N. Hall, Jimmy Van den Eynden, Bengt Hallberg, Ruth H. Palmer
Proceedings of the National Academy of Sciences of the United States of America - 2024

ALK F1174S mutation impairs ALK kinase activity in EML4-ALK variant 1 and sensitizes EML4-ALK variant 3 to

crizotinib

Jikui Guan, Tzu-Po Chuang, Anders Vikstrom, Ruth H. Palmer, Bengt Hallberg
FRONTIERS IN ONCOLOGY - 2024

IGF1R Contributes to Cell Proliferation in ALK-Mutated Neuroblastoma with Preference for Activating the PI3K-AKT Signaling

Pathway.

Jikui Guan, Marcus Borenäs, Junfeng Xiong, Wei-Yun Lai, Ruth H. Palmer, Bengt Hallberg
Cancers - 2023

Sustained Response to Entrectinib in an Infant With a Germline ALKAL2 Variant and Refractory Metastatic Neuroblastoma With Chromosomal 2p Gain and Anaplastic Lymphoma Kinase and Tropomyosin Receptor Kinase

Activation

D. Treis, Ganesh Umapathy, Susanne Fransson, Jikui Guan, Patricia Mendoza-García, Joachim T. Siaw, S. Wessman, L. G. Murkes, J. J. E. Stenman, Anna Djos, L. H. M. Elfman, J. I. Johnsen, Bengt Hallberg, Ruth H. Palmer, Tommy Martinsson, P. Kogner
JCO Precision Oncology - 2022

Chromosome imbalances in neuroblastoma—recent molecular insight into chromosome 1p-deletion, 2p-gain, and 11q-deletion identifies new friends and foes for the

future

Jikui Guan, Bengt Hallberg, Ruth H. Palmer
Cancers - 2021

ALK ligand ALKAL2 potentiates MYCN-driven neuroblastoma in the absence of ALK

mutation.

Marcus Borenäs, Ganesh Umapathy, Wei-Yun Lai, Dan E. Lind, Barbara Witek, Jikui Guan, Patricia Mendoza-García, Tafheem Masudi, Arne Claeys, Tzu-Po Chuang, Abeer El Wakil, Badrul Arefin, Susanne Fransson, Jan Koster, Mathias Johansson, Jennie Gaarder, Jimmy Van den Eynden, Bengt Hallberg, Ruth H. Palmer
The EMBO journal - 2021

Mapping the Phospho-dependent ALK Interactome to Identify Novel Components in ALK

Signaling

F. Aboualizadeh, Z. Yao, Jikui Guan, L. Drecun, S. Pathmanathan, J. Snider, Ganesh Umapathy, M. Kotlyar, I. Jurisica, Ruth H. Palmer, I. Stagljar
Journal of Molecular Biology - 2021

BioID-Screening Identifies PEAK1 and SHP2 as Components of the ALK Proximitome in Neuroblastoma

Cells

Ezgi Uçkun, Joachim T. Siaw, Jikui Guan, Vimala Anthonydhason, Johannes Fuchs, Georg Wolfstetter, Bengt Hallberg, Ruth H. Palmer
Journal of Molecular Biology - 2021

Extracellular domain shedding of the ALK receptor mediates neuroblastoma cell

migration

H. Huang, A. Gont, L. Kee, R. Dries, K. Pfeifer, B. Sharma, D. N. Debruyne, M. Harlow, S. Sengupta, Jikui Guan, C. M. Yeung, W. C. Wang, Bengt Hallberg, Ruth H. Palmer, M. S. Irwin, R. E. George
Cell Reports - 2021

Loss of RET Promotes Mesenchymal Identity in Neuroblastoma

Cells

Joachim T. Siaw, Jonatan L. Gabre, Ezgi Uçkun, M. Vigny, W. C. Zhang, J. Van den Eynden, Bengt Hallberg, Ruth H. Palmer, Jikui Guan
Cancers - 2021

13P - Phosphoproteome and gene expression profiling of ALK inhibition in neuroblastoma cell lines reveals conserved oncogenic

pathways

Ganesh Umapathy, Jimmy Van den Eynden, Diana Lizeth Cervantes-Madrid, Joanna Szydzik, Jikui Guan, Ruth H. Palmer, Bengt Hallberg
Annals of oncology : official journal of the European Society for Medical Oncology. Vol. 30, Suppl. 1, p. i6 - 2019

Clinical response of the novel activating ALK-I1171T mutation in neuroblastoma to the ALK inhibitor

ceritinib.

Jikui Guan, Susanne Fransson, Joachim T. Siaw, Diana Treis, Jimmy Van den Eynden, Damini Chand, Ganesh Umapathy, Kristina Ruuth, Alia Shamikh, Hans Jacobsson, Lena Gordon, Par-Johan Svensson, Magnus Hansson, Tommy Martinsson, Per Kogner, Ruth H. Palmer, Bengt Hallberg
Cold Spring Harbor molecular case studies - 2018

Phosphoproteome and gene expression profiling of ALK inhibition in neuroblastoma cell lines reveals conserved oncogenic

pathways.

Jimmy Van den Eynden, Ganesh Umapathy, Arghavan Ashouri, Diana Lizeth Cervantes-Madrid, Joanna Szydzik, Kristina Ruuth, Jan Koster, Erik Larsson, Jikui Guan, Ruth H. Palmer, Bengt Hallberg
Science signaling - 2018

ALKALs are in vivo ligands for ALK family receptor tyrosine kinases in the neural crest and derived

cells.

Andrey Fadeev, Patricia Mendoza-García, Uwe Irion, Jikui Guan, Kathrin Pfeifer, Stephanie Wiessner, Fabrizio Serluca, Ajeet Pratap Singh, Christiane Nüsslein-Volhard, Ruth H. Palmer
Proceedings of the National Academy of Sciences of the United States of America - 2018

Novel Mechanisms of ALK Activation Revealed by Analysis of the Y1278S Neuroblastoma

Mutation.

Jikui Guan, Yasuo Yamazaki, Damini Chand, Jesper R van Dijk, Kristina Ruuth, Ruth H. Palmer, Bengt Hallberg
Cancers - 2017

MEK inhibitor trametinib does not prevent the growth of anaplastic lymphoma kinase (ALK)-addicted

neuroblastomas.

Ganesh Umapathy, Jikui Guan, Dan Gustafsson, Niloufar Javanmardi, Diana Lizeth Cervantes-Madrid, Anna Djos, Tommy Martinsson, Ruth H. Palmer, Bengt Hallberg
Science signaling - 2017

Anaplastic lymphoma kinase L1198F and G1201E mutations identified in anaplastic thyroid cancer patients are not

ligand-independent.

Jikui Guan, Georg Wolfstetter, Joachim T. Siaw, Damini Chand, Fredrik Hugosson, Ruth H. Palmer, Bengt Hallberg
Oncotarget - 2017

The ALK inhibitor PF-06463922 is effective as a single agent in neuroblastoma driven by expression of ALK and

MYCN

Jikui Guan, E. R. Tucker, Haiying Wang, Damini Chand, L. S. Danielson, Kristina Ruuth, Abeer El Wakil, Barbara Witek, Y. Jamin, Ganesh Umapathy, S. P. Robinson, T. W. Johnson, T. Smeal, Tommy Martinsson, L. Chesler, Ruth H. Palmer, Bengt Hallberg
DMM Disease Models and Mechanisms - 2016

Brigatinib, an anaplastic lymphoma kinase inhibitor, abrogates activity and growth in ALK-positive neuroblastoma cells, Drosophila and

mice

Joachim T. Siaw, Haiying Wang, Kathrin Pfeifer, V. M. Rivera, Jikui Guan, Ruth H. Palmer, Bengt Hallberg
Oncotarget - 2016

FAM150A and FAM150B are activating ligands for Anaplastic Lymphoma

Kinase.

Jikui Guan, Ganesh Umapathy, Yasuo Yamazaki, Georg Wolfstetter, Patricia Mendoza, Kathrin Pfeifer, Ateequrrahman Mohammed, Fredrik Hugosson, Hongbing Zhang, Amy W Hsu, Robert Halenbeck, Bengt Hallberg, Ruth H. Palmer
eLife - 2015

Jikui Guan

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