Liisa Arike

Muc2-dependent microbial colonization of the jejunal mucus layer is diet sensitive and confers local resistance to enteric pathogen

infection

George M. H. Birchenough, Björn O. Schröder, Sinan Sharba, Liisa Arike, Christian V Recktenwald, F. Puertolas-Balint, Mahadevan Subramani, Karl Hansson, B. Yilmaz, Sara K. Lindén, Fredrik Bäckhed, Gunnar C. Hansson
Cell Reports - 2023

Trans-Golgi protein TVP23B regulates host-microbe interactions via Paneth cell homeostasis and Goblet cell

glycosylation

R. Song, W. McAlpine, A. M. Fond, E. Nair-Gill, J. H. Choi, E. E. L. Nystrom, Liisa Arike, S. Field, X. H. Li, J. A. SoRelle, J. J. Moresco, E. M. Y. Moresco, J. R. Yates, P. Azadi, J. Ni, George M. H. Birchenough, B. Beutler, E. E. Turer
Nature Communications - 2023

Transglutaminase 3 crosslinks the secreted gel-forming mucus component Mucin-2 and stabilizes the colonic mucus

layer

Jack D. A. Sharpen, Brendan Dolan, Elisabeth E. L. Nyström, George M. H. Birchenough, Liisa Arike, Beatriz Martinez Abad, Malin E V Johansson, Gunnar C. Hansson, Christian V Recktenwald
Nature Communications - 2022

An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier

function

Elisabeth E. L. Nyström, Beatriz Martinez Abad, Liisa Arike, George M. H. Birchenough, E. B. Nonnecke, P. A. Castillo, Frida Svensson, C. L. Bevins, Gunnar C. Hansson, Malin E V Johansson
Science - 2021

Metaproteomics Analysis of Host–Microbiota

Interfaces

Sjoerd van der Post, Liisa Arike
Shotgun Proteomics - 2021

IL-22 promotes the formation of a MUC17 glycocalyx barrier in the postnatal small intestine during

weaning

Elena Layunta, Sofia Jäverfelt, Brendan Dolan, Liisa Arike, Thaher Pelaseyed
Cell Reports - 2021

Protein Turnover in Epithelial Cells and Mucus along the Gastrointestinal Tract Is Coordinated by the Spatial Location and

Microbiota

Liisa Arike, A. Seiman, Sjoerd van der Post, Ana María Rodríguez-Piñeiro, Anna Ermund, André Schütte, Fredrik Bäckhed, Malin E V Johansson, Gunnar C. Hansson
Cell Reports - 2020

Identifying transglutaminase reaction products via mass spectrometry as exemplified by the MUC2 mucin - Pitfalls and

traps

Liisa Arike, Gunnar C. Hansson, Christian V Recktenwald
Analytical Biochemistry - 2020

The human transmembrane mucin MUC17 responds to TNF alpha by increased presentation at the plasma

membrane

Hannah Schneider, Evelin Berger, Brendan Dolan, Beatriz Martinez Abad, Liisa Arike, Thaher Pelaseyed, Gunnar C. Hansson
Biochemical Journal - 2019

Normal calcium-activated anion secretion in a mouse selectively lacking TMEM16A in intestinal

epithelium

Génesis Vega, Anita Guequén, Malin E V Johansson, Liisa Arike, Beatriz Martinez Abad, Elisabeth E. L. Nyström, Paolo Scudieri, Nicoletta Pedemonte, Pamela Millar-Büchner, Amber R. Philp, Luis J. Galietta, Gunnar C. Hansson, Carlos A. Flores
Frontiers in Physiology - 2019

Potential roles of gut microbiome and metabolites in modulating ALS in

mice

E. Blacher, S. Bashiardes, H. Shapiro, D. Rothschild, U. Mor, M. Dori-Bachash, C. Kleimeyer, C. Moresi, Y. Harnik, M. Zur, M. Zabari, R. B. Z. Brik, D. Kviatcovsky, N. Zmora, Y. Cohen, N. Bar, I. Levi, N. Amar, T. Mehlman, A. Brandis, I. Biton, Y. Kuperman, M. Tsoory, L. Alfahel, A. Harmelin, M. Schwartz, A. Israelson, Liisa Arike, Malin E V Johansson, Gunnar C. Hansson, M. Gotkine, E. Segal, E. Elinav
Nature - 2019

Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis

pathogenesis

Sjoerd van der Post, Karolina S. Jabbar, George M. H. Birchenough, Liisa Arike, Noreen Akhtar, Henrik Sjövall, Malin E V Johansson, Gunnar C. Hansson
Gut - 2019

Calcium-activated chloride channel regulator 1 (CLCA1) forms non-covalent oligomers in colonic mucus and has mucin 2-processing

properties

Elisabeth E. L. Nyström, Liisa Arike, Erik Ehrencrona, Gunnar C. Hansson, Malin E V Johansson
Journal of Biological Chemistry - 2019

Highly Accurate Identification of Cystic Precursor Lesions of Pancreatic Cancer Through Targeted Mass Spectrometry: A Phase IIc Diagnostic

Study

Karolina S. Jabbar, Liisa Arike, C. S. Verbeke, R. Sadik, Gunnar C. Hansson
Clinical Oncology - 2018

Attached stratified mucus separates bacteria from the epithelial cells in COPD

lungs

Dalia Fakih, Liisa Arike, Ana María Rodríguez-Piñeiro, Beatriz Martinez Abad, Elin Skansebo, S. Jackson, J. Root, D. Singh, Cristopher McCrae, C. M. Evans, A. Astrand, Anna Ermund, Gunnar C. Hansson
Jci Insight - 2018

Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus

Deterioration

Björn O. Schröder, George M. H. Birchenough, Marcus Ståhlman, Liisa Arike, Malin E V Johansson, Gunnar C. Hansson, Fredrik Bäckhed
Cell Host & Microbe - 2018

Calcium-activated Chloride Channel Regulator 1 (CLCA1) Controls Mucus Expansion in Colon by Proteolytic

Activity

Elisabeth E. L. Nyström, George M. H. Birchenough, Sjoerd van der Post, Liisa Arike, A. D. Gruber, Gunnar C. Hansson, Malin E V Johansson
Ebiomedicine - 2018

Intestinal Muc2 mucin O-glycosylation is affected by microbiota and regulated by differential expression of

glycosyltranferases

Liisa Arike, Jessica Holmén Larsson, Gunnar C. Hansson
Glycobiology - 2017

The Densely O-Glycosylated MUC2 Mucin Protects the Intestine and Provides Food for the Commensal

Bacteria.

Liisa Arike, Gunnar C. Hansson
Journal of molecular biology - 2016

Normalization of Host Intestinal Mucus Layers Requires Long-Term Microbial

Colonization

Malin E V Johansson, Hedvig E Jakobsson, Jessica Holmén Larsson, André Schütte, Anna Ermund, Ana María Rodríguez-Piñeiro, Liisa Arike, Catharina Wising, Frida Svensson, Fredrik Bäckhed, Gunnar C. Hansson
Cell Host & Microbe - 2015

The Goblet Cell Protein Clca1 (Alias mClca3 or Gob-5) Is Not Required for Intestinal Mucus Synthesis, Structure and Barrier Function in Naive or DSS-Challenged

Mice

N. A. Erickson, Elisabeth E. L. Nyström, L. Mundhenk, Liisa Arike, R. Glauben, M. M. Heimesaat, A. Fischer, S. Bereswill, George M. H. Birchenough, A. D. Gruber, Malin E V Johansson
Plos One - 2015

Liisa Arike

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