Anna Ermund

Proteome of airway surface liquid and mucus in newborn wildtype and cystic fibrosis

Ana Rodriguez-Piñeiro, Florian Jaudas, Nikolai Klymiuk, Andrea Bähr, Gunnar C. Hansson, Anna Ermund
Respiratory Research - 2023

Goblet cell interactions reorient bundled mucus strands for efficient airway

clearance

Meike F. Bos, Anna Ermund, Gunnar C. Hansson, Joost de Graaf
PNAS Nexus - 2023

Clearance of small intestinal crypts involves goblet cell mucus secretion by intracellular granule rupture and enterocyte ion

transport

Brendan Dolan, Anna Ermund, Beatriz Martinez Abad, M Johansson, Gunnar C. Hansson
Science Signaling - 2022

Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory

Granules.

Oanh N Hoang, Anna Ermund, Ana M Jaramillo, Dalia Fakih, Cory B French, Jose R Flores, Harry Karmouty-Quintana, Jesper Magnusson, Giorgio Fois, Michael Fauler, Manfred Frick, Peter Braubach, Joshua B Hales, Richard C Kurten, Reynold Panettieri, Leoncio Vergara, Camille Ehre, Roberto Adachi, Michael J Tuvim, Gunnar C. Hansson, Burton F Dickey
American journal of respiratory and critical care medicine - 2022

Mucus threads from surface goblet cells clear particles from the

airways

Anna Ermund, Lauren N Meiss, Brendan Dolan, F. Jaudas, Lars Ewaldsson, A. Bahr, N. Klymiuk, Gunnar C. Hansson
Respiratory Research - 2021

New generation ENaC inhibitors detach cystic fibrosis airway mucus bundles via sodium/hydrogen exchanger

inhibition

Melania Giorgetti, N. Klymiuk, A. Bahr, M. Hemmerling, L. Jinton, R. Tarran, A. Malmgren, A. Astrand, Gunnar C. Hansson, Anna Ermund
European Journal of Pharmacology - 2021

Association between Brachyspira and irritable bowel syndrome with

diarrhoea

Karolina S. Jabbar, Brendan Dolan, Lisbeth Eklund, Catharina Wising, Anna Ermund, Åsa Johansson, Hans Törnblom, Magnus Simrén, Gunnar C. Hansson
Gut - 2021

Normal murine respiratory tract has its mucus concentrated in clouds based on the Muc5b

mucin

Dalia Fakih, Ana Rodriguez-Piñeiro, Sergio Trillo-Muyo, C. M. Evans, Anna Ermund, Gunnar C. Hansson
American Journal of Physiology-Lung Cellular and Molecular Physiology - 2020

Protein Turnover in Epithelial Cells and Mucus along the Gastrointestinal Tract Is Coordinated by the Spatial Location and

Microbiota

Liisa Arike, A. Seiman, Sjoerd van der Post, Ana María Rodríguez-Piñeiro, Anna Ermund, André Schütte, Fredrik Bäckhed, Malin E V Johansson, Gunnar C. Hansson
Cell Reports - 2020

Extracellular ATP activates store-operated Ca2+ entry in white adipocytes: functional evidence for STIM1 and

ORAI1

Michael El Hachmane, Anna Ermund, Cecilia Brännmark, Charlotta S Olofsson
Biochemical Journal - 2018

Attached stratified mucus separates bacteria from the epithelial cells in COPD

lungs

Dalia Fakih, Liisa Arike, Ana María Rodríguez-Piñeiro, Beatriz Martinez Abad, Elin Skansebo, S. Jackson, J. Root, D. Singh, Cristopher McCrae, C. M. Evans, A. Astrand, Anna Ermund, Gunnar C. Hansson
Jci Insight - 2018

Granule-stored MUC5B mucins are packed by the non-covalent formation of N-terminal head-to-head

tetramers

Sergio Trillo-Muyo, Harriet E. Nilsson, Christian V Recktenwald, Anna Ermund, C. Ridley, Lauren N Meiss, A. Bahr, N. Klymiuk, Jeffrey J. Wine, P. J. B. Koeck, D. J. Thornton, H. Hebert, Gunnar C. Hansson
Journal of Biological Chemistry - 2018

Assembly, Release, and Transport of Airway Mucins in Pigs and

Humans

Anna Ermund, Sergio Trillo-Muyo, Gunnar C. Hansson
Annals of the American Thoracic Society - 2018

The mucus bundles responsible for airway cleaning are retained in cystic fibrosis and by cholinergic

stimulation

Anna Ermund, Lauren N Meiss, Brendan Dolan, A. Bahr, N. Klymiuk, Gunnar C. Hansson
European Respiratory Journal - 2018

Progress in understanding mucus abnormalities in cystic fibrosis

airways

J. J. Wine, Gunnar C. Hansson, P. Konig, N. S. Joo, Anna Ermund, M. Pieper
Journal of Cystic Fibrosis - 2018

Mucus Detachment by Host Metalloprotease Meprin beta Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease

RgpB

R. Wichert, Anna Ermund, S. Schmidt, M. Schweinlin, M. Ksiazek, P. Arnold, K. Knittler, F. Wilkens, B. Potempa, B. Rabe, M. Stirnberg, R. Lucius, J. W. Bartsch, S. Nikolaus, M. Falk-Paulsen, P. Rosenstiel, M. Metzger, S. Rose-John, J. Potempa, Gunnar C. Hansson, P. J. Dempsey, C. Becker-Pauly
Cell Reports - 2017

OligoG CF-5/20 normalizes cystic fibrosis mucus by chelating

calcium.

Anna Ermund, Christian V Recktenwald, Gudmund Skjåk-Braek, Lauren N Meiss, Edvar Onsøyen, Philip D Rye, Arne Dessen, Astrid Hilde Myrset, Gunnar C. Hansson
Clinical and experimental pharmacology & physiology - 2017

The normal trachea is cleaned by MUC5B mucin bundles from the submucosal glands coated with the MUC5AC

mucin

Anna Ermund, Lauren N Meiss, Ana María Rodríguez-Piñeiro, A. Bahr, Harriet E. Nilsson, Sergio Trillo-Muyo, C. Ridley, D. J. Thornton, J. J. Wine, H. Hebert, N. Klymiuk, Gunnar C. Hansson
Biochemical and Biophysical Research Communications - BBRC - 2017

Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein

ZG16.

Joakim H. Bergström, George M. H. Birchenough, Gergely Katona, Björn O. Schröder, André Schütte, Anna Ermund, Malin E V Johansson, Gunnar C. Hansson
Proceedings of the National Academy of Sciences of the United States of America - 2016

The composition of the gut microbiota shapes the colon mucus

barrier.

Hedvig E Jakobsson, Ana María Rodríguez-Piñeiro, André Schütte, Anna Ermund, Preben Boysen, Mats Bemark, Felix Sommer, Fredrik Bäckhed, Gunnar C. Hansson, Malin E V Johansson
EMBO reports - 2015

Normalization of Host Intestinal Mucus Layers Requires Long-Term Microbial

Colonization

Malin E V Johansson, Hedvig E Jakobsson, Jessica Holmén Larsson, André Schütte, Anna Ermund, Ana María Rodríguez-Piñeiro, Liisa Arike, Catharina Wising, Frida Svensson, Fredrik Bäckhed, Gunnar C. Hansson
Cell Host & Microbe - 2015

Hyper-osmolarity and calcium chelation: Effects on cystic fibrosis

mucus

Anna Ermund, Lauren N Meiss, Jenny K Gustafsson, Gunnar C. Hansson
European Journal of Pharmacology - 2015

Hypertonic saline releases the attached small intestinal cystic fibrosis

mucus.

Anna Ermund, Lauren N Meiss, Bob J Scholte, Gunnar C. Hansson
Clinical and experimental pharmacology & physiology - 2015

The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune

system

Thaher Pelaseyed, Joakim H. Bergström, Jenny K Gustafsson, Anna Ermund, George M. H. Birchenough, André Schütte, Sjoerd van der Post, Frida Svensson, Ana María Rodríguez-Piñeiro, Elisabeth E. L. Nyström, Catharina Wising, Malin E V Johansson, Gunnar C. Hansson
Immunological Reviews - 2014

Microbial-induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal

mucus

André Schütte, Anna Ermund, C. Becker-Pauly, Malin E V Johansson, Ana María Rodríguez-Piñeiro, Fredrik Bäckhed, S.C. Müller, D. Lottaz, J.S. Bond, Gunnar C. Hansson
Proceedings of the National Academy of Sciences of the United States of America - 2014

Carbachol-induced MUC17 endocytosis is concomitant with NHE3 internalization and CFTR membrane recruitment in

enterocytes.

Thaher Pelaseyed, Jenny K Gustafsson, Ida J Gustafsson, Anna Ermund, Gunnar C. Hansson
American journal of physiology. Cell physiology - 2013

Studies of mucus in mouse stomach, small intestine, and colon. II. Gastrointestinal mucus proteome reveals Muc2 and Muc5ac accompanied by a set of core

proteins.

Ana María Rodríguez-Piñeiro, Joakim H. Bergström, Anna Ermund, Jenny K Gustafsson, André Schütte, Malin E V Johansson, Gunnar C. Hansson
American journal of physiology. Gastrointestinal and liver physiology - 2013

Studies of mucus in mouse stomach, small intestine, and colon. I. Gastrointestinal mucus layers have different properties depending on location as well as over the Peyer's

patches.

Anna Ermund, André Schütte, Malin E V Johansson, Jenny K Gustafsson, Gunnar C. Hansson
American journal of physiology. Gastrointestinal and liver physiology - 2013

Mucus properties and goblet cell quantification in mouse, rat and human ileal Peyer's

patches.

Anna Ermund, Jenny K Gustafsson, Gunnar C. Hansson, Asa V Keita
PloS one - 2013

An ex vivo method for studying mucus formation, properties and thickness in human colonic biopsies and mouse small and large intestinal

explants.

Jenny K Gustafsson, Anna Ermund, Malin E V Johansson, André Schütte, Gunnar C. Hansson, Henrik Sjövall
American journal of physiology. Gastrointestinal and liver physiology - 2012

Perspectives on mucus properties and formation--lessons from the biochemical

world.

Daniel Ambort, Malin E V Johansson, Jenny K Gustafsson, Anna Ermund, Gunnar C. Hansson
Cold Spring Harbor perspectives in medicine - 2012

Calcium and pH-dependent packing and release of the gel-forming MUC2

mucin.

Daniel Ambort, Malin E V Johansson, Jenny K Gustafsson, Harriet E Nilsson, Anna Ermund, Bengt R Johansson, Philip J B Koeck, Hans Hebert, Gunnar C. Hansson
Proceedings of the National Academy of Sciences of the United States of America - 2012

Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus

phenotype.

Jenny K Gustafsson, Anna Ermund, Daniel Ambort, Malin E V Johansson, Harriet E Nilsson, Kaisa Thorell, Hans Hebert, Henrik Sjövall, Gunnar C. Hansson
The Journal of experimental medicine - 2012

Composition and functional role of the mucus layers in the

intestine.

Malin E V Johansson, Daniel Ambort, Thaher Pelaseyed, André Schütte, Jenny K Gustafsson, Anna Ermund, Durai B Subramani, Jessica Holmén Larsson, Kristina A Thomsson, Joakim H. Bergström, Sjoerd van der Post, Ana María Rodríguez-Piñeiro, Henrik Sjövall, Malin Bäckström, Gunnar C. Hansson
Cellular and Molecular Life Sciences - 2011

Anna Ermund

Forskare

Publikationer