- Hem
- Om universitetet
- Hitta person
- Claes Gustafsson
Claes Gustafsson
Professor
Avd för medicinsk kemi ochViceprefekt
Institutionen förOm Claes Gustafsson
-
Mechanisms and regulation of human mitochondrial
transcription
B. G. Tan, Claes M Gustafsson, Maria Falkenberg
Nature Reviews Molecular Cell Biology - 2023 -
TEFM variants impair mitochondrial transcription causing childhood-onset neurological
disease
L. Van Haute, E. O'Connor, Hector Diaz-Maldonado, B. Munro, K. Polavarapu, D. H. Hock, G. Arunachal, A. Athanasiou-Fragkouli, M. Bardhan, M. Barth, D. Bonneau, N. Brunetti-Pierri, G. Cappuccio, N. J. Caruana, N. Dominik, H. Goel, G. Helman, H. Houlden, G. Lenaers, K. Mention, D. Murphy, B. Nandeesh, C. Olimpio, C. A. Powell, V. Preethish-Kumar, V. Procaccio, R. Rius, P. Rebelo-Guiomar, C. Simons, S. Vengalil, M. S. Zaki, A. Ziegler, D. R. Thorburn, D. A. Stroud, R. Maroofian, J. Christodoulou, Claes M Gustafsson, A. Nalini, H. Lochmuller, M. Minczuk, R. Horvath
Nature Communications - 2023 -
Pathological variants in TOP3A cause distinct disorders of mitochondrial and nuclear genome
stability
Direnis Erdinc, A. Rodriguez-Luis, M. R. Fassad, S. Mackenzie, C. M. Watson, Sebastian Valenzuela, Xie Xie, K. E. Menger, K. Sergeant, K. Craig, S. Hopton, G. Falkous, J. Poulton, H. Garcia-Moreno, P. Giunti, C. A. D. Aschoff, J. A. M. Saute, A. J. Kirby, C. Toro, L. Wolfe, D. Novacic, L. Greenbaum, A. Eliyahu, O. Barel, Y. Anikster, R. McFarland, G. S. Gorman, A. M. Schaefer, Claes M Gustafsson, R. W. Taylor, Maria Falkenberg, T. J. Nicholls
Embo Molecular Medicine - 2023 -
Lsm7 phase-separated condensates trigger stress granule
formation
Michelle Lindström, Lihua Chen, Shan Jiang, Dan Zhang, Yuan Gao, J. Zheng, Xinxin Hao, Xiaoxue Yang, Arpitha Kabbinale, Johannes Thoma, Lisa Metzger, D. Y. Zhang, Xuefeng Zhu, H. S. Liu, Claes M Gustafsson, Björn Marcus Burmann, J. Winderickx, Per Sunnerhagen, Beidong Liu
Nature Communications - 2022 -
Article Non-coding 7S RNA inhibits transcription via mitochondrial RNA polymerase
dimerization
Xuefeng Zhu, Xie Xie, H. Das, Benedict Tan, Yonghong Shi, Ali Al-Behadili, Bradley Peter, E. Motori, Sebastian Valenzuela, Viktor Posse, Claes M Gustafsson, B. M. Hallberg, Maria Falkenberg
Cell - 2022 -
Ribonucleotides embedded in template DNA impair mitochondrial RNA polymerase
progression
Meenakshi Singh, Viktor Posse, Bradley Peter, Maria Falkenberg, Claes M Gustafsson
Nucleic Acids Research - 2022 -
The human mitochondrial genome contains a second light strand
promoter
Benedict Tan, C. D. Mutti, Yonghong Shi, Xie Xie, Xuefeng Zhu, P. Silva-Pinheiro, K. E. Menger, Hector Diaz-Maldonado, W. Wei, T. J. Nicholls, P. F. Chinnery, M. Minczuk, Maria Falkenberg, Claes M Gustafsson
Molecular Cell - 2022 -
The mitochondrial single-stranded DNA binding protein is essential for initiation of mtDNA
replication
M. Jiang, Xie Xie, Xuefeng Zhu, S. Jiang, D. Milenkovic, J. Misic, Yonghong Shi, N. Tandukar, X. Li, I. Atanassov, Louise Jenninger, Emily Hoberg, S. Albarran-Gutierrez, Zsolt Szilagyi, Bertil Macao, S. J. Siira, V. Carelli, J. D. Griffith, Claes M Gustafsson, T. J. Nicholls, A. Filipovska, N. G. Larsson, Maria Falkenberg
Science Advances - 2021 -
POLRMT mutations impair mitochondrial transcription causing neurological
disease
M. Olahova, Bradley Peter, Zsolt Szilagyi, Hector Diaz-Maldonado, Meenakshi Singh, E. W. Sommerville, E. L. Blakely, J. J. Collier, Emily Hoberg, V. Stranecky, H. Hartmannova, A. J. Bleyer, K. L. McBride, S. A. Bowden, Z. Korandova, A. Pecinova, H. H. Ropers, K. Kahrizi, H. Najmabadi, M. A. Tarnopolsky, L. I. Brady, K. N. Weaver, C. E. Prada, K. Ounap, M. H. Wojcik, S. Pajusalu, S. B. Syeda, L. Pais, E. A. Estrella, C. C. Bruels, L. M. Kunkel, P. B. Kang, P. E. Bonnen, T. Mracek, S. Kmoch, G. S. Gorman, Maria Falkenberg, Claes M Gustafsson, R. W. Taylor
Nature Communications - 2021 -
Mammalian mitochondrial DNA replication and mechanisms of deletion
formation
Maria Falkenberg, Claes M Gustafsson
Critical Reviews in Biochemistry and Molecular Biology - 2020 -
Absolute yeast mitochondrial proteome quantification reveals trade-off between biosynthesis and energy generation during diauxic
shift
Francesca Di Bartolomeo, C. Malina, K. Campbell, M. Mormino, Johannes Fuchs, Egor Vorontsov, Claes M Gustafsson, J. Nielsen
Proceedings of the National Academy of Sciences of the United States of America - 2020 -
Small-molecule inhibitors of human mitochondrial DNA
transcription
N. A. Bonekamp, Bradley Peter, H. S. Hillen, A. Felser, T. Bergbrede, A. Choidas, M. Horn, A. Unger, R. Di Lucrezia, I. Atanassov, X. P. Li, U. Koch, S. Menninger, J. Boros, P. Habenberger, P. Giavalisco, P. Cramer, M. S. Denzel, P. Nussbaumer, B. Klebl, Maria Falkenberg, Claes M Gustafsson, N. G. Larsson
Nature - 2020 -
Accurate mapping of mitochondrial DNA deletions and duplications using deep
sequencing
Swaraj Basu, Xie Xie, Jay (Jennifer) Uhler, Carola Oldfors Hedberg, D. Milenkovic, O. R. Baris, S. Kimoloi, S. Matic, J. B. Stewart, N. G. Larsson, R. J. Wiesner, Anders Oldfors, Claes M Gustafsson, Maria Falkenberg, Erik Larsson
PLoS Genetics - 2020 -
Yeast mismatch repair components are required for stable inheritance of gene
silencing
Qian Liu, Xuefeng Zhu, Michelle Lindström, Yonghong Shi, Ju Zheng, Xinxin Hao, Claes M Gustafsson, Beidong Liu
Plos Genetics - 2020 -
Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian
Mitochondria
Thomas J. Nicholls, H. Spahr, S. Jiang, S. J. Siira, C. Koolmeister, S. Sharma, J. H. K. Kauppila, M. Jiang, V. Kaever, O. Rackham, A. Chabes, Maria Falkenberg, A. Filipovska, N. G. Larsson, Claes M Gustafsson
Molecular Cell - 2019 -
Copy-choice recombination during mitochondrial L-strand synthesis causes DNA
deletions
Örjan Persson, Yazh Muthukumar, Swaraj Basu, Louise Jenninger, Jay (Jennifer) Uhler, Anna-Karin Berglund, R. McFarland, R. W. Taylor, Claes M Gustafsson, Erik Larsson, Maria Falkenberg
Nature Communications - 2019 -
RNase H1 directs origin-specific initiation of DNA replication in human
mitochondria
Viktor Posse, Ali Al-Behadili, Jay (Jennifer) Uhler, Anders R Clausen, A. Reyes, M. Zeviani, Maria Falkenberg, Claes M Gustafsson
Plos Genetics - 2019 -
Separating and Segregating the Human Mitochondrial
Genome
Thomas J. Nicholls, Claes M Gustafsson
Trends in Biochemical Sciences - 2018 -
Topoisomerase 3α Is Required for Decatenation and Segregation of Human
mtDNA
Thomas J. Nicholls, C. A. Nadalutti, E. Motori, E. W. Sommerville, G. S. Gorman, Swaraj Basu, Emily Hoberg, D. M. Turnbull, P. F. Chinnery, N. G. Larsson, Erik Larsson, Maria Falkenberg, R. W. Taylor, J. D. Griffith, Claes M Gustafsson
Molecular Cell - 2018 -
An Adaptable High-Throughput Technology Enabling the Identification of Specific Transcription
Modulators
T. Bergbrede, Emily Hoberg, N. G. Larsson, Maria Falkenberg, Claes M Gustafsson
Slas Discovery - 2017 -
Human Mitochondrial Transcription Factor B2 Is Required for Promoter Melting during Initiation of
Transcription
Viktor Posse, Claes M Gustafsson
Journal of Biological Chemistry - 2017 -
Cyclin C influences the timing of mitosis in fission
yeast.
Gabor Banyai, Zsolt Szilagyi, Vera Baraznenok, Olga Khorosjutina, Claes M Gustafsson
Molecular biology of the cell - 2017 -
Mutations in mitochondrial DNA causing tubulointerstitial kidney
disease
T. M. Connor, S. Hoer, A. Mallett, D. P. Gale, A. Gomez-Duran, Viktor Posse, R. Antrobus, P. Moreno, M. Sciacovelli, C. Frezza, J. Duff, N. S. Sheerin, J. A. Sayer, M. Ashcroft, M. S. Wiesener, G. Hudson, Claes M Gustafsson, P. F. Chinnery, P. H. Maxwell
Plos Genetics - 2017 -
Nucleotide pools dictate the identity and frequency of ribonucleotide incorporation in mitochondrial
DNA.
Anna-Karin Berglund, Clara Navarrete, Martin K M Engqvist, Emily Hoberg, Zsolt Szilagyi, Robert W Taylor, Claes M Gustafsson, Maria Falkenberg, Anders R Clausen
PLoS genetics - 2017 -
POLRMT regulates the switch between replication primer formation and gene expression of mammalian
mtDNA
I. Kuhl, M. Miranda, Viktor Posse, D. Milenkovic, A. Mourier, S. J. Siira, N. A. Bonekamp, U. Neumann, A. Filipovska, P. L. Polosa, Claes M Gustafsson, N. G. Larsson
Science Advances - 2016 -
MGME1 processes flaps into ligatable nicks in concert with DNA polymerase gamma during mtDNA
replication
Jay (Jennifer) Uhler, Christian Thörn, Thomas J. Nicholls, S. Matic, D. Milenkovic, Claes M Gustafsson, Maria Falkenberg
Nucleic Acids Research - 2016 -
Mitochondrial transcription termination factor 1 directs polar replication fork
pausing
Yonghong Shi, Viktor Posse, Xuefeng Zhu, A. K. Hyvarinen, H. T. Jacobs, Maria Falkenberg, Claes M Gustafsson
Nucleic Acids Research - 2016 -
Maintenance and Expression of Mammalian Mitochondrial
DNA
Claes M Gustafsson, Maria Falkenberg, N. G. Larsson
Annual Review of Biochemistry - 2016 -
Loss of the Mediator subunit Med20 affects transcription of tRNA and other non-coding RNA genes in fission
yeast
Jonas O P Carlsten, Xuefeng Zhu, Marcela Davila Lopez, Tore Samuelsson, Claes M Gustafsson
Biochimica Et Biophysica Acta-Gene Regulatory Mechanisms - 2016 -
Simultaneous DNA and RNA Mapping of Somatic Mitochondrial Mutations across Diverse Human
Cancers.
James B Stewart, Babak Alaei-Mahabadi, Radhakrishnan Sabarinathan, Tore Samuelsson, Jan Gorodkin, Claes M Gustafsson, Erik Larsson
PLoS genetics - 2015 -
Regulation of DNA replication at the end of the mitochondrial D-loop involves the helicase TWINKLE and a conserved sequence
element
Elisabeth Jemt, Örjan Persson, Yonghong Shi, Majda Mehmedovic, Jay (Jennifer) Uhler, Marcela Davila Lopez, C. Freyer, Claes M Gustafsson, Tore Samuelsson, Maria Falkenberg
Nucleic Acids Research - 2015 -
MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA–DNA triplex
structures
Tanmoy Mondal, Santhilal Subhash, Roshan Vaid, Stefan Enroth, Sireesha Uday, Björn Reinius, Sanhita Mitra, Arif Mohammed, Alva Rani James, Emily Hoberg, Aristidis Moustakas, Ulf Gyllensten, Steven J.M. Jones, Claes M Gustafsson, Andrew H Sims, Fredrik Westerlund, Eduardo Gorab, Chandrasekhar Kanduri
Nature Communications - 2015 -
Mediator tail subunits can form amyloid-like aggregates in vivo and affect stress response in
yeast
Xuefeng Zhu, Lihua Chen, Jonas O P Carlsten, Qian Liu, Junsheng Yang, Beidong Liu, Claes M Gustafsson
Nucleic Acids Research - 2015 -
The exonuclease activity of DNA polymerase gamma is required for ligation during mitochondrial DNA
replication
Bertil Macao, Jay (Jennifer) Uhler, Triinu Siibak, Xuefeng Zhu, Yonghong Shi, Wenwen Sheng, Monica Olsson, J. B. Stewart, Claes M Gustafsson, Maria Falkenberg
Nature Communications - 2015 -
TEFM is a potent stimulator of mitochondrial transcription elongation in
vitro
Viktor Posse, S. Shahzad, Maria Falkenberg, B. M. Hallberg, Claes M Gustafsson
Nucleic Acids Research - 2015 -
Whole exome sequencing reveals mutations in NARS2 and PARS2, encoding the mitochondrial asparaginyl-tRNA synthetase and prolyl-tRNA synthetase, in patients with Alpers
syndrome.
Kalliopi Sofou, Gittan Kollberg, Maria Holmström, Marcela Davila Lopez, Niklas Darin, Claes M Gustafsson, Elisabeth Holme, Anders Oldfors, Mar Tulinius, Jorge Asin-Cayuela
Molecular genetics & genomic medicine - 2015 -
In Vivo Occupancy of Mitochondrial Single-Stranded DNA Binding Protein Supports the Strand Displacement Mode of DNA
Replication
Javier Miralles Fusté, Yonghong Shi, Sjoerd Wanrooij, Xuefeng Zhu, Elisabeth Jemt, Örjan Persson, N. Sabouri, Claes M Gustafsson, Maria Falkenberg
Plos Genetics - 2014 -
The amino terminal extension of mammalian mitochondrial RNA polymerase ensures promoter specific transcription
initiation
Viktor Posse, Emily Hoberg, Anke Dierckx, Saba Shahzad, Camilla Koolmeister, Nils-Göran Larsson, Marcus Wilhelmsson, B. Martin Hällberg, Claes M Gustafsson
Nucleic Acids Research - 2014 -
Essential Genetic Interactors of SIR2 Required for Spatial Sequestration and Asymmetrical Inheritance of Protein
Aggregates
J. Song, Q. Yang, Junsheng Yang, Lisa C Larsson, Xinxin Hao, Xuefeng Zhu, Sandra Malmgren Hill, Marija Cvijovic, Julia Fernandez-Rodriguez, Julie Grantham, Claes M Gustafsson, Beidong Liu, Thomas Nyström
PLoS Genetics - 2014 -
Mediator Can Regulate Mitotic Entry and Direct Periodic Transcription in Fission
Yeast
Gabor Banyai, Marcela Davila Lopez, Zsolt Szilagyi, Claes M Gustafsson
Molecular and Cellular Biology - 2014 -
In Vitro-Reconstituted Nucleoids Can Block Mitochondrial DNA Replication and
Transcription
G. Farge, Majda Mehmedovic, M. Baclayon, Smjl van den Wildenberg, W. H. Roos, Claes M Gustafsson, G. J. L. Wuite, Maria Falkenberg
Cell Reports - 2014 -
The UbL protein UBTD1 stably interacts with the UBE2D family of E2 ubiquitin conjugating
enzymes
Jay (Jennifer) Uhler, H. Spahr, G. Farge, S. Clavel, N. G. Larsson, Maria Falkenberg, Tore Samuelsson, Claes M Gustafsson
Biochemical and Biophysical Research Communications - 2014 -
Hereditary myopathy with early respiratory failure is associated with misfolding of the titin fibronectin III 119
subdomain
Carola Hedberg, Alejandro Gomez Toledo, Claes M Gustafsson, Göran Larson, Anders Oldfors, Bertil Macao
Neuromuscular Disorders - 2014 -
MTERF1 Binds mtDNA to Prevent Transcriptional Interference at the Light-Strand Promoter but Is Dispensable for rRNA Gene Transcription
Regulation
M. Terzioglu, B. Ruzzenente, J. Harmel, A. Mourier, Elisabeth Jemt, Marcela Davila Lopez, C. Kukat, J. B. Stewart, R. Wibom, C. Meharg, B. Habermann, Maria Falkenberg, Claes M Gustafsson, C. B. Park, N. G. Larsson
Cell Metabolism - 2013 -
The multitalented Mediator
complex
Jonas O P Carlsten, Xuefeng Zhu, Claes M Gustafsson
Trends in Biochemical Sciences - 2013 -
Emerging roles of Cdk8 in cell cycle
control
Zsolt Szilagyi, Claes M Gustafsson
Biochimica Et Biophysica Acta-Gene Regulatory Mechanisms - 2013 -
Cyclin dependent kinase 8 regulates mitotic commitment in fission
yeast
Zsolt Szilagyi, Gabor Banyai, Marcela Davila Lopez, C. I. McInerny, Claes M Gustafsson
Molecular and Cellular Biology - 2012 -
Mammalian transcription factor A is a core component of the mitochondrial transcription
machinery
Yonghong Shi, Anke Dierckx, Paulina Wanrooij, Sjoerd Wanrooij, N. G. Larsson, Marcus Wilhelmsson, Maria Falkenberg, Claes M Gustafsson
Proceedings of the National Academy of Science of the United States of America - 2012 -
A hybrid G-quadruplex structure formed between RNA and DNA explains the extraordinary stability of the mitochondrial
R-loop
Paulina Wanrooij, Jay (Jennifer) Uhler, Yonghong Shi, Fredrik Westerlund, Maria Falkenberg, Claes M Gustafsson
Nucleic Acids Research - 2012 -
LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial
mRNAs.
Benedetta Ruzzenente, Metodi D Metodiev, Anna Wredenberg, Ana Bratic, Chan Bae Park, Yolanda Cámara, Dusanka Milenkovic, Volker Zickermann, Rolf Wibom, Kjell Hultenby, Hediye Erdjument-Bromage, Paul Tempst, Ulrich Brandt, James B Stewart, Claes M Gustafsson, Nils-Göran Larsson
The EMBO journal - 2012 -
Role of human DNA glycosylase Nei-like 2 (NEIL2) and single strand break repair protein polynucleotide kinase 3'-phosphatase in maintenance of mitochondrial
genome.
Santi M Mandal, Muralidhar L Hegde, Arpita Chatterjee, Pavana M Hegde, Bartosz Szczesny, Dibyendu Banerjee, Istvan Boldogh, Rui Gao, Maria Falkenberg, Claes M Gustafsson, Partha S Sarkar, Tapas K Hazra
The Journal of biological chemistry - 2012 -
In vivo mutagenesis reveals that OriL is essential for mitochondrial DNA
replication.
Sjoerd Wanrooij, Javier Miralles Fusté, James B Stewart, Paulina H Wanrooij, Tore Samuelsson, Nils-Göran Larsson, Claes M Gustafsson, Maria Falkenberg
EMBO reports - 2012 -
Protein sliding and DNA denaturation are essential for DNA organization by human mitochondrial transcription factor
A
G. Farge, N. Laurens, O. D. Broekmans, Smjl van den Wildenberg, L. C. M. Dekker, M. Gaspari, Claes M Gustafsson, E. J. G. Peterman, Maria Falkenberg, G. J. L. Wuite
Nature Communications - 2012 -
Structure of the human MTERF4-NSUN4 protein complex that regulates mitochondrial ribosome
biogenesis
Henrik Spahr, Bianca Habermann, Claes M Gustafsson, Nils-Göran Larsson, B. Martin Hallberg
Proceedings of the National Academy of Sciences of the United States of America - 2012 -
Mediator Promotes CENP-A Incorporation at Fission Yeast
Centromeres
Jonas O P Carlsten, Zsolt Szilagyi, Beidong Liu, Marcela Davila Lopez, Erzsebet Szaszi, I. Djupedal, Thomas Nyström, K. Ekwall, Claes M Gustafsson, Xuefeng Zhu
Molecular and Cellular Biology - 2012 -
The mitochondrial DNA helicase TWINKLE can assemble on a closed circular template and support initiation of DNA
synthesis
Elisabeth Jemt, G Farge, Stefan Bäckström, T Holmlund, Claes M Gustafsson, Maria Falkenberg
NUCLEIC ACIDS RESEARCH - 2011 -
MTERF4 Regulates Translation by Targeting the Methyltransferase NSUN4 to the Mammalian Mitochondrial
Ribosome
Y Camara, Jorge Asin-Cayuela, CB Park, MB Metodiev, Yonghong Shi, B Ruzzenente, C Kukat, B Habermann, R Wibom, K Hultenby, T Franz, H Erdjument-Bromage, P Tempst, BM Hallberg, Claes M Gustafsson, NG Larsson
CELL METABOLISM - 2011 -
Adenosine Kinase Deficiency Disrupts the Methionine Cycle and Causes Hypermethioninemia, Encephalopathy, and Abnormal Liver
Function
Magnus K. Bjursell, HJ Blom, Jorge Asin-Cayuela, ML Engvall, N Lesko, S Balasubramaniam, G Brandberg, M Halldin, Maria Falkenberg, C Jakobs, D Smith, E Struys, U von Dobeln, Claes M Gustafsson, J Lundeberg, A Wedell
AMERICAN JOURNAL OF HUMAN GENETICS - 2011 -
Histone modifications influence mediator interactions with
chromatin.
Xuefeng Zhu, Yongqiang Zhang, Gudrun Bjornsdottir, Zhongle Liu, Amy Quan, Michael Costanzo, Marcela Davila Lopez, Jakub Orzechowski Westholm, Hans Ronne, Charles Boone, Claes M Gustafsson, Lawrence Myers
Nucleic acids research - 2011 -
Mediator influences telomeric silencing and cellular life
span.
Xuefeng Zhu, Beidong Liu, Jonas O P Carlsten, Jenny Beve, Thomas Nyström, Lawrence Myers, Claes M Gustafsson
Molecular and cellular biology - 2011 -
MTERF1 gives mtDNA an unusual
twist.
Claes M Gustafsson, Nils-Göran Larsson
Cell metabolism - 2010 -
Human mitochondrial transcription revisited: only TFAM and TFB2M are required for transcription of the mitochondrial genes in
vitro.
Dmitry Litonin, Marina Sologub, Yonghong Shi, Maria Savkina, Michael Anikin, Maria Falkenberg, Claes M Gustafsson, Dmitry Temiakov
The Journal of biological chemistry - 2010 -
Maintenance of respiratory chain function in mouse hearts with severely impaired mtDNA
transcription
Christoph Freyer, Chan Bae Park, Mats I. Ekstrand, Yonghong Shi, Julia Khvorostova, Rolf Wibom, Maria Falkenberg, Claes M Gustafsson, Nils-Goran Larsson
NUCLEIC ACIDS RESEARCH - 2010 -
A Chromatin-remodeling Protein Is a Component of Fission Yeast
Mediator
Olga Khorosjutina, Paulina Wanrooij, Julian Walfridsson, Zsolt Szilagyi, Xuefeng Zhu, Vera Baraznenok, Karl Ekwall, Claes M Gustafsson
JOURNAL OF BIOLOGICAL CHEMISTRY - 2010 -
LRPPRC is a mitochondrial matrix protein that is conserved in
metazoans
Fredrik H. Sterky, Benedetta Ruzzenente, Claes M Gustafsson, Tore Samuelsson, Nils-Goeran Larsson
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS - 2010 -
G-quadruplex structures in RNA stimulate mitochondrial transcription termination and primer
formation
Paulina Wanrooij, Jay (Jennifer) Uhler, Tomas Simonsson, Maria Falkenberg, Claes M Gustafsson
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA - 2010 -
Mitochondrial RNA polymerase is needed for activation of the origin of light-strand DNA
replication.
Javier Miralles Fusté, Sjoerd Wanrooij, Elisabeth Jemt, Caroline E Granycome, Tricia J Cluett, Yonghong Shi, Neli Atanassova, Ian J Holt, Claes M Gustafsson, Maria Falkenberg
Molecular cell - 2010 -
MTERF2 is a nucleoid component in mammalian
mitochondria.
Mina Pellegrini, Jorge Asin-Cayuela, Hediye Erdjument-Bromage, Paul Tempst, Nils-Goran Larsson, Claes M Gustafsson
Biochimica et Biophysica Acta - 2009 -
Cryo-EM reveals promoter DNA binding and conformational flexibility of the general transcription factor
TFIID.
Hans Elmlund, Vera Baraznenok, Tomas Linder, Zsolt Szilagyi, Reza Rofougaran, Anders Hofer, Hans Hebert, Martin Lindahl, Claes M Gustafsson
Structure - 2009 -
Methylation of 12S rRNA is necessary for in vivo stability of the small subunit of the mammalian mitochondrial
ribosome.
Metodi D Metodiev, Nicole Lesko, Chan Bae Park, Yolanda Cámara, Yonghong Shi, Rolf Wibom, Kjell Hultenby, Claes M Gustafsson, Nils-Göran Larsson
Cell metabolism - 2009 -
Distinct differences in chromatin structure at subtelomeric X and Y' elements in budding
yeast.
Xuefeng Zhu, Claes M Gustafsson
PloS one - 2009 -
Molecular phylogenetics of ascomycotal adhesins--a novel family of putative cell-surface adhesive proteins in fission
yeasts.
Tomas Linder, Claes M Gustafsson
Fungal genetics and biology : FG & B - 2008 -
Two conserved modules of Schizosaccharomyces pombe Mediator regulate distinct cellular
pathways.
Tomas Linder, Nina N Rasmussen, Camilla O Samuelsen, Emmanouella Chatzidaki, Vera Baraznenok, Jenny Beve, Peter Henriksen, Claes M Gustafsson, Steen Holmberg
Nucleic acids research - 2008 -
Human mitochondrial RNA polymerase primes lagging-strand DNA synthesis in
vitro
Sjoerd Wanrooij, Javier Miralles Fuste, Geraldine Farge, Yonghong Shi, Claes M Gustafsson, Maria Falkenberg
Proceedings of The National Academy of Sciences of The United States of America - 2008 -
Mitochondrial transcription and its regulation in mammalian
cells.
Jorge Asin-Cayuela, Claes M Gustafsson
Trends in biochemical sciences - 2007 -
MTERF3 is a negative regulator of mammalian mtDNA
transcription.
Chan Bae Park, Jorge Asin-Cayuela, Yolanda Cámara, Yonghong Shi, Mina Pellegrini, Martina Gaspari, Rolf Wibom, Kjell Hultenby, Hediye Erdjument-Bromage, Paul Tempst, Maria Falkenberg, Claes M Gustafsson, Nils-Göran Larsson
Cell - 2007 -
DNA replication and transcription in mammalian
mitochondria.
Maria Falkenberg, Nils-Göran Larsson, Claes M Gustafsson
Annual review of biochemistry - 2007 -
A genome-wide role for CHD remodelling factors and Nap1 in nucleosome
disassembly.
Julian Walfridsson, Olga Khorosjutina, Paulina Matikainen, Claes M Gustafsson, Karl Ekwall
The EMBO journal - 2007 -
Conserved sequence box II directs transcription termination and primer formation in
mitochondria.
Xuan Hoi Pham, Géraldine Farge, Yonghong Shi, Martina Gaspari, Claes M Gustafsson, Maria Falkenberg
The Journal of biological chemistry - 2006 -
Genome-wide occupancy profile of mediator and the Srb8-11 module reveals interactions with coding
regions.
Xuefeng Zhu, Marianna Wirén, Indranil Sinha, Nina N Rasmussen, Tomas Linder, Steen Holmberg, Karl Ekwall, Claes M Gustafsson
Molecular cell - 2006 -
The classical srb4-138 mutant allele causes dissociation of yeast
Mediator.
Tomas Linder, Xuefeng Zhu, Vera Baraznenok, Claes M Gustafsson
Biochemical and biophysical research communications - 2006 -
The cyclin-dependent kinase 8 module sterically blocks Mediator interactions with RNA polymerase
II.
Hans Elmlund, Vera Baraznenok, Martin Lindahl, Camilla O Samuelsen, Philip J B Koeck, Steen Holmberg, Hans Hebert, Claes M Gustafsson
Proceedings of the National Academy of Sciences of the United States of America - 2006 -
A family of putative transcription termination factors shared amongst metazoans and
plants.
Tomas Linder, Chan Bae Park, Jordi Asin-Cayuela, Mina Pellegrini, Nils-Göran Larsson, Maria Falkenberg, Tore Samuelsson, Claes M Gustafsson
Current genetics - 2005 -
The yeast Mediator complex and its
regulation.
Stefan Björklund, Claes M Gustafsson
Trends in biochemical sciences - 2005 -
RNA Pol II subunit Rpb7 promotes centromeric transcription and RNAi-directed chromatin
silencing.
Ingela Djupedal, Manuela Portoso, Henrik Spåhr, Carolina Bonilla, Claes M Gustafsson, Robin C Allshire, Karl Ekwall
Genes & development - 2005 -
The structural and functional role of Med5 in the yeast Mediator tail
module.
Jenny Béve, Guo-Zhen Hu, Lawrence C Myers, Darius Balciunas, Olivera Werngren, Kjell Hultenby, Rolf Wibom, Hans Ronne, Claes M Gustafsson
The Journal of biological chemistry - 2005 -
The human mitochondrial transcription termination factor (mTERF) is fully active in vitro in the non-phosphorylated
form.
Jorge Asin-Cayuela, Thomas Schwend, Géraldine Farge, Claes M Gustafsson
The Journal of biological chemistry - 2005 -
The mediator
complex.
Stefan Björklund, Claes M Gustafsson
Advances in protein chemistry - 2004 -
Site-specific Srb10-dependent phosphorylation of the yeast Mediator subunit Med2 regulates gene expression from the 2-microm
plasmid.
Magnus Hallberg, Gennady V Polozkov, Guo-Zhen Hu, Jenny Beve, Claes M Gustafsson, Hans Ronne, Stefan Björklund
Proceedings of the National Academy of Sciences of the United States of America - 2004 -
The Soh1/MED31 protein is an ancient component of Schizosaccharomyces pombe and Saccharomyces cerevisiae
Mediator.
Tomas Linder, Claes M Gustafsson
The Journal of biological chemistry - 2004 -
Architectural role of mitochondrial transcription factor A in maintenance of human mitochondrial
DNA.
Tomotake Kanki, Kippei Ohgaki, Martina Gaspari, Claes M Gustafsson, Atsushi Fukuoh, Narie Sasaki, Naotaka Hamasaki, Dongchon Kang
Molecular and cellular biology - 2004 -
The transcription machinery in mammalian
mitochondria.
Martina Gaspari, Nils-Göran Larsson, Claes M Gustafsson
Biochimica et biophysica acta - 2004 -
Mitochondrial transcription factor A regulates mtDNA copy number in
mammals.
Mats I Ekstrand, Maria Falkenberg, Anja Rantanen, Chan Bae Park, Martina Gaspari, Kjell Hultenby, Pierre Rustin, Claes M Gustafsson, Nils-Göran Larsson
Human molecular genetics - 2004 -
The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian
cells.
Martina Gaspari, Maria Falkenberg, Nils-Göran Larsson, Claes M Gustafsson
The EMBO journal - 2004 -
TRAP230/ARC240 and TRAP240/ARC250 Mediator subunits are functionally conserved through
evolution.
Camilla O Samuelsen, Vera Baraznenok, Olga Khorosjutina, Henrik Spahr, Thomas Kieselbach, Steen Holmberg, Claes M Gustafsson
Proceedings of the National Academy of Sciences of the United States of America - 2003 -
Mediator influences Schizosaccharomyces pombe RNA polymerase II-dependent transcription in
vitro.
Henrik Spahr, Olga Khorosjutina, Vera Baraznenok, Tomas Linder, Camilla O Samuelsen, Damien Hermand, Tomi P Mäkela, Steen Holmberg, Claes M Gustafsson
The Journal of biological chemistry - 2003 -
Characterization of the mouse genes for mitochondrial transcription factors B1 and
B2.
Anja Rantanen, Martina Gaspari, Maria Falkenberg, Claes M Gustafsson, Nils-Göran Larsson
Mammalian genome : official journal of the International Mammalian Genome Society - 2003 -
Mitochondrial transcription factors B1 and B2 activate transcription of human
mtDNA.
Maria Falkenberg, Martina Gaspari, Anja Rantanen, Aleksandra Trifunovic, Nils-Göran Larsson, Claes M Gustafsson
Nature genetics - 2002 -
Analysis of Schizosaccharomyces pombe mediator reveals a set of essential subunits conserved between yeast and metazoan
cells.
H Spåhr, C O Samuelsen, V Baraznenok, I Ernest, D Huylebroeck, J E Remacle, Tore Samuelsson, T Kieselbach, S Holmberg, Claes M Gustafsson
Proceedings of the National Academy of Sciences of the United States of America - 2001 -
Purification and characterization of RNA polymerase II holoenzyme from Schizosaccharomyces
pombe.
H Spåhr, J Bève, Thomas Larsson, Jörgen Bergström, Karl-Anders Karlsson, Claes M Gustafsson
The Journal of biological chemistry - 2000 -
The DNA ligands influence the interactions between the herpes simplex virus 1 origin binding protein and the single strand DNA-binding protein,
ICP-8.
Claes M Gustafsson, Maria Falkenberg, Stina Simonsson, Hadi Valadi, Per Elias
The Journal of biological chemistry - 1995