Xinxin Hao

Nuclear Hsp104 safeguards the dormant translation machinery during

Verena Kohler, Andreas Kohler, Lisa Larsson Berglund, Xinxin Hao, Sarah Gersing, Axel Imhof, Thomas Nyström, Johanna L Höög, Martin Ott, Claes Andreasson, Sabrina Buttner
NATURE COMMUNICATIONS - 2024

The yeast guanine nucleotide exchange factor Sec7 is a bottleneck in spatial protein quality control and detoxifies neurological disease

proteins

Roja Babazadeh, Kara Schneider, Artur Fischbach, Xinxin Hao, Bo Liu, Thomas Nyström
Scientific Reports - 2023

Calmodulin regulates protease versus co-chaperone activity of a

metacaspase

Anna Maria Eisele-Bürger, Frederik Eisele, Sandra Malmgren Hill, Xinxin Hao, Kara Schneider, Rahmi Imamoglu, David Balchin, Beidong Liu, F. Ulrich Hartl, Peter V. Bozhkov, Thomas Nyström
Cell Reports - 2023

The GET pathway is a major bottleneck for maintaining proteostasis in Saccharomyces

cerevisiae

Rebecca Josefson, Navinder Kumar, Xinxin Hao, Beidong Liu, Thomas Nyström
Scientific Reports - 2023

Artificial Hsp104-mediated systems for re-localizing protein

aggregates

Artur Fischbach, Angela Johns, Kara Schneider, Xinxin Hao, P. Tessarz, Thomas Nyström
Nature Communications - 2023

Lsm7 phase-separated condensates trigger stress granule

formation

Michelle Lindström, Lihua Chen, Shan Jiang, Dan Zhang, Yuan Gao, J. Zheng, Xinxin Hao, Xiaoxue Yang, Arpitha Kabbinale, Johannes Thoma, Lisa Metzger, D. Y. Zhang, Xuefeng Zhu, H. S. Liu, Claes M Gustafsson, Björn Marcus Burmann, J. Winderickx, Per Sunnerhagen, Beidong Liu
Nature Communications - 2022

An Hsp90 co-chaperone links protein folding and degradation and is part of a conserved protein quality

control

Frederik Eisele, Anna Maria Eisele-Bürger, Xinxin Hao, Lisa Larsson Berglund, Johanna L Höög, Beidong Liu, Thomas Nyström
Cell Reports - 2021

Genome-wide imaging screen uncovers molecular determinants of arsenite-induced protein aggregation and

toxicity.

Stefanie Andersson, Antonia Romero, Joana Isabel Rodrigues, Sansan Hua, Xinxin Hao, Therese Jacobson, Vivien Karl, Nathalie Becker, Arghavan Ashouri, Sebastien Rauch, Thomas Nyström, Beidong Liu, Markus J. Tamás
Journal of cell science - 2021

FMN reduces Amyloid-beta toxicity in yeast by regulating redox status and cellular

metabolism

X. Chen, B. Y. Ji, Xinxin Hao, X. W. Li, Frederik Eisele, Thomas Nyström, D. Petranovic
Nature Communications - 2020

Yeast mismatch repair components are required for stable inheritance of gene

silencing

Qian Liu, Xuefeng Zhu, Michelle Lindström, Yonghong Shi, Ju Zheng, Xinxin Hao, Claes M Gustafsson, Beidong Liu
Plos Genetics - 2020

Syntaxin 5 Is Required for the Formation and Clearance of Protein Inclusions during Proteostatic

Stress

Roja Babazadeh, Doryaneh Ahmadpour, S. Jia, Xinxin Hao, Per O Widlund, Kara Schneider, Frederik Eisele, L. D. Edo, G. J. Smits, Beidong Liu, Thomas Nyström
Cell Reports - 2019

Loss of transcriptional control affects As(III)-induced protein

aggregation

Joana Isabel Rodrigues, Stefanie Andersson, Sansan Hua, Xinxin Hao, Therese Jacobson, Vivien Karl, Arghavan Ashouri, Thomas Nyström, Beidong Liu, Markus J. Tamás
Gordon Research Conference on Stress Proteins in Growth, Development & Disease 2019, Lucca, Italy - 2019

Genome-wide imaging screen uncovers molecular determinants of arsenite-induced protein aggregation and

toxicity

Stefanie Andersson, Joana Isabel Rodrigues, Antonia Romero, Sansan Hua, Xinxin Hao, Therese Jacobson, Vivien Karl, Arghavan Ashouri, José García-Martínez, José Enrique Pérez-Ortín3 Pérez-Ortín, Thomas Nyström, Beidong Liu, Markus J. Tamás
International Conference on Yeast Genetics and Molecular Biology, Gothenburg, Sweden, workshop presentation (2019) - 2019

Role of the ribosomal quality control machinery in nucleocytoplasmic translocation of polyQ-expanded huntingtin

exon-1

Ju Zheng, Junsheng Yang, Y. J. Choe, Xinxin Hao, Xiuling Cao, Q. Zhao, Y. J. Zhang, V. Franssens, F. U. Hartl, Thomas Nyström, J. Winderickx, Beidong Liu
Biochemical and Biophysical Research Communications - 2017

Differential effects of soluble and aggregating polyQ proteins on cytotoxicity and type-1 myosin-dependent endocytosis in

yeast

Lisa Larsson Berglund, Xinxin Hao, Beidong Liu, Julie Grantham, Thomas Nyström
Scientific Reports - 2017

Spatial sequestration and detoxification of Huntingtin by the ribosome quality control

complex

Junsheng Yang, Xinxin Hao, Xiuling Cao, Beidong Liu, Thomas Nyström
Elife - 2016

Asymmetric Inheritance of Aggregated Proteins and Age Reset in Yeast Are Regulated by Vac17-Dependent Vacuolar

Functions

Sandra Malmgren Hill, Xinxin Hao, Johan Grönvall, Stephanie Spikings-Nordby, Per O Widlund, T. Amen, Anna Jorhov, Rebecca Josefson, D. Kaganovich, Beidong Liu, Thomas Nyström
Cell Reports - 2016

Essential Genetic Interactors of SIR2 Required for Spatial Sequestration and Asymmetrical Inheritance of Protein

Aggregates

J. Song, Q. Yang, Junsheng Yang, Lisa C Larsson, Xinxin Hao, Xuefeng Zhu, Sandra Malmgren Hill, Marija Cvijovic, Julia Fernandez-Rodriguez, Julie Grantham, Claes M Gustafsson, Beidong Liu, Thomas Nyström
PLoS Genetics - 2014

Stress granule-defective mutants deregulate stress responsive

transcripts

Xiaoxue Yang, Yi Shen, Elena Garre, Xinxin Hao, Daniel Krumlinde, Marija Cvijovic, Christina Arens, Thomas Nyström, Beidong Liu, Per Sunnerhagen
PLoS Genetics - 2014

Life-span extension by a metacaspase in the yeast Saccharomyces

cerevisiae

Sandra Malmgren Hill, Xinxin Hao, Beidong Liu, Thomas Nyström
Science - 2014

Absence of mitochondrial translation control proteins extends life span by activating sirtuin-dependent

silencing.

Antonio Caballero, Ana Ugidos, Beidong Liu, David Öling, Kristian Kvint, Xinxin Hao, Cora Mignat, Laurence Nachin, Mikael Molin, Thomas Nyström
Molecular cell - 2011

Segregation of protein aggregates involves actin and the polarity

machinery.

Beidong Liu, Lisa C Larsson, Vanessa Franssens, Xinxin Hao, Sandra Malmgren Hill, Veronica Andersson, Daniel Höglund, Jia Song, Xiaoxue Yang, David Öling, Julie Grantham, Joris Winderickx, Thomas Nyström
Cell - 2011

The Polarisome Is Required for Segregation and Retrograde Transport of Protein

Aggregates

Beidong Liu, Lisa C Larsson, Antonio Caballero, Xinxin Hao, David Öling, Julie Grantham, Thomas Nyström
Cell - 2010

Xinxin Hao

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