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Please click here for a compilation of my publications by Google scholar, including citation metrics and many full-text links.




  • Huijbers PMSC, Larsson DGJ, Flach C-F. (2020). Surveillance of antibiotic resistant Escherichia coli in human populations through urban wastewater in ten European countries. Environmental pollution. Accepted for publication.
  • Böhm M-E, Razavi M, Marathe NP, Flach C-F, Larsson DGJ. (2020). Discovery of a novel integron-borne aminoglycoside resistance gene present in clinical pathogens by screening environmental bacterial communities. Microbiome. In press.
  • Laxminarayan R, Van Boeckel T, Frost I, Kariuki S, Khan E, Limmathurotsakul D, Larsson DGJ, Levy-Hara G, Mendelson M, Outterson K, Peacock S, Zhu Y-G. (2020). The Lancet Infectious Diseases Commission on antimicrobial resistance: six years later. Lancet Infect Dis. DOI: https://doi.org/10.1016/S1473-3099(20)30003-7




  • Rutgersson C, Ebmeyer S, Lassen SB, Karkman A, Fick J, Kristiansson K, Brandt KK, Flach C-F, Larsson DGJ. (2019). Long-term application of Swedish sewage sludge on farmland does not cause clear changes in the soil bacterial resistome. Environ Int. 137:105339. doi: 10.1016/j.envint.2019.105339
  • Marathe NP, Salvà-Serra F, Karlsson R, Larsson DGJ, Moore ERB, Svensson-Stadler L, Jakobsson HE. (2019). Scandinavium goeteborgense gen. nov., sp. nov., a new member of the family Enterobacteriaceae isolated from a wound infection, carries a novel quinolone-resistance gene variant. Front Microbiol. 10:2511. doi: 10.3389/fmicb.2019.02511
  • Nijsingh N, Munthe C, Larsson DGJ. (2019) Managing pollution from antibiotics manufacturing: charting actors, incentives and disincentives. Environmental Health 18:95. https://ehjournal.biomedcentral.com/articles/10.1186/s12940-019-0531-1.
  • Ebmeyer S, Kristiansson E, Larsson DGJ. (2019). The mobile FOX AmpC beta-lactamases originated in Aeromonas allosaccharophila. Int J Antimicrob Agents. 54(6):798-802. https://doi.org/10.1016/j.ijantimicag.2019.09.017
  • Munthe C, Nijsingh N, de Fine Lich K, Larsson DGJ. (2019). The Ethics of Antibiotic Resistance: Towards an Agenda for Feasible and Justified Global Health Policy. Bioethics.  33(7):731-733. https://doi.org/10.1111/bioe.12655
  • Monjas L, Fodran P, Kollback J, Cassani C, Olsson T, Genheden M, Larsson DGJ, Wallentin C-J. (2019). Synthesis and biological evaluation of truncated derivatives of abyssomicin C as antibacterial agents. Beilstein J. Org. Chem. 15:1468–1474. DOI:10.3762/bjoc.15.147
  • Marathe NP, Berglund F, Razavi M, Pal C, Dröge J, Samant S, Kristiansson E, Larsson DGJ. (2019). Sewage effluent from an Indian hospital harbors novel carbapenemases and integron-borne antibiotic resistance genes. Microbiome. 7:97. https://doi.org/10.1186/s40168-019-0710-x
  • Huijbers PMC, Flach C-F, Larsson DGJ. (2019). A conceptual framework for the environmental surveillance of antibiotics and antibiotic resistance. Environ Int. 130:104880. https://doi.org/10.1016/j.envint.2019.05.074
  • Hutinel M, Huijbers PMC, Fick J, Åhrén C, Larsson DGJ, Flach CF. (2019). Population-level surveillance of antibiotic resistance in Escherichia coli through sewage analysis. Euro Surveill. 24(37). pii=1800497. https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2019.24.37.1800497
  • Hendriksen RS, Munk P, Niage P, van Bunnik B,…., Larsson DGJ,….(ca 100 co-authors). (2019). Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage. Nature commun. 10, 1124. https://doi.org/10.1038/s41467-019-08853-3
  • Berglund F, Österlund T, Boulund F, Marathe NP, Larsson DGJ, Kristiansson E. (2019). Identification and reconstruction of novel antibiotic resistance genes from metagenomes. Microbiome. 7:52. https://doi.org/10.1186/s40168-019-0670-1.
  • Munthe C, Nijsingh N, de Fine Licht K, Larsson DGJ. (2019). Health-related research ethics and social value: antibiotic resistance intervention research and pragmatic risks. Bioethics, 33:335–342. DOI: doi.org/10.1111/bioe.12580
  • Ebmeyer S, Kristiansson E, Larsson DGJ. (2019). CMY-1/MOX-family AmpC beta-lactamases MOX-1, MOX-2 and MOX-9 were mobilized independently from three Aeromonas species. J Antimicrob Chemother. 5:1202. https://doi.org/10.1093/jac/dkz025
  • Karkman A., Pärnänen K. and Larsson DGJ. (2019). Fecal pollution can explain antibiotic resistance gene abundances in anthropogenically impacted environments. Nature Commun. 80:10. DOI: https://www.nature.com/articles/s41467-018-07992-3


  • Aga D, Davies J, Gandra S, Kasprzyk B, Larsson DGJ, McLain J, Singer A, Snape J, Slijkhuis H, Sweetman A, Voulvoulis N. (2018). Antimicrobial manufacturing waste. Pages 30-45. In: Initiatives for Addressing Antimicrobial Resistance in the Environment: Current Situation and Challenges. https://wellcome.ac.uk/sites/default/files/antimicrobial-resistance-environment-report.pdf
  • Sahlin S, Larsson DGJ, Ågerstrand M. (2018). Ciprofloxacin EQS data overview. ACES report number 15. https://www.aces.su.se/aces/wp-content/uploads/2018/11/Ciprofloxacin-EQS-data-overview-2018.pdf
  • Kotsakis S, Flach CF, Razavi M, Larsson DGJ. (2018). Characterization of the first OXA-10 natural variant with increased carbapenemase activity. Antimicrob Agents  Chemother. 63 (1). e01817-18. https://aac.asm.org/content/early/2018/10/31/AAC.01817-18.long
  • Pärnänen K, Karkman A, Hultman J, Lyra C, Bengtsson-Palme J, Larsson DGJ, Rautava S, Salminen S, Kumar H, Satokari R, Isolauri E, Virta M. (2018). Maternal gut and breast milk microbiota affect infant gut antibiotic resistome and mobile genetic elements. Nat Commun. 9, Article Number 3891. https://doi.org/10.1038/s41467-018-06393-w
  • Flach CF, Genheden M, Fick J, Larsson DGJ. (2018). A comprehensive screening of E. coli isolates from Scandinavia’s largest sewage treatment plant indicates no selection for antibiotic resistance. Environ Sci Technol, 52 (19), pp 11419–11428. https://pubs.acs.org/doi/10.1021/acs.est.8b03354
  • Wang H, Sikora P, Rutgersson C, Lindh M, Brodin T, Björlenius B, Larsson DGJ, Norder H. (2018). Differential removal of human pathogenic viruses from sewage by conventional and ozone treatments. Int J Hyg Environ Health. 221:479-488. DOI: 10.1016/j.ijheh.2018.01.012.
  • Pohl J, Björlenius B, Brodin T, Carlsson G, Fick J, Larsson DGJ, Norrgren L, Stefan Örn S. (2018). Effects of ozonated sewage effluent on reproduction and behavioral endpoints in zebrafish (Danio rerio). Aquat Toxicol. 200:93-101. https://doi.org/10.1016/j.aquatox.2018.04.014
  • Larsson DGJ, Andremont A, Bengtsson-Palme J, Koefoed Brandt K, de Roda Husman AM, Fagerstedt P, Fick J, Flach CF, Gaze WH, Kuroda M, Kvint K, Laxminarayan R, Manaia CM, Nielsen KM, Plant L, Ploy MC, Segovia C, Simonet P, Smalla K, Snape J, Topp E, van Hengel A, Verner-Jeffreys DW, Virta MPJ, Wellington EM, Wernersson AS. (2018). Critical knowledge gaps and research needs related to the environmental dimensions of antibiotic resistance. Environ Int. 117:132-138. https://doi.org/10.1016/j.envint.2018.04.041
  • Kraupner N, Ebmeyer S, Bengtsson-Palme J, Fick J, Kristiansson E, Flach C-F, Larsson DGJ. (2018). Selective concentration for ciprofloxacin resistance in Escherichia coli grown in complex aquatic bacterial biofilms. Environ Int. 116:255-268. https://doi.org/10.1016/j.envint.2018.04.029
  • Nijsingh N, Larsson DGJ, Persson de Fine Licht K, Munthe C. (2018). Justifying Antibiotic Resistance Interventions: Uncertainty, Precaution and Ethics. In: Jamrozik E., Selgelid M.J. (eds) Ethics and Drug-Resistant Infections: Collective Responsibility for Global Public Health. Public Health Ethics Analysis, vol 5. Springer, Cham. https://gup.ub.gu.se/file/207573
  • Topp E, Larsson DGJ, Miller D, Van den Eede C, Virta M. (2018). Antimicrobial resistance and the environment: Assessment of advances, gaps and recommendations for agriculture, aquaculture and pharmaceutical manufacturing. FEMS Microbiol Ecol. 93, fix185. DOI: 10.1093/femsec/fix185
  • Larsson DGJ. (2018). Risks of using the natural defense of commensal bacteria as antibiotics call for research and regulation. Int J Antimicrob Agents, vol 51, issue 2277-278. https://doi.org/10.1016/j.ijantimicag.2017.12.018
  • Bengtsson-Palme J, Gunnarsson L, Larsson DGJ. (2018). Can branding and price of pharmaceuticals guide informed choices towards improved pollution control during manufacturing? J Clean Prod. 171:137. https://doi.org/10.1016/j.jclepro.2017.09.247
  • Marathe NP, Janzon A, Kotsakis SD, Flach C-F, Razavi M, Berglund F, Kristiansson E, Larsson DGJ. (2018). Functional metagenomics reveals a novel carbapenem-hydrolyzing mobile beta-lactamase from Indian river sediments contaminated with antibiotic production waste. Environ Int. 112:279-286. http://doi.org/10.1016/j.envint.2017.12.036
  • Bengtsson-Palme J, Larsson DGJ. (2018). Protection goals must guide risk assessment for antibiotics. Environ int. 11(352). http://dx.doi.org/10.1016/j.envint.2017.10.019
  • Jutkina J, Marathe NP, Flach C-F, Larsson DGJ. (2018). Antibiotics and common antibacterial biocides stimulate horizontal transfer of resistance at low concentrations. Sci Total Environ. 616-617:172. https://doi.org/10.1016/j.scitotenv.2017.10.312
  • Bengtsson-Palme J, Kristiansson E, Larsson DGJ. (2018). Environmental factors influencing the development and spread of antibiotic resistance. FEMS Micro Rev. 1;42. https://doi.org/10.1093/femsre/fux053




  • Mohammad Razavi; Nachiket P. Marathe; Michael R Gillings; Carl-Fredrik Flach; Erik Kristiansson; Larsson DGJ. (2017). Discovery of the fourth mobile sulfonamide resistance gene. Microbiome. 5:160. https://doi.org/10.1186/s40168-017-0379-y
  • Berglund F, Nachiket MP, Österlund T, Bengtsson-Palme J, Kotsakis S, Flach CF, Larsson DGJ, Kristiansson E. (2017). Identification of 76 novel B1 metallo-β-lactamases through large-scale screening of genomic and metagenomic data. Microbiome. 5:134. https://doi.org/10.1186/s40168-017-0353-8
  • Boulund F, Berglund F, Flach CF, Bengtsson-Palme J, Marathe NP, Larsson DGJ, Kristiansson E. (2017). Computational discovery and functional validation of novel fluoroquinolone resistance genes in public metagenomic data sets. BMC Genomics. 18:682. https://doi.org/10.1186/s12864-017-4064-0
  • Marathe MP, Pal C, Gaikwad SS, Jonsson V, Kristiansson E, Larsson DGJ. (2017). Untreated urban waste contaminates Indian river sediments with resistance genes to last resort antibiotics. Water Res. 124:388. https://doi.org/10.1016/j.watres.2017.07.060
  • Bengtsson-Palme J, Larsson DGJ, Kristiansson E. (2017). Using metagenomics to investigate human and environmental resistomes. J Antimicrob Chemother. 72:2690. https://doi.org/10.1093/jac/dkx199
  • Näslund J, Fick J, Asker N, Ekman E, Larsson DGJ, Norrgren L. (2017). Diclofenac affects kidney histopathology in the three-spined stickleback (Gasterosteus aculeatus) at low µg/L concentrations. Aquat Toxicol. 189:87. https://doi.org/10.1016/j.aquatox.2017.05.017
  • Flach CF, Pal C, Svensson CJ, Kristiansson E, Östman M, Bengtsson-Palme J, Tysklind M, Larsson DGJ. (2017). Does antifouling paint select for antibiotic resistance? Sci Total Environ. 590–591:461. https://doi.org/10.1016/j.scitotenv.2017.01.213
  • Hao X*, Li X*, Pal C*, Hobman J, Rosen BP, Larsson DGJ, Saquib Q, Alwathnani HA, Zhu Y-G, Rensing C. (2017). Bacterial resistance to arsenic protects against protist killing. Biometals. 30:307. https://dx.doi.org/10.1007/s10534-017-0003-4 (*-co-first authors).
  • Pal C, Asiani K, Arya S, Rensing C, Stekel DJ, Larsson DGJ, Hobman JL. (2017). Metal resistance and its association with antibiotic resistance. Adv Microb Physiol. 70:261 ISBN: 9780128123867. https://doi.org/10.1016/bs.ampbs.2017.02.001


  • Marathe MP, Shetty SA, Shouche YS, Larsson DGJ. (2016). Limited bacterial diversity within a treatment plant receiving antibiotic-containing waste from bulk drug production. PloS One 11(11):e0165914. https://doi.org/10.1371/journal.pone.0165914
  • Bengtsson-Palme J, Larsson DGJ (2016). Why limit antibiotic pollution? The role of environmental selection in antibiotic resistance development. APUA Newsletter, 34:6
  • Pal C, Bengtsson-Palme J, Kristiansson E, Larsson DGJ. (2016). The structure and diversity of human, animal and environmental resistomes. Microbiome. 4:54. https://doi.org/10.1186/s40168-016-0199-5
  • Bengtsson-Palme J, Hammarén R, Pal C, Östman M, Björlenius B, Flach C-F, Fick J, Kristiansson E, Tysklind M, Larsson DGJ. (2016). Elucidating selection processes for antibiotic resistance in sewage treatment plants using metagenomics. Sci Total Environ. 572:697. https://doi.org/10.1016/j.scitotenv.2016.06.228
  • De Roda Husman A-M, Larsson DGJ (2016). Risk assessment and risk management of antimicrobial resistance in the environment. AMR control 2016:104 Global Health Dynamics, UK. 
  • Rönnerstrand B, Jagers S, Larsson DGJ (2016). Who worries about antibiotic resistance? (In Swedish). In: Ekvilibrium (Eds. Henrik Oscarsson, Jonas Ohlsson and Maria Solevid). SOM-institutet, University of Gothenburg. ISBN 978-91-89673-35-9.
  • Larsson DGJ, Svennerholm A-M (2016). The role of antibacterial agents in the development of antibiotic resistance (in Swedish). Läkartidningen 2016;113:D44E.
  • Bengtsson-Palme J and Larsson DGJ. (2016) Time to limit antibiotic pollution. The medicine maker, April:17 (opinion paper) (pdf)
  • Lundström SV, Östman M, Bengtsson-Palme J, Rutgersson C, Thoudal M, Sircar T, Blanck H, Eriksson KM, Tysklind M, Flach CF, Larsson DGJ. (2016) Minimal selective concentrations of tetracycline in complex aquatic bacterial biofilms. Sci Total Environ. 553:587. https://doi.org/10.1016/j.scitotenv.2016.02.103
  • Jutkina J, Rutgersson C, Flach CF, Larsson DGJ. (2016). An assay for determining minimal concentrations of antibiotics that drive horizontal transfer of resistance. Sci Total Environ. 548–549:131. https://doi.org/10.1016/j.scitotenv.2016.01.044

  • Bengtsson-Palme J, Larsson DGJ. (2016). Concentrations of antibiotics predicted to select for resistant bacteria: Proposed limits for environmental regulation. Environ Int. 86:140. https://doi.org/10.1016/j.envint.2015.10.015


  • Johnning A, Kristiansson E, Fick J, Weijdegard B, Larsson DGJ. (2015) Resistance mutations in gyrA and parC are common in Escherichia communities of both fluoroquinolone-polluted and uncontaminated aquatic environments. Front. Microbiol. 6:1355. https://doi.org/10.3389/fmicb.2015.01355
  • Pal C, Bengtsson-Palme J, Kristiansson E, Larsson DGJ. (2015) Co-occurrence of resistance genes to antibiotics, biocides and metals reveals novel insights into their co-selection potential. BMC Genomics. 16:964. https://doi.org/10.1186/s12864-015-2153-5
  • Johnning A, Kristiansson E, Martin A, Marathe NP, Shouche YS, Johansson A, Larsson DGJ. (2015) Quinolone resistance mutations in the faecal microbiota of Swedish travellers to India. BMC Microbiology. 15:235. https://doi.org/10.1186/s12866-015-0574-6
  • Bengtsson-Palme J, Angelin M, Huss M, Kjellqvist S, Kristiansson E, Palmgren H, Larsson DGJ, Johansson A. (2015) The human gut microbiome as a transporter of antibiotic resistance genes between continents. Antimicrob Agents and Chemother. 59:6551. doi: 10.1128/AAC.00933-15

  • Sandegren L, Salin K, Larsson DGJ. (2015) The environmental dimension of antibiotic resistance. In: Uppsala Health Summit – a world without antibiotics. Post-conference report. Pp 17-21. www.uppsalahealthsummit.se.
  • Flach CF, Johnning A, Nilsson I, Smalla K, Kristiansson E, Larsson DGJ. (2015) Isolation of novel IncA/C and IncN fluoroquinolone resistance plasmids from an antibiotic-polluted lake. J Antimicrob Chemother. 70:2709 doi: 10.1093/jac/dkv167
  • Bylander A, Gunnarsson L, Shao R, Billig H, Larsson DGJ. (2015) Progesterone-mediated effects on gene expression and oocyte-cumulus complex transport in the mouse fallopian tube. Reprod Biol Endocrinol. 13:40 doi: 10.1186/s12958-015-0038-8
  • Ågerstrand M, Berg C, Björlenius B, Breitholtz M, Brunstrom B,
    Fick J, Gunnarsson L, Larsson DGJ, Sumpter JP, Tysklind M, and Rudén C. (2015) Improving environmental risk assessment of human pharmaceuticals. Environ Sci Technol. 49:5336 DOI: 10.1021/acs.est.5b00302
  • Bengtsson-Palme J, Hartmann M, Eriksson KM, Pal C, Thorell K, Larsson DGJ, Nilsson RH. (2015) METAXA2 – Improved Identification and Taxonomic Classification of Small and Large Subunit rRNA in Metagenomic Data, Mol Ecol Resour, 15:1403 DOI: 10.1111/1755-0998.12399.
  • Carney Almroth BM, Gunnarsson LM, Cuklev F, Fick J, Kristiansson E, Larsson DGJ. (2015) Waterborne beclomethasone diproprionate affects the physiology of fish while its metabolite beclomethasone is not taken up. Sci Total Environ. 511:37  doi:10.1016/j.scitotenv.2014.12.016
  • Bengtsson-Palme J, Larsson DGJ. (2015) Antibiotic resistance genes in the environment: prioritizing risks. Nature Rev Microbiol. 13:396. doi:10.1038/nrmicro3399-c-1
  • Larsson DGJ and Sandegren L. (2015) The environmental dimension of antibiotic resistance. In: Uppsala Health Summit – a world without antibiotics. Pre-conference report. Pp 16-19 www.uppsalahealthsummit.se.
  • Wernersson A-S et al (in total 46 authors). (2015) The European technical report on aquatic effect-based monitoring tools under the water framework directive. Environmental Sciences Europe. 27:7 doi:10.1186/s12302-015-0039-4.


  • Bengtsson-Palme J, Boulund F, Fick J, Kristiansson E, Larsson DGJ. (2014) Shotgun metagenomics reveals a wide array of antibiotic resistance genes and mobile elements in a polluted lake in India. Front. Microbiol. 5:648 doi: 10.3389/fmicb.2014.00648
  • Rutgersson C, Fick J, Marathe N, Kristiansson E, Janzon A, Angelin M, Johansson A, Shouche Y, Flach CF, Larsson DGJ. (2014) Fluoroquinolones and qnr genes in sediment, water, soil and human fecal flora in an environment polluted by manufacturing discharges. Environ Sci Technol 48:7825 http://dx.doi.org/10.1021/es501452a
  • Grabicova K, Lindberg RH, Östman M, Grabic R, Randak T, Larsson DGJ, Fick J. (2014) Tissue-specific bioconcentration of antidepressants in fish exposed to effluent from a municipal sewage treatment plant. Sci Total Environ. 488-489:46 doi:10.1016/j.scitotenv.2014.04.052
  • Brown JN, Samuelsson L, Bernardi G, Gooneratne R, Larsson DGJ. (2014) Aqueous and Lipid NMR Metabolomic Profiling of the Earthworm Aporrectodea caliginosa shows Potential as Indicators for Studying the Effects of Differing Landuses. Environmental Toxicology and Chemistry. Vol 33:2313 http://dx.doi.org/10.1002/etc.2680
  • Pal C, Bengtsson-Palme J, Rensing C, Kristiansson E, Larsson DGJ. (2014) BacMet: antibacterial biocide and metal resistance genes database. Nucleic Acids Res, 42:D737. doi: 10.1093/nar/gkt1252.
  • Graham DW, Collignon P, Davies J, Larsson DGJ, Snape J. (2014) Underappreciated role of regionally poor water quality on globally increasing antibiotic resistance. Environ Sci Technol. 48:11746. http://doi.org/10.1021/es504206x
  • Larsson DGJ. (2014) Pollution from drug manufacturing: review and perspectives. Philos Trans R Soc Lond B Biol Sci 369:20130571 http://dx.doi.org/10.1098/rstb.2013.0571
  • Kookana RS, Williams M, Boxall AB , Larsson DGJ, Gaw S, Choi K, Yamamoto H, Shashidhar T, Zhu Y-G, Carriquiriborde P. (2014) Potential Ecological Footprints of Active Pharmaceutical Ingredients: An Examination of Risk Factors in Low-, Middle-, and High-income Countries. Philos Trans R Soc Lond B Biol Sci. 369:20130586 http://dx.doi.org/10.1098/rstb.2013.0586
  • Larsson DGJ. (2014) Antibiotics and antibiotic resistance in the external environment (in Swedish). Chapter in a popular science book on Antibiotic resistance (Antibiotika - boten och hoten) within the publication series “Formas fokuserar”. ISBN 978-91-540-6082-5. Pp 63-72
  • Larsson DGJ. (2014) Antibiotics in the environment. Ups J Med Sci. 119:108 doi:10.3109/03009734.2014.896438.
  • Larsson DGJ and Greko C. (2014) Great drugs in the wrong place: risks for environmental effects and resistance promotion (in Swedish). Läkartidningen 111:619 Online copy available here.
  • Larsson DGJ and Lööf L. (2014) Läkemedel i miljön. In: Läkemedelsboken 2014, edited and produced by the Swedish Medical Products Agency. Pp 1267-1279 Also available at www.lakemedelsboken.se
  • Selvaraj KK, Shanmugam G, Sampath S, Larsson DGJ, Ramaswamy BR. (2013) GC-MS determination of bisphenol A and alkylphenol ethoxylates in the river water from India and their ecotoxicological risk assessment. Ecotoxicol Environ Saf. 99:13 doi:10.1016/j.ecoenv.2013.09.006.


  • Flach CF, Boulund F, Kristiansson E, Larsson DGJ. (2013) Functional verification of computationally predicted qnr genes. Ann Clin Microbiol Antimicrob. 12:34 doi:10.1186/1476-0711-12-34.
  • Johnning A, Moore ERB, Svensson-Stadler L, Shouche YS, Larsson DGJ, Kristiansson E. (2013) Acquired genetic mechanisms of a multiresistant bacterium isolated from a treatment plant receiving wastewater from antibiotic production. Appl Environ Microbiol. 79:7256 doi:10.1128/AEM.02141-13.
  • Marathe NP, Regina VR, Walujkar SA, Charan SS, Moore ERB, Charan SS, Moore ERB, Larsson DGJ, Shouche YS. (2013) A Treatment Plant Receiving Waste Water from Multiple Bulk Drug Manufacturers Is a Reservoir for Highly Multi-Drug Resistant Integron-Bearing Bacteria. PLoS ONE 8(10):e77310 doi:10.1371/journal.pone.0077310
  • Shanmugam G, Sampath S, Selvaraj KK, Larsson DGJ, Ramaswamy BR. (2013) Non-steroidal anti inflammatory drugs in Indian rivers. Environ Sci Pollut Res Int. 21:921 doi:10.1007/s11356-013-1957-6.
  • Bylander A, Lind K, Goksör M, Billig H, Larsson DGJ. (2013) The classical progesterone receptor mediates the rapid reduction of fallopian tube ciliary beat frequency by progesterone. Reprod Biol Endocrinol. 11:33. doi:10.1186/1477-7827-11-33.
  • Kristiansson E, Österlund T, Gunnarsson G, Arne G, Larsson DGJ, Nerman O. (2013) A novel method for cross-species gene expression analysis. BMC Bioinformatics. 14:70. doi:10.1186/1471-2105-14-70.
  • Asker N, Kristiansson E, Albertsson E, Larsson DGJ, Förlin L. (2013) Hepatic transcriptome profiling indicates differential mRNA expression of apoptosis and immune related genes in eelpout (Zoarces viviparus) caught at Göteborg harbor, Sweden. Aquat Toxicol. 130–131:58 doi:10.1016/j.aquatox.2012.12.017.
  • Rutgersson C, Gunnarsson L, Kristiansson E, Larsson DGJ. (2013) Oral exposure to industrial effluent with exceptionally high levels of drugs does not indicate acute toxic effects in rats. Environ Toxicol Chem. 32:577 doi:10.1002/etc.2105.
  • Beijer K, Gao K, Jönsson M, Larsson DGJ, Brunström B, Brandt I. (2013) Effluent from drug manufacturing affects cytochrome P450 1 regulation and function in fish. Chemosphere 90: 1149 doi:10.1016/j.chemosphere.2012.09.023.
  • Kullgren A, Jutfelt F, Fontanillas R, Sundell K, Samuelsson LM, Wiklander K, Kling P, Koppe W, Larsson DGJ, Björnsson B-T, Jönsson E. (2013) The impact of temperature on the metabolome and endocrine metabolic signaling in Atlantic salmon (Salmo salar). Comp Biochem Physiol A Mol Integr Physiol. 164:44 doi:10.1016/j.cbpa.2012.10.005.
  • Ashbolt NJ, Amézquita A, Backhaus T, Borriello SP, Brandt KK, Collignon P, Coors A, Finley R, Gaze WH, Heberer T, Lawrence J, Larsson DGJ, McEwen SA, Ryan JJ, Schönfeld J, Silley P, Snape JR, van den Eede C, Topp E. (2013) Human health risk assessment (HHRA) for environmental development and transfer of antibiotic resistance. Environ Health Perspect. 121:993 doi:10.1289/ehp.1206316.
  • Pruden A, Larsson DGJ*, Amézquita A, Collignon P, Brandt KK, Graham DW, Lazorchak JR, Suzuki S, Silley P, Snape JR, Topp E, Zhang T, Zhu Y-G. (2013) Management Options For Reducing The Release Of Antibiotics And Antibiotic Resistance Genes To The Environment. Environ Health Perspect. 121:878 doi:10.1289/ehp.1206446. *corresponding author and shared first author.
  • Finley RL, Collignon P, Larsson DGJ, McEwen SA, Li X-Z, Gaze WH, Wright GD, Reid-Smith R, Timinouni M, Ryan JJ, Woodland C, Graham DW, Topp E. (2013) The scourge of antibiotic resistance: the important role of the environment. Clin Infect Dis. 57:704 doi:10.1093/cid/cit355.
  • Gaze WH, Krone SM, Larsson DGJ, Li XZ, Robinson JA, Simonet P, Smalla K, Timinouni M, Topp E, Wellington EM, Wright GD, Zhu YG. (2013) Influence of humans on evolution and mobilization of environmental antibiotic resistome. Emerg Infect Dis. 19(7) doi:10.3201/eid1907.120871.


  • Boulund F, Johnning A, Pereira MB, Larsson DGJ, Kristiansson E. (2012) A novel method to discover fluoroquinolone antibiotic resistance (qnr) genes in fragmented nucleotide sequences. BMC Genomics. 13:695. doi:10.1186/1471-2164-13-695.
  • Albertsson A, Rad A, Sturve J, Larsson DGJ, Förlin L. (2012) Carbonyl reductase mRNA abundance and enzymatic activity as potential biomarkers of oxidative stress in marine fish. Mar Environ Res. 80:56 doi:10.1016/j.marenvres.2012.07.001.
  • Cuklev F, Fick J, Cvijovic M, Kristiansson E, Förlin L, Larsson DGJ. (2012) Does ketoprofen or diclofenac pose the lowest risk to fish? J Hazard Mater. 229-230:100 doi:10.1016/j.jhazmat.2012.05.077.
  • Boxall ABA, Rudd MA, Brooks BW, Caldwell DJ, Choi K, Hickmann S, Innes E, Ostapyk K, Staveley JP, Verslycke T, Ankley GT, Beazley KF, Belanger SE, Berninger JP, Carriquiriborde P, Coors A, DeLeo PC, Dyer SD, Gagné F, Giesy JP, Hallstrom L, Karlsson M, Larsson DGJ, Lazorchak JM, Mastrocco F, McLaughlin A, McMaster ME, Meyerhoff RD, Parrott J, Snape JR, Murray-Smith R, Servos MR, Sibley PK, Straub JO, Szabo ND, Topp E, Tetreault GR, Trudeau VL, Van Der Kraak G. (2012) Pharmaceuticals and Personal Care Products in the Environment: What are the Big Questions? Environ Health Perspect. 120:1221 doi:10.1289/ehp.1104477.
  • Svahn S, Göransson U, El-Seedi H, Bohlin L, Larsson DGJ, Olsen B, Chryssanthou E. (2012) Antimicrobial activity of filamentous fungi isolated from highly antibiotic-contaminated river sediment. Infect Ecol Epidemiol. 2:11591 http://dx.doi.org/10.3402/iee.v2i0.11591
  • Cuklev F, Kristiansson E, Gunnarsson L, Cvijovic M, Rutgersson C, Fick J, Grabic R, Björlenius B, Larsson DGJ. (2012) Global hepatic gene expression in fish exposed to sewage effluents: A comparison of different treatment technologies. Sci Total Environ. 427-428: 106 doi: 10.1016/j.scitotenv.2012.04.009.
  • Roos V, Gunnarsson L, Fick J, Larsson DGJ, Rudén C. (2012) Prioritising pharmaceuticals for environmental risk assessment: Towards adequate and feasible first-tier selection. Sci Total Environ. 421-422:102 https://doi.org/10.1016/j.scitotenv.2012.01.039 Recognized by the Society of Toxicology in 2013 to be among the “Top 10 Papers Advancing the Science of Risk Assessment in 2012”.
  • Gunnarsson L, Kristiansson E and Larsson DGJ. (2012)Environmental Comparative Pharmacology: Theory and application. In: Emerging Topics in Ecotoxicology, 1, Vol 4:85 Human Pharmaceuticals in the Environment - Current and Future Perspectives. Eds: B Brooks, D Huggett. Springer Verlag. ISBN 978-1-4614-3419-1. https://doi.org/10.1007/978-1-4614-3473-3_5
  • Janzon A, Kristiansson K, Larsson DGJ. (2012) Environmental microbial communities living under very high antibiotic selection pressure. Invited book chapter in: Antimicrobial Resistance in the Environment. First Edition. Eds. Montforts HMM, Keen PL. Wiley & Blackwell. Pp 483-501.
  • Larsson DGJ. (2012) Utsläpp från läkemedelsindustri påverkar miljön - Antibiotikautsläpp riskerar också vår egen hälsa. Invited review in Swedish. Läkartidningen, 109:750
  • Brandt I, Breitholtz M, la Cour Jansen J, Liljelund K, Larsson DGJ, Rudén C, Tysklind M. (2012) Pharmaceuticals in a Healthy Environment. ISBN: 978-91-978836-2-7. Elanders, Sverige AB Stockholm. 71pp.


  • Cuklev F, Kristiansson K, Fick J, Asker N, Förlin L, Larsson DGJ. (2011) Diclofenac in fish - blood plasma levels similar to human therapeutic levels affect global hepatic gene expression. Environ Toxicol Chem. 30:2126 doi:10.1002/etc.599
  • Lennquist A, Asker N, Kristiansson E, Brenthel A, Björnsson B-T, Kling P, Larsson DGJ, Förlin L. (2011) Physiology and mRNA expression in rainbow trout (Oncorhynchus mykiss) after long-term exposure to the new antifoulant medetomidine. Comp Biochem Physiol C Toxicol Pharmacol. 154:234 https://doi.org/10.1016/j.cbpc.2011.06.002
  • Kristiansson E, Fick J, Janzon A, Grabic R, Rutgersson C, Weijdegård B, Söderström H, Larsson DGJ. (2011) Pyrosequencing of antibiotic-contaminated river sediments reveals high levels of resistance and gene transfer elements. PLoS ONE 6:e17038. doi: 10.1371/journal.pone.0017038. (Highlight in Nature 2011. doi:10.1038/news.2011.46).
  • Holmberg A, Fogel J, Albertsson E, Fick J, Brown JN, Paxéus N, Förlin L, Johnsson J, Larsson DGJ. (2011) Does waterborne citalopram affect the aggressive and sexual behaviour of rainbow trout and guppy? J Hazard Mater. 187:596 doi:10.1016/j.jhazmat.2011.01.055
  • Samuelsson LM, Björlenius B, Förlin L and Larsson DGJ. (2011) Reproducible 1H NMR-based metabolomic responses in fish exposed to different sewage effluents in two separate studies. Environ Sci Technol. 45:1703 doi:10.1021/es104111x
  • Ramaswamy BR, Shanmugam G, Velu G, Rengarajan B, and Larsson DGJ. (2011) GC-MS analysis and ecotoxicological risk assessment of triclosan, carbamazepine and parabens in Indian rivers. J Hazard Mater. 186:1586 doi:10.1016/j.jhazmat.2010.12.037
  • Larsson DGJ and Lööf L. (2011) Läkemedel i miljön. Invited book chapter (In Swedish) in “Läkemedelsboken 2011-2012”, edited and produced by the Swedish Medical Products Agency. Pp 1182-1193. Also available at www.lakemedelsboken.se


  • Kullgren A, Samuelsson L, Larsson DGJ, Björnsson Th, Jönsson Bergman E. (2010). A metabolomics approach to elucidate effects of food deprivation in juvenile rainbow trout (Oncorhynchus mykiss). Am J Physiol Regul Integr Comp Physiol. 299: R1440 doi:10.1152/ajpregu.00281.2010
  • Fick J, Lindberg RH, Tysklind M, Larsson DGJ. (2010). Predicted Critical Environmental Concentrations for 500 Pharmaceuticals. Regul Toxicol Pharmacol. 58:516 doi:10.1016/j.yrtph.2010.08.025
  • Bylander A, Nutu M, Wellander R, Goksör M, Billig H, Larsson DGJ. (2010). Rapid effects of progesterone on ciliary beat frequency in the mouse fallopian tube. Reprod Biol Endocrinol. 8:48 doi:10.1186/1477-7827-8-48
  • Fick J, Lindberg RH, Parkkonen J, Arvidsson B, Larsson DGJ. (2010). Therapeutic levels of levonorgestrel detected in blood plasma of fish: Results from screening rainbow trout exposed to treated sewage effluents. Environ Sci Technol.  44:2661 doi:10.1021/es903440m
  • Albertsson E, Larsson DGJ and Förlin L. (2010). Induction of hepatic carbonyl reductase/20β-hydroxysteroid dehydrogenase mRNA in rainbow trout downstream from sewage treatment works – possible roles of aryl hydrocarbon receptor agonists and oxidative stress. Aquat Toxicol. 97:243 doi:10.1016/j.aquatox.2009.11.007
  • Friberg PA, Larsson DGJ and Billig H. (2010). Transcriptional effects of progesterone receptor antagonist in rat granulosa cells. Mol Cell Endocrinol. 315:121 doi:10.1016/j.mce.2009.09.030
  • Cuklev F, Gunnarsson L, Larsson DGJ. (2010). Genomics as a guide to assess environmental risks of pharmaceuticals. In: Towards sustainable pharmacy in a healthy society. Pp 58-71. ISBN 978-91-978836-0-3.
  • Fick J, Grabic R, Lindberg RH, Larsson DGJ, Tysklind M. (2010). Bioconcentration of pharmaceuticals. In: Towards sustainable pharmacy in a healthy society. Pp 36-45. ISBN 978-91-978836-0-3.
  • Larsson DGJ. (2010). Release of active pharmaceutical ingredients from manufacturing sites – need for new management strategies. Integr Environ Assess Manag. 6:184 doi:10.1002/ieam.20

2009 and before

  • Kristiansson E, Asker N, Förlin F and Larsson DGJ. (2009). Characterization of the Zoarces viviparus liver transcriptome using massively parallel pyrosequencing. BMC Genomics. 10:345 doi:10.1186/1471-2164-10-345
  • Nutu M, Weijdegård B, Thomas P, Thurin-Kjellberg A, Billig H and Larsson DGJ. (2009). Distribution and hormonal regulation of membrane progesterone receptors beta and gamma in ciliated epithelial cells of mouse and human fallopian tubes. Reprod Biol Endocrinol. 7:89 doi:10.1186/1477-7827-7-89
  • Gunnarsson L, Kristiansson E, Rutgersson C, Sturve J, Fick J, Förlin L and Larsson DGJ. (2009). Pharmaceutical industry effluent diluted 1:500 affects global gene expression, CYP1A activity and plasma phosphate in fish. Environ Toxicol Chem. 28:2639 doi:10.1897/09-120.1
  • Gunnarsson L, Adolfsson-Erici M., Björlenius B, Rutgersson C., Förlin L., Larsson D.G.J. (2009). Comparison of six different sewage treatment technologies - reduction of estrogenic substances and effects on gene expression in exposed male fish. Sci Total Environ. 407:5235 doi:10.1016/j.scitotenv.2009.06.018
  • Fick J, Söderström H, Lindberg RH, Chau DNP, Tysklind M, Larsson DGJ. (2009). Contamination of surface, ground, and drinking water from pharmaceutical production. Environ Toxicol Chem. 28:2522 doi:10.1897/09-073.1
  • Larsson DGJ and Fick J. (2009). Transpararency throughout the production chain – a way to reduce pollution from the manufacturing of pharmaceuticals. Regul Toxicol Pharmacol. 53:161 doi:10.1016/j.yrtph.2009.01.008. (Highlight in Nature 2009. 457:640-641).
  • Carlsson G, Örn S and Larsson DGJ. (2009). Effluent from bulk drug production is toxic to aquatic vertebrates. Environ Toxicol Chem. 28:2656 doi:10.1897/08-524.1 (Highlight in Nature 2009. 457:640-641). 
  • Friberg P.A., Larsson D.G., Billig H., (2009). Dominant role of nuclear progesterone receptor in the control of rat periovulatory granulosa cell apoptosis. Biol Reprod. 80, 1160 doi:10.1095/biolreprod.108.073932
  • Rudén C, Brandt I, Breitholtz M, Fick J, la Cour Jansen J, Larsson DGJ, Tysklind M. (2009). Feminized Fish and Vulnerable Vultures – Pharmaceuticals as Environmental Pollutants Require Novel Testing Approches. Pp 148-165. In: A healthy future – Pharmaceuticals in a Sustainable Society. Eds Bengtsson B-E et al. Apoteket AB, Stockholm Sweden. ISBN:2184-01. Available in both English and Swedish.
  • Gunnarsson L, Jauhiainen A, Kristiansson E, Nerman O, Larsson DGJ. (2008). Evolutionary conservation of human drug targets in organisms used for environmental risk assessments. Environ Sci Technol. 42:5807 (Highlight in Environ. Sci. Technol., 2008, 42: 5382–5383, and received the “AstraZeneca Award for the best publication in risk assessment, modeling and theoretical studies” in 2008).

  • Larsson DGJ. (2008). Drug production facilities – an overlooked discharge source for pharmaceuticals to the environment. In Kümmerer K, ed, Pharmaceuticals in the Environment. Sources, Fate, Effects, and Risks. Springer, New York, NY, USA, pp 37-42.
  • Samuelsson L.M and Larsson D.G.J. (2008). Contributions from metabolomics to fish research. Mol Biosyst. 4:974 doi:10.1039/b804196b
  • Larsson DGJ, de Pedro C, Paxeus N. (2007). Effluent from drug manufactures contains extremely high levels of pharmaceuticals. J Hazard Mater. 148:751 doi:10.1016/j.jhazmat.2007.07.008 (Highlight in Nature 2009. 457:640-641).
  • Brown JN, Paxeus N, Forlin L and Larsson DGJ. (2007). Variations in bioconcentration of human pharmaceuticals from sewage effluents into fish blood plasma.Environ Toxicol Pharmacol. 24:267 doi:10.1016/j.etap.2007.06.005
  • Albertsson E., Kling P., Gunnarsson L., Larsson D.G.J. and Förlin L. (2007). Proteomic analyses indicate induction of hepatic carbonyl reductase/20β-hydroxysteroid dehydrogenase B in rainbow trout exposed to sewage effluent. Ecotoxicol Environ Saf. 68:33 doi:10.1016/j.ecoenv.2007.02.003
  • Gunnarsson L., Kristiansson E., Förlin L., Nerman O. and Larsson D.G.J. (2007). Sensitive and robust gene expression changes in fish exposed to estrogen: a microarray approach. BMC Genomics. 8:149 doi:10.1186/1471-2164-8-149
  • Friberg P.A., Larsson D.G.J., Rung E. and Billig H. (2007). Apoptotic effects of a progesterone receptor antagonist on rat granulosa cells are not mediated via reduced protein isoprenylation. Mol Reprod Dev. 74:1317 doi:10.1002/mrd.20711
  • Nutu M., Weijdegård B., Thomas P., Bergh C., Thurin-Kjellberg A., Pang Y., Billig H. and Larsson D.G.J. (2007). Membrane progesterone receptor gamma: tissue distribution and expression in ciliated cells in the fallopian tube. Mol Reprod Dev. 74:843-850 doi:10.1002/mrd.20685.
  • Tyler C.R., Filby A., Iguchi T., Kramer V, Larsson D.G.J., van Aggelen G., van Leeuwen C., Viant M., Tillitt D. (2007). Application of Genomics to Tiered Testing. In: Molecular Biology and Risk Assessment: Evaluation of the Potential Roles of Genomics in Regulatory Ecotoxicology (ed. Ankley G). Society of Environmental Toxicology and Chemistry. CRC Press, New York pp33-62.
  • Carvan MJ, Gallagher E, Goksoyr A, Hahn M, Larsson DGJ and Wirgin I. (2007). Fish models in toxicology: a roundtable discussion. Zebrafish. 4, 9-20.
  • Larsson D.G.J., Fredriksson S., Sandblom E., Paxeus N. and Axelsson M. (2006). Is heart rate in fish a sensitive indicator to evaluate acute effects of β-blockers in surface water? Environ Toxicol Pharmacol. 22:338 doi:10.1016/j.etap.2006.05.002.
  • Samuelsson L., Förlin L., Karlsson G., Adolfsson-Erici M. and Larsson D.G.J. (2006). Using NMR metabolomics to identify responses of an environmental estrogen in blood plasma of fish. Aquat Toxicol. 78:341 doi:10.1016/j.aquatox.2006.04.008.
  • Larsson D.G.J., Adolfsson-Erici M. and Thomas P. (2006). Characterization of putative ligands for a fish gonadal androgen receptor in pulp mill effluent. Environ Toxicol Chem. 25:269
  • Markström E., Friberg P.A., Shao R., Larsson D.G.J., Nielsen E.C., Svensson P.-A., Carlsson B., Carlsson L.M.S and Billig H. (2005). Progesterone receptor antagonists and statins decrease de novo cholesterol synthesis and increase apoptosis in rat and human periovulatory granulosa cells in vitro. Biol Reprod. 72:538 doi:10.1095/biolreprod.104.033878.
  • Larsson J., Norrgren L. and Förlin L. (2005). (English revised version 2006). Hormones and Endocrine disrupting substances in the Environment.Chapter 6, p 84-103. (Invited review) In: Environment and Pharmaceuticals (ed. Wall T.). Apoteksbolaget, Stockholm. Available in English or Swedish from Apoteksbolaget AB, Sweden.
  • Goksøyr A., Arukwe A., Larsson D.G.J., Cajaraville M.P., Hauser L., Nilsen B.M., Lowe D. and Matthiessen P. (2003). Molecular/cellular processes and the impact on reproduction. In: Effects of pollution on fish. Blackwell Science Ltd. pp 179-220. ISBN 0-632-06406-4.
  • Larsson D.G.J., Sperry T. and Thomas P. (2002). Regulation of androgen receptors in Atlantic croaker brains by testosterone and estradiol. Gen Comp Endocrinol. 128:224 https://doi.org/10.1016/S0016-6480(02)00503-8
  • Larsson D.G.J. and Förlin L. (2002). Male-biased sex ratios of fish embryos near a pulp mill: Temporary recovery after a short-term shutdown. Environ Health Perspect. 110:739 
  • Larsson D.G.J., Kinnberg K., Sturve J., Stephensen E., Skön M. and Förlin L. (2002). Studies of masculinization, detoxification and oxidative stress responses in guppies (Poecilia reticulata) exposed to effluent from a pulp mill. Ecotoxicol Environ Saf. 52:13 doi:10.1006/eesa.2001.2139.
  • Larsson D.G.J., Mayer I., Hyllner S.-J. and Förlin L. (2002). Seasonal variations of vitelline envelope proteins, vitellogenin and reproductive steroids in male and female eelpout (Zoarces viviparus). Gen Comp Endocrinol. 125:184 doi:10.1006/gcen.2001.7740.
  • Larsson D.G.J. (2000). PhD-Thesis: Endocrine disruption in fish: sex ratios, secondary sex characters and estrogen-induced proteins. Göteborg University. ISBN 91-628-4104-1.
  • Larsson D.G.J., Hällman H. and Förlin L. (2000). More male fish embryos near a pulp mill. Environ Toxicol Chem. 19:2911 doi:10.1002/etc.5620191210.
  • Livingstone D.R., Mitchelmore C.S., Peters L.D., O’Hara S.C.M., Shaw J., Chesman B., MacEvoy J., Ronisz D., Larsson D.G.J., and Förlin, L. (2000). Development of hepatic CYP1A and blood vitellogenin in eel (Anguilla anguilla) for use as biomarkers in the Thames estuary, UK. Mar Environ Res. 50:367
  • Larsson D.G.J., Adolfsson-Erici M., Parkkonen J., Pettersson, M., Berg H., Olsson P.-E. and Förlin L. (1999). Ethinyloestradiol - an undesired fish contraceptive? Aquatic Toxicology 45:91 https://doi.org/10.1016/S0166-445X(98)00112-X
  • Ronisz D., Larsson D.G.J. and Förlin, L. (1999). Seasonal variations in the activities of selected hepatic biotransformation and antioxidant enzymes in eelpout (Zoarces viviparus). Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 124:271
  • Norrgren, L., Blom, A., Andersson, P.L., Börjesson, H., Larsson, D.G.J. and Olsson, P.-E. (1999). Effects of potential xenoestrogens (DEHP, nonylphenol and PCB) on sexual differentiation in juvenile Atlantic salmon (Salmo salar). Aquatic Ecosystem Health and Management 2, 311-317.
  • Larsson D.G.J., Mylonas C.C., Zohar Y. and Crim L.W. (1997). Gonadotropin releasing hormone-analogue (GnRH-A) induces multiple ovulations of high quality eggs in a cold-water batch-spawning teleost, the yellowtail flounder (Pleuronectes ferrugineus). Canadian Journal of Fisheries an Aquatic Sciences 54 (9), 1957-196.
  • Hyllner S.J., Fernandez-Palacios Barber H., Larsson D.G.J. and Haux C. (1995). Amino acid composition and endocrine control of vitelline envelope proteins in European sea bass (Dicentrarchus labrax) and gilthead sea bream (Sparus aurata). Mol Reprod Dev. 41:339 doi:10.1002/mrd.1080410309.
  • Larsson D.G.J., Hyllner S.J. and Haux C. (1994).Induction of vitelline envelope proteins by estradiol-17 beta in 10 teleost species. Gen Comp Endocrinol. 96:445 doi:10.1006/gcen.1994.1201.


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