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miRNA regulation in development and disease

microRNA in normal cells and stem cells

Aishe Sarshad

Contact information | List of publications

Argonaute (AGO) proteins, loaded with small interfering RNAs (siRNAs) or microRNAs (miRNAs), are the core components of RNA induced silencing complex (RISC). The small RNAs guide the AGO ribonucleoprotein to complementary target RNAs resulting in gene silencing.

microRNAs (miRNAs), 21-23 nucleotide long non-coding RNA molecules, are expressed in a cell type-specific manner and can accumulate to tens of thousands of copies per cell. It is estimated that up to 60% of human genes are under miRNA regulation.

miRNA silencing pathways play important roles in a number of biological processes, including embryonic stem cell differentiation and tissue development. Deregulation of this pathway is associated with various diseases; therefore, it is essential to fully understand the molecular mechanisms of miRNA regulation.

We recently discovered that miRNAs, Argonaute proteins, and key factors of the RISC silencing complex are expressed in the nucleus, specifically in mammalian embryonic stem cells. Our current work aims at decoding the regulatory pathways of nuclear RISC. Specifically, we want to understand why stem cells need nuclear miRNA-Argonaute complexes for gene regulation and how these play a role during stem cell differentiation and reprograming. We further aim to understand if nuclear RNA interference by RISC can be used in cancers as a way of targeting nuclear factors important in cancer development.

Group members

Aishe Sarshad, PhD, junior group leader
Wail Chrifi, Research Assistant
 

Sidansvarig: Dan Baeckström|Sidan uppdaterades: 2019-04-01
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Denna text är utskriven från följande webbsida:
http://biomedicine.gu.se/ominst/avd/medkem/forskare/aishe-sarshad/?tipFriend=true&tipUrl=http%3A%2F%2Fbiomedicine.gu.se%2Fominst%2Favd%2Fmedkem%2Fforskare%2Faishe-sarshad%2F
Utskriftsdatum: 2019-08-21