Investigating the ALK receptor tyrosine kinase in development and disease

The Palmer research group employs a range of model systems, from the fruit fly to mouse tumour models as well as human cell lines and patient tumour samples to understand the role of the ALK receptor tyrosine kinase in development and disease. This combined approach is particularly relevant in neuroblastoma, a paediatric cancer often arising in the first years of life. The team employs mouse and Drosophila models of neuroblastoma as well as investigation of ALK driven processes in preclinical and translational settings, often working closely with international collaborators. The Palmer lab aims to perform high-quality basic research providing insight into understanding ALK function in normal and pathological situations and dedicates significant effort to translational research with aim of improving therapeutic options for neuroblastoma.