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Probing function of transmembrane mucins in intestinal protection

Left: Bacteria (red) adhere to the apical surface of intestinal epithelial cells (green). Right: Microvilli (white arrows) on apical surfaces of intestinal epithelial cells are covered with transmembrane mucins (black arrow).

 

Thaher Pelaseyed

Contact information  |  List of publications  |  External website

The emerging importance of host-microbe interactions for our health gives urgency to understanding how host intestinal epithelial cells sense gut microbes in health and disease. Long, extended transmembrane mucins cover the entire apical brush border of epithelial cells of the small and large intestines. Our long-term goal is to elucidate the fundamental function of intestinal transmembrane mucins and to understand how transmembrane mucins assist host intestinal epithelial cells in surveillance of the gut microbiota. The central hypothesis of our research is that a specific consortium of microbiota promotes MUC17 expression and deployment to apical surfaces, where MUC17 functions as a host receptor for specific bacterial products. Recognition of bacterial products by MUC17 triggers the innate immune system in order to promote protection against the microbiota. We believe that our research will advance our knowledge of an overlooked group of epithelial surface glycoproteins and our findings will have significant impact on our understanding of host-microbiota crosstalk in the intestine.

 

Group members

Thaher Pelaseyed, PhD, principal investigator, Assistant professor (forskarassistent)
Elena Layunta, PhD, Postdoc
Sofia Jäverfelt, MSc, PhD student
Gustaf Hellsén, Undergraduate student 

Sidansvarig: Dan Baeckström|Sidan uppdaterades: 2018-08-13
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