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Research group on Tumor Biology

 Chromosome rearrangements that lead to formation of fusion genes have been identified in many types of leukemia and solid tumors. Close to 700 different fusion oncogenes are reported in human neoplasias. A long line of observations indicates that fusion oncogenes are highly potent and important factors in tumor development. Many fusion genes were found to transform cells in culture and capable to induce tumors in transgenic mice.

Most fusion genes are associated with only one type of tumors. This tumor type specificity suggests that their products interact with distinct differentiation controlling gene programs.

The aim of our research is to investigate the activities of the FET family of fusion oncogenes to increase our understanding of how their activities lead to tumor formation and how they interact with growth and differentiation controlling gene programs.

Our main experimental activities focus on the myxoid liposarcoma/round cell sarcoma specific FUS-CHOP and the Ewing sarcoma EWS-FLI1 fusion oncogenes and the interaction of their protein products with the transcription factors controlling cell growth and differentiationt. We are also investigating other tumor types that carry fusion genes composed of the same or related partner genes.

Many observations suggest that tumor development is initiated in stem or precursor cells. As a part of our research on sarcomas we are characterizing mesenchymal stem/precursor cells and mapping their distribution in normal tissues. The effects of fusion genes are tested by transfection experiments into various types of cultured mesenchymal precursor cells.

Sidansvarig: Dan Baeckström|Sidan uppdaterades: 2011-04-19

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