Edward Trybala

Identification of epidermal growth factor receptor-tyrosine kinase inhibitor targeting the VP1 pocket of human

Masum Miah, Andrew M. Davis, Charles Hannoun, Joanna Said, Martina Fitzek, Marian Preston, Dave Smith, Colores Uwamariya, Ambjörn Kärmander, Thomas Lundback, Tomas Bergström, Edward Trybala
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY - 2024

Crotofolane Diterpenoids and Other Constituents Isolated from Croton

kilwae.

Emanuel T Mahambo, Colores Uwamariya, Masum Miah, Leandro da Costa Clementino, Luis Carlos Salazar Alvarez, Gabriela Paula Di Santo Metzler, Edward Trybala, Joanna Said, Lianne H E Wieske, Jas S Ward, Kari Rissanen, Joan J E Munissi, Fabio T M Costa, Per Sunnerhagen, Tomas Bergström, Stephen S Nyandoro, Mate Erdelyi
Journal of Natural Products - 2023

Structure and Role of O-Linked Glycans in Viral Envelope

Proteins

Sigvard Olofsson, M. Bally, Edward Trybala, Tomas Bergström
Annual Review of Virology - 2023

Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike-ACE2

Interaction

S. E. Guimond, C. J. Mycroft-West, N. S. Gandhi, J. A. Tree, T. T. Le, C. M. Spalluto, M. V. Humbert, K. R. Buttigieg, N. Coombes, M. J. Elmore, M. Wand, Kristina Nyström, Joanna Said, Y. X. Setoh, A. A. Amarilla, N. Modhiran, J. D. J. Sng, M. Chhabra, P. R. Young, D. J. Rawle, M. A. Lima, E. A. Yates, R. Karlsson, R. L. Miller, Y. H. Chen, I. Bagdonaite, Z. Yang, J. Stewart, D. Nguyen, S. Laidlaw, E. Hammond, K. Dredge, T. M. A. Wilkinson, D. Watterson, A. A. Khromykh, A. Suhrbier, M. W. Carroll, Edward Trybala, Tomas Bergström, V. Ferro, M. A. Skidmore, J. E. Turnbull
ACS Central Science - 2022

Modified ent-Abietane Diterpenoids from the Leaves of Suregada

zanzibariensis

T. M. Kalenga, J. T. Mollel, Joanna Said, A. Orthaber, J. S. Ward, Y. Atilaw, D. Umereweneza, M. M. Ndoile, J. J. E. Munissi, K. Rissanen, Edward Trybala, Tomas Bergström, S. S. Nyandoro, M. Erdelyi
Journal of Natural Products - 2022

Cellular Chondroitin Sulfate and the Mucin-like Domain of Viral Glycoprotein C Promote Diffusion of Herpes Simplex Virus 1 While Heparan Sulfate Restricts

Mobility

Y. Abidine, L. F. Liu, O. Wallen, Edward Trybala, Sigvard Olofsson, Tomas Bergström, M. Bally
Viruses - 2022

Anti-respiratory syncytial virus and anti-herpes simplex virus activity of six Tanzanian medicinal plants with extended studies of Erythrina abyssinica stem

bark

Jackson T. Mollel, Joanna Said, R. J. Masalu, Charles Hannoun, M. V. N. Mbunde, R. S. O. Nondo, Tomas Bergström, Edward Trybala
Journal of Ethnopharmacology - 2022

Antiviral iridoid glycosides from Clerodendrum

myricoides

D. Umereweneza, Jackson T. Molel, Joanna Said, Y. Atilaw, T. Muhizi, Edward Trybala, Tomas Bergström, A. Gogoll, M. Erdelyi
Fitoterapia - 2021

Herpes Simplex Virus Type 2 Mucin-Like Glycoprotein mgG Promotes Virus Release from the Surface of Infected

Cells

Edward Trybala, N. Peerboom, Beata Adamiak, Malgorzata Krzyzowska, Jan-Åke Liljeqvist, M. Bally, Tomas Bergström
Viruses - 2021

Herpes Simplex Virus 1 and 2 Infections during Differentiation of Human Cortical

Neurons

Petra Bergström, Edward Trybala, Charlotta Eriksson, Maria Johansson, Tugce Munise Satir, Sibylle Widehn, Stefanie Fruhwürth, W. Michno, Faisal Hayat Nazir, Jörg Hanrieder, Sören R Paludan, Lotta Agholme, Henrik Zetterberg, Tomas Bergström
Viruses-Basel - 2021

Surveillance of wastewater revealed peaks of SARS-CoV-2 preceding those of hospitalized patients with

COVID-19.

Fredy Saguti, Ellen Magnil, Lucica Enache, Marianela Patzi Churqui, Anette Johansson, Douglas Lumley, Fredrik Davidsson, Leif Dotevall, Ann Mattsson, Edward Trybala, Martin Lagging, Magnus Lindh, Magnus Gisslén, Thomas Brezicka, Kristina Nyström, Helene Norder
Water research - 2021

Cell Membrane Derived Platform To Study Virus Binding Kinetics and Diffusion with Single Particle

Sensitivity

N. Peerboom, E. Schmidt, Edward Trybala, S. Block, Thomas Bergström, H. P. Pace, M. Bally
Acs Infectious Diseases - 2018

Binding Kinetics and Lateral Mobility of HSV-1 on End-Grafted Sulfated

Glycosaminoglycans

N. Peerboom, S. Block, N. Altgarde, O. Wahlsten, S. Moller, M. Schnabelrauch, Edward Trybala, Tomas Bergström, M. Bally
Biophysical Journal - 2017

The Cholestanol-Conjugated Sulfated Oligosaccharide PG545 Disrupts the Lipid Envelope of Herpes Simplex Virus

Particles

Joanna Said, Edward Trybala, Staffan Görander, Maria Ekblad, Jan-Åke Liljeqvist, Eva Jennische, Stefan Lange, Tomas Bergström
Antimicrobial agents and chemotherapy - 2016

Mucin-like region of herpes simplex virus type 1 attachment protein gC modulates the virus-glycosaminoglycan

interaction.

Noomi Altgärde, Charlotta Eriksson, Nadia Peerboom, Tuan Phan-Xuan, Stephanie Möller, Matthias Schnabelrauch, Sofia Svedhem, Edward Trybala, Tomas Bergström, Marta Bally
Journal of Biological Chemistry - 2015

The anterior commissure is a pathway for contralateral spread of herpes simplex virus type 1 after olfactory tract

infection

Eva Jennische, Charlotta Eriksson, Stefan Lange, Edward Trybala, Tomas Bergström
Journal of Neurovirology - 2015

Targeting Membrane-Bound Viral RNA Synthesis Reveals Potent Inhibition of Diverse Coronaviruses Including the Middle East Respiratory Syndrome

Virus

Anna Lundin, R. Dijkman, Tomas Bergström, Nina Kann, Beata Adamiak, Charles Hannoun, E. Kindler, H. R. Jonsdottir, D. Muth, J. Kint, M. Forlenza, M. A. Muller, C. Drosten, V. Thiel, Edward Trybala
Plos Pathogens - 2014

HIV-1 variants with reduced sensitivity to sulfated oligosaccharide muparfostat contain mutations in the envelope glycoproteins gp120 and

gp41

Joanna Said, Elin Andersson, Edward Trybala, Tomas Bergström
Journal of Antivirals and Antiretrovirals - 2013

Screening and evaluation of anti-respiratory syncytial virus compounds in cultured

cells.

Anna Lundin, Tomas Bergström, Edward Trybala
Antiviral Methods and Protocols. Ed. Edwin Yunhao Gong. (Methods in molecular biology, 1030) - 2013

Involvement of viral glycoprotein gC-1 in expression of the selectin ligand sialyl-Lewis X induced after infection with herpes simplex virus type

1.

Rickard Nordén, Kristina Nyström, Beata Adamiak, Adnan Halim, Jonas Nilsson, Göran Larson, Edward Trybala, Sigvard Olofsson
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 2013

Potent anti-respiratory syncytial virus activity of a cholestanol-sulfated tetrasaccharide

conjugate.

Anna Lundin, Tomas Bergström, Carla Regina Andrighetti-Fröhner, Loubna Bendrioua, Vito Ferro, Edward Trybala
Antiviral research - 2012

Human antibodies to herpes simplex virus type 1 glycoprotein C are neutralizing and target the heparan sulfate-binding

domain

Beata Adamiak, Edward Trybala, K. Mardberg, M. Johansson, Jan-Åke Liljeqvist, Sigvard Olofsson, A. Grabowska, K. Bienkowska-Szewczyk, B. Szewczyk, Tomas Bergström
Virology - 2010

Two novel fusion inhibitors of human respiratory syncytial

virus

Anna Lundin, Tomas Bergström, Loubna Bendrioua, Nina Kann, Beata Adamiak, Edward Trybala
Antiviral Research - 2010

Lipophile-conjugated sulfated oligosaccharides as novel microbicides against

HIV-1.

Joanna Said, Edward Trybala, Elin Andersson, Ken Johnstone, Ligong Liu, Norbert Wimmer, Vito Ferro, Tomas Bergström
Antiviral research - 2010

A highly lipophilic sulfated tetrasaccharide glycoside related to muparfostat (PI-88) exhibits virucidal activity against herpes simplex

virus.

Maria Ekblad, Beata Adamiak, Tomas Bergström, Ken D Johnstone, Tomislav Karoli, Ligong Liu, Vito Ferro, Edward Trybala
Antiviral research - 2010

Evaluation of anti-HSV-2 activity of gallic acid and pentyl

gallate.

Jadel Müller Kratz, Carla Regina Andrighetti-Fröhner, Paulo César Leal, Ricardo José Nunes, Rosendo Augusto Yunes, Edward Trybala, Tomas Bergström, Célia Regina Barardi Monte, Cláudia Maria Oliveira Simões
Biological & pharmaceutical bulletin - 2008

Herpes simplex virus type 2 glycoprotein g is targeted by the sulfated oligo- and polysaccharide inhibitors of virus attachment to

cells

Beata Adamiak, Maria Ekblad, Tomas Bergström, Vito Ferro, Edward Trybala
Journal of Virology - 2007

Molecular basis for resistance of herpes simplex virus type 1 mutants to the sulfated oligosaccharide inhibitor

PI-88.

Maria Ekblad, Beata Adamiak, Kicki Bergefall, Hannah Nenonen, Anette Roth, Tomas Bergström, Vito Ferro, Edward Trybala
Virology - 2007

Chondroitin 4-O-sulfotransferase-1 regulates E disaccharide expression of chondroitin sulfate required for herpes simplex virus

infectivity.

Toru Uyama, Miho Ishida, Tomomi Izumikawa, Edward Trybala, Frank Tufaro, Tomas Bergström, Kazuyuki Sugahara, Hiroshi Kitagawa
The Journal of biological chemistry - 2006

Anti-herpes simplex virus activities of two novel disulphated

cyclitols.

Maria Ekblad, Tomas Bergström, Martin G Banwell, Muriel Bonnet, Jens Renner, Vito Ferro, Edward Trybala
Antiviral chemistry & chemotherapy - 2006

Synthesis, biological activity, and preliminary pharmacokinetic evaluation of analogues of a phosphosulfomannan angiogenesis inhibitor

(PI-88).

Tomislav Karoli, Ligong Liu, Jon K Fairweather, Edward Hammond, Cai Ping Li, Siska Cochran, Kicki Bergefall, Edward Trybala, Russell S Addison, Vito Ferro
Journal of medicinal chemistry - 2005

Chondroitin sulfate characterized by the E-disaccharide unit is a potent inhibitor of herpes simplex virus infectivity and provides the virus binding sites on gro2C

cells.

Kicki Bergefall, Edward Trybala, Maria Johansson, Toru Uyama, Satomi Naito, Shuhei Yamada, Hiroshi Kitagawa, Kazuyuki Sugahara, Tomas Bergström
The Journal of biological chemistry - 2005

The Synthesis and Biological Evaluation of Two Analogues of the C-Riboside

Showdomycin

Jens Renner, Irma Kruszelnicki, Beata Adamiak, Anthony C Willis, Edward Hammond, Stephen Su, Christopher Burns, Edward Trybala, Vito Ferro, Martin G Banwell
Australian Journal of Chemistry - 2005

Structural and functional features of the polycationic peptide required for inhibition of herpes simplex virus invasion of

cells.

Edward Trybala, Sigvard Olofsson, Kristina Mårdberg, Bo Svennerholm, Kimiko Umemoto, Joseph C Glorioso, Tomas Bergström
Antiviral research - 2004

Inhibition of herpes simplex virus infection by lactoferrin is dependent on interference with the virus binding to

glycosaminoglycans.

Magda Marchetti, Edward Trybala, Fabiana Superti, Maria Johansson, Tomas Bergström
Virology - 2004

Basic amino acids as modulators of an O-linked glycosylation signal of the herpes simplex virus type 1 glycoprotein gC: functional roles in viral

infectivity.

Kristina Mårdberg, Kristina Nyström, Mads Tarp Agervig, Edward Trybala, Henrik Clausen, Tomas Bergström, Sigvard Olofsson
Glycobiology - 2004

The low molecular weight heparan sulfate-mimetic, PI-88, inhibits cell-to-cell spread of herpes simplex

virus.

Kicki Nyberg, Maria Ekblad, Tomas Bergström, Craig Freeman, Christopher R Parish, Vito Ferro, Edward Trybala
Antiviral research - 2004

Edward Trybala

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