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Martin Lagging

Professor/överläkare

Martin Lagging
Professor/överläkare
Specialistläkare i infektionssjukdomar och virologi
Akademisk grad: Docent,
martin.lagging@medfak.gu.se
0 31-342 4731
0705-683759

Rumsnummer: Våning 5
Postadress: Guldhedsgatan 10A, 41346 Göteborg
Besöksadress: Guldhedsgatan 10A , 41346 Göteborg
Arbetsuppgifter: Professor, universitetssjukhusöverläkare


Avd för infektionssjukdomar vid Institutionen för biomedicin (Mer information)
Box 480
405 30 Göteborg
0313421000
Besöksadress: Guldhedsgatan 10 A-B , 413 46 Göteborg

Om Martin Lagging

Role of Genetic Variations of Innate Immunity in Microbial Infections

Research Focus:

Our group has focused on translational studies and interventional/therapeutic trials on hepatitis C virus (HCV) with the goal of improving outcome as well as minimizing the risk of adverse events. In particular, we evaluated the impact of host factors such as interferon-gamma inducible protein 10 (IP-10; also known as CXCL10) as well human genetic variants, e.g. in the gene coding for interferon-lambda 4 (IFNL4; previously known as IL28B), on liver histopathology, response to therapy, and outcome for HCV treatment.

More recently, we have evaluated the impact of genetic variations in the inosine triphosphate pyrophosphatase (ITPase) gene on HCV infection, and reported a novel ribavirin-like reduced risk of relapse among patients having reduced ITPase activity. The evolutionary conserved ITPase is a cytosolic enzyme that recycles purines by the pyrophosphohydrolysis of ITP to inosine monophosphate (IMP), and thus protects against accumulation of non-canonical nucleotides such as ITP and xanthosine triphosphate (XTP) as well as their deoxy forms (dITP and dXTP), which otherwise incorrectly may be incorporated into RNA and DNA producing genetic instability, anomalous proteins, and altered ATP-dependent signaling.

In the near future, we plan to expand our evaluation of ITPase to include other microbial infections, as we hypothesize that inhibition of ITPase may point to novel antiviral and antibacterial strategies.

Senaste publikationer

Hepatitis E virus genotype 3 is associated with gallstone-related disease
Miriam Karlsson, Helene Norder, Maria Bergström, Per-Ola Park, Marie Karlsson et al.
Scandinavian Journal of Gastroenterology, Artikel i vetenskaplig tidskrift 2019
Artikel i vetenskaplig tidskrift

Lower risk of multiple sclerosis in patients with chronic hepatitis C: a nationwide population-based registry study
J. Soderholm, Aylin Yilmaz, A. Svenningsson, K. Busch, Rune Wejstål et al.
Journal of Neurology, Artikel i vetenskaplig tidskrift 2019
Artikel i vetenskaplig tidskrift

Sofosbuvir/velpatasvir for the treatment of HCV: excellent results from a phase-3, open-label study in Russia and Sweden
V. Isakov, V. Chulanov, D. Abdurakhmanov, E. Burnevich, E. Nurmukhametova et al.
Infectious Diseases, Artikel i vetenskaplig tidskrift 2019
Artikel i vetenskaplig tidskrift

Treatment of hepatitis C virus infection for adults and children: updated Swedish consensus guidelines 2017
Martin Lagging, Rune Wejstål, A. S. Duberg, S. Aleman, O. Weiland et al.
Infectious Diseases, Artikel i vetenskaplig tidskrift 2018
Artikel i vetenskaplig tidskrift

Reduced ITPase activity and favorable IL28B genetic variant protect against ribavirin-induced anemia in interferon-free regimens
A. Vasanthakumar, J. W. Davis, M. Abunimeh, J. Soderholm, J. H. Zha et al.
Plos One, Artikel i vetenskaplig tidskrift 2018
Artikel i vetenskaplig tidskrift

PRO-C3: a new and more precise collagen marker for liver fibrosis in patients with chronic hepatitis C
J. F. Hansen, M. J. Nielsen, Kristina Nyström, D. J. Leeming, Martin Lagging et al.
Scandinavian Journal of Gastroenterology, Artikel i vetenskaplig tidskrift 2018
Artikel i vetenskaplig tidskrift

Cartilage oligomeric matrix protein associates with hepatic inflammation and fibrosis in hepatitis C virus infection
Kristofer Andréasson, Jesper Waldenström, Johan Westin, Hans Norrgren, Göran Jönsson et al.
Journal of Hepatology, Artikel i vetenskaplig tidskrift 2017
Artikel i vetenskaplig tidskrift

Visar 1 - 10 av 81

2019

Hepatitis E virus genotype 3 is associated with gallstone-related disease
Miriam Karlsson, Helene Norder, Maria Bergström, Per-Ola Park, Marie Karlsson et al.
Scandinavian Journal of Gastroenterology, Artikel i vetenskaplig tidskrift 2019
Artikel i vetenskaplig tidskrift

Lower risk of multiple sclerosis in patients with chronic hepatitis C: a nationwide population-based registry study
J. Soderholm, Aylin Yilmaz, A. Svenningsson, K. Busch, Rune Wejstål et al.
Journal of Neurology, Artikel i vetenskaplig tidskrift 2019
Artikel i vetenskaplig tidskrift

Sofosbuvir/velpatasvir for the treatment of HCV: excellent results from a phase-3, open-label study in Russia and Sweden
V. Isakov, V. Chulanov, D. Abdurakhmanov, E. Burnevich, E. Nurmukhametova et al.
Infectious Diseases, Artikel i vetenskaplig tidskrift 2019
Artikel i vetenskaplig tidskrift

2018

Treatment of hepatitis C virus infection for adults and children: updated Swedish consensus guidelines 2017
Martin Lagging, Rune Wejstål, A. S. Duberg, S. Aleman, O. Weiland et al.
Infectious Diseases, Artikel i vetenskaplig tidskrift 2018
Artikel i vetenskaplig tidskrift

Reduced ITPase activity and favorable IL28B genetic variant protect against ribavirin-induced anemia in interferon-free regimens
A. Vasanthakumar, J. W. Davis, M. Abunimeh, J. Soderholm, J. H. Zha et al.
Plos One, Artikel i vetenskaplig tidskrift 2018
Artikel i vetenskaplig tidskrift

PRO-C3: a new and more precise collagen marker for liver fibrosis in patients with chronic hepatitis C
J. F. Hansen, M. J. Nielsen, Kristina Nyström, D. J. Leeming, Martin Lagging et al.
Scandinavian Journal of Gastroenterology, Artikel i vetenskaplig tidskrift 2018
Artikel i vetenskaplig tidskrift

2017

Cartilage oligomeric matrix protein associates with hepatic inflammation and fibrosis in hepatitis C virus infection
Kristofer Andréasson, Jesper Waldenström, Johan Westin, Hans Norrgren, Göran Jönsson et al.
Journal of Hepatology, Artikel i vetenskaplig tidskrift 2017
Artikel i vetenskaplig tidskrift

Visar 1 - 10 av 81

Sidansvarig: Evelyn Vilkman|Sidan uppdaterades: 2017-08-28
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