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Thaher Pelaseyed


Thaher Pelaseyed
031-786 3154

Postadress: Box 440, 40530 Göteborg
Besöksadress: Medicinaregatan 9 a , 41390 Göteborg
Arbetsuppgifter: We aim to uncover how membrane mucins promote protection in intestinal epithelial cells

Avd för medicinsk kemi och cellbiologi vid Institutionen för biomedicin (Mer information)
Box 440
405 30 Göteborg
Fax: 0 31416108
Besöksadress: Medicinaregatan 9 A-B , 413 90 Göteborg

Om Thaher Pelaseyed

Bacteria in our intestine exceed 10 trillions. In healthy individuals, an impermeable layer of secreted mucins separates bacteria from host intestinal cells.

In diseases such as Inflammatory bowel disease, bacteria breach the mucus barrier and reach epithelial cells covered with bottlebrush-like glycoproteins called transmembrane mucins. Despite the fact that transmembrane mucins extend up to 1 μm into the intestinal lumen and are ideal docking sites for penetrating bacteria, their biological function is unknown.

Our goal is to determine how transmembrane mucins sense bacteria and induce intestinal cell protection against bacterial infections.

Current funding and support:
- Swedish Society for Medical Research, Start grant #S17-0005 (2018-2023)
- NIH/NIAID/MIST Scholar Award in Mucosal Immunity (2018-2020)
- Sahlgrenska Academy PhD Training Grant #U2018/162 (2019-2023)
- The Wenner-Gren Foundations, Starting grant #FT2017-0002 (2017-2019)
- The Wenner-Gren Foundations, International Postdoc Training grant, #UPD2018-0065 (2018-2020)
- Åke Wiberg's Foundation, Research grant, #M17-0062 (2018-2019)
- The Jeansson Foundations, Startup grant #JS2017-0003 (2018-2019)

Read more about our research and open positions here.

Senaste publikationer

Regulation of actin-based apical structures on epithelial cells
Thaher Pelaseyed
Journal of Cell Science, Artikel i vetenskaplig tidskrift 2018
Artikel i vetenskaplig tidskrift

Ezrin activation by LOK phosphorylation involves a PIP2-dependent wedge mechanism.
Thaher Pelaseyed, Raghuvir Viswanatha, Cécile Sauvanet, Joshua J Filter, Michael L Goldberg et al.
eLife, Artikel i vetenskaplig tidskrift 2017
Artikel i vetenskaplig tidskrift

Murine Butyrophilin-Like 1 and BtnI6 Form Heteromeric Complexes in Small Intestinal Epithelial Cells and Promote Proliferation of Local T Lymphocytes
Cristina Lebrero-Fernandez, Joakim H. Bergström, Thaher Pelaseyed, Anna Bas-Forsberg
Frontiers in Immunology, Artikel i vetenskaplig tidskrift 2016
Artikel i vetenskaplig tidskrift

Structure, regulation, and functional diversity of microvilli on the apical domain of epithelial cells.
Cécile Sauvanet, Jessica Wayt, Thaher Pelaseyed, Anthony Bretscher
Annual review of cell and developmental biology, Forskningsöversiktsartikel 2015

Carbachol-induced MUC17 endocytosis is concomitant with NHE3 internalization and CFTR membrane recruitment in enterocytes.
Thaher Pelaseyed, Jenny K Gustafsson, Ida J Gustafsson, Anna Ermund, Gunnar C. Hansson
American journal of physiology. Cell physiology, Artikel i vetenskaplig tidskrift 2013
Artikel i vetenskaplig tidskrift

Unfolding dynamics of the mucin SEA domain probed by force spectroscopy suggest that it acts as a cell-protective device.
Thaher Pelaseyed, Michael Zäch, Asa C Petersson, Frida Svensson, Denny G A Johansson et al.
The FEBS journal, Artikel i vetenskaplig tidskrift 2013
Artikel i vetenskaplig tidskrift

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Sidansvarig: Evelyn Vilkman|Sidan uppdaterades: 2017-08-28

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